Leukocoria Caused by Intraocular Heterotopic Brain Tissue

Patel, Sarit

doi:10.1001/archopht.122.3.390

Cited by 8 publications

(7 citation statements)

References 17 publications

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“…In all species, brain tissue within the orbit without a bony defect in the orbit indicating a meningocoele or an encephalocoele is very rare 5 . In humans, many of the cases reported in infants are associated with other morphologic abnormalities in the globe, orbit or brain 5,6,9,10 . Ectopic brain tissue within the orbit has also been reported in adults, often diagnosed as an incidental finding 7 .…”

Section: Discussionmentioning

confidence: 99%

“… 10 have reported a large intraorbital mass appearing to arise from both retina and RPE in a 5‐day‐old baby girl. This lesion showed a great degree of architectural sophistication with brain‐like tissue positive for synaptophysin containing large crystal violet positive neurons, GFAP‐positive astrocytes, and oligodendrocytes within neuropil exhibiting rare focal calcification 10 . An 8‐day‐old male infant has also been reported to have a brain choristoma arising from the inner layers of the retina 11 .…”

Section: Discussionmentioning

confidence: 99%

“…5 In humans, many of the cases reported in infants are associated with other morphologic abnormalities in the globe, orbit or brain. 5,6,9,10 Ectopic brain tissue within the orbit has also been reported in adults, often diagnosed as an incidental finding. 7 Scheiner et al 5 have reported an orbital mass taken from a 9-month-old male infant that consisted of dysplastic brain tissue intermixed with primitive retinal elements, including RPE.…”

Section: Discussionmentioning

confidence: 99%

“…9 The occurrence of ectopic brain tissue within the retina is even more rare. Patel et al 10 have reported a large intraorbital mass appearing to arise from both retina and RPE in a 5-day-old baby girl. This lesion showed a great degree of architectural sophistication with brain-like tissue positive for synaptophysin containing large crystal violet positive neurons, GFAP-positive astrocytes, and oligodendrocytes within neuropil exhibiting rare focal calcification.…”

Section: Discussionmentioning

confidence: 99%

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Ectopic brain tissue in the retina of a beagle dog: a case report and literature review

Allavena

Phillips

Andrews

2011

Veterinary Ophthalmology

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Isolated ectopic brain tissue within the orbit is an extremely rare finding and has never been reported in dogs or other domestic species. In this case, a focal choristoma of ectopic grey matter-like tissue was present within the retina of a mature female beagle dog, and consisted of neurons and astrocytes as demonstrated respectively by microtubule-associated protein 2 and glial fibrillary acidic protein immunohistochemistry. The lesion was located within the optic fundus adjacent to the optic disk and surrounded by dysplastic retina. The case is presented with a review of literature on this rare entity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Ectopic brain tissue in the retina of a beagle dog: a case report and literature review

Allavena

Phillips

Andrews

2011

Veterinary Ophthalmology

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“…Other reports described an 8-dayold boy (Paysse, Coats, & Chevez-Barrios, 2003) and a 5-day-old girl (Patel et al, 2004) who had heterotopic brain tissues in their retinas.…”

Section: Choristomas In the Retinamentioning

confidence: 97%

Intraocular Choristoma

Kim

Henderson

2005

Seminars in Ophthalmology

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Choristomas have been reported in the orbit, cornea, conjunctiva, uvea, retina, and optic nerve. Many reports have described the choristoma mainly in the epibulbar area, but little is known of the choristoma that occurs intraocularly. We reviewed the literature and summarized the reports that described the choristoma inside the eyes. Iris, ciliary body, choroid, and optic nerve head are the commonly affected tissues. In the anterior uveal tissue, an ectopic lacrimal gland is common and appears as a pinkish, nodular, fleshy mass. Its clinical course largely depends on the enlargement of the accompanying cyst. Osseous choristoma is mainly found in the choroid in young female patients. Although it is regarded as a benign tumor, it grows progressively and can decrease visual function. Treatment consists of close observation and possibly surgical intervention. Fortunately, most of the intraocular choristomas do not need aggressive treatment.

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Presumed Solitary Circumscribed Retinal Astrocytic Proliferation

Shields¹

2011

Arch Ophthalmol

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Objective: To report the clinical features and differential diagnosis of an unusual entity termed presumed solitary circumscribed retinal astrocytic proliferation (PSCRAP). Methods: Retrospective review of medical records. Results: All patients with PSCRAP were asymptomatic, and the lesion was found during routine examination. There were 5 men and 2 women with a median age of 53 years. No patient had a history or clinical findings of tuberous sclerosis complex. Each PSCRAP lesion was circumscribed, abruptly elevated, and opaque white to yellow and mostly obscured the underlying retinal vessels. The lesions had no associated subretinal fluid, hemorrhage, calcification, or retinal traction. Fluorescein angiography disclosed mild hyperfluorescence in the venous phase and moderate late staining of the lesions. Autofluorescence showed mild hyperautofluorescence of the lesions. Ultrasonography revealed no calcification. Optical coherence tomography showed an abruptly elevated retinal mass with optical shadowing posterior to the lesion. Six lesions were stable after a median follow-up of 6 years, and 1 lesion gradually disappeared. The pathogenesis and pathologic features of PSCRAP are unknown. Conclusion: Presumed solitary circumscribed retinal astrocytic proliferation appears to be a unique retinal lesion of adulthood that resembles astrocytic hamartoma or retinoblastoma but displays distinctive ophthalmoscopic features.

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Leukocoria Caused by Intraocular Heterotopic Brain Tissue

Cited by 8 publications

References 17 publications

Ectopic brain tissue in the retina of a beagle dog: a case report and literature review

Ectopic brain tissue in the retina of a beagle dog: a case report and literature review

Intraocular Choristoma

Presumed Solitary Circumscribed Retinal Astrocytic Proliferation

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