Leukocyte counts and cerebrovascular disease

Prentice, Ross L.; Szatrowski, Ted P.; Kato, Hiroo; Mason, Mark W.

doi:10.1016/0021-9681(82)90094-7

Cited by 139 publications

(72 citation statements)

References 16 publications

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“…Subjects with increased WBC count have excess risk of ischemic strokes independently of other cardiovascular risk factors [26]. Furthermore, WBC count has been shown to contribute to the initiation and further development of ischemic stroke [27,28].…”

Section: Discussionmentioning

confidence: 99%

Predictors of In-Hospital Mortality after Acute Ischemic Stroke in Subjects with and without Diabetes Mellitus

Papazafiropoulou¹,

Sotiropoulos²,

Skliros³

et al. 2009

TOGMJ

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Abstract:Background: Diabetes mellitus is a well-established risk factor for ischemic stroke and is associated with increased in-hospital mortality. The aim of the present study was to determine the potential predictors of in-hospital mortality after an ischemic stroke in diabetic and nondiabetic subjects. Methods: 159 diabetic subjects (66 males / 93 females, mean age ± SD: 77.4 ± 6.4 years) and 159 non diabetic subjects (66 males / 93 females, mean age ± SD: 77.3 ± 5.2 years) hospitalized for ischemic stroke were studied. Demographic characteristics and laboratory tests on admission as well as outcome were recorded. Brain computed tomography scan was performed in all study subjects. Results: In-hospital death rates did not differ between the diabetic and the nondiabetic patients [36 (22.6%) vs. 27 (17.0%), respectively, P = 0.20]. In the diabetic study group multivariate analysis, after controlling for CRP, total cholesterol, LDL-C, urea and creatinine levels, demonstrated that death was related with WBC count (OR: 1.002, 95% CI: 1.001-1.004, P = 0.005), glucose levels (OR: 1.007, 95% CI: 1.002-1.012, P = 0.008), and UA levels (OR: 1.51, 95% CI: 1.003-2.260, P = 0.05). In the nondiabetic study group, after controlling for WBC count, CRP, total cholesterol and LDL-C levels, death was related only with glucose levels (OR: 1.016, 95% CI: 1.001-1.031, P = 0.03). Conclusions: WBC count and UA levels on hospital admission are independent predictors for in-hospital mortality in diabetic subjects with ischemic stroke. Plasma glucose levels are predictor for in-hospital mortality in both diabetic and nondiabetic subjects.

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Section: Discussionmentioning

confidence: 99%

Predictors of In-Hospital Mortality after Acute Ischemic Stroke in Subjects with and without Diabetes Mellitus

Papazafiropoulou¹,

Sotiropoulos²,

Skliros³

et al. 2009

TOGMJ

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“…1 WBC count was associated with ischemic stroke in a previous prospective study of atomic bomb survivors, but potential confounding by smoking was not explored. 13 In a prospective study of US adults, Gillum found WBC count to be weakly associated with stroke, but not after adjustment for smoking. 14 Oxidant-generating stimuli (eg, smoking) raise the WBC count, and WBC counts contribute to blood viscosity, inflammation, and vascular injury through endothelial adhesion and by release of oxygen radicals and proteolytic enzymes.…”

Section: Folsom Et Al Hemostatic Factors and Ischemic Strokementioning

confidence: 99%

“…Yet, few prospective studies link these factors to risk of ischemic stroke. 2,3,8,9,[11][12][13][14][15] There appear to be no prospective data on the associations of factor VIII, antithrombin III (AT-III), protein C, or platelet count with incidence of ischemic stroke.…”

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confidence: 99%

Prospective Study of Markers of Hemostatic Function With Risk of Ischemic Stroke

Rosamond²,

et al. 1999

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for the Atherosclerosis Risk in Communities (ARIC) Study InvestigatorsBackground-Several markers of hemostatic function and inflammation have been associated with increased risk of coronary heart disease, but prospective evidence for their role in ischemic stroke is scant. Methods and Results-The Atherosclerosis Risk in Communities (ARIC) Study measured several of these markers in more than 14 700 participants 45 to 64 years old who were free of cardiovascular disease and were followed up for 6 to 9 years for occurrence of ischemic stroke (nϭ191). There was no apparent association between ischemic stroke incidence and factor VIIc, antithrombin III, platelet count, or activated partial thromboplastin time. After adjustment for multiple cardiovascular risk factors, von Willebrand factor, factor VIIIc, fibrinogen, and white blood cell count were positively associated and protein C was negatively but nonsignificantly associated with ischemic stroke incidence in regression analyses based on either continuous variables or fourths of the variable distributions. The adjusted relative risk (and 95% CI) for ischemic stroke in those in the highest versus lowest fourth were: von Willebrand factor, 1.71 (1.1 to 2.7); factor VIIIc, 1.93 (1.2 to 3.1); white blood cell count, 1.50 (0.9 to 2.4); fibrinogen, 1.26 (0.8 to 2.0); and protein C, 0.65 (0.4 to 1.0). Conclusions-This study offers modest support for the hypothesis that some markers of hemostatic function and inflammation can identify groups of middle-aged adults at increased risk of stroke. These factors may play a role in the pathogenesis of ischemic stroke. (Circulation. 1999;100:736-742.)

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“…The time frame for O/R in this nonhuman primate model is that which is being exploited in the clinical arena. It is possible that subtle effects on PMN leukocyte activation may occur, exclusive of alterations in absolute granulocyte count (Prentice et al, 1982;Harrison and Marshall, 1987), and that the subsequent cellu lar activation events may play a significant patho physiologic role in postischemic tissue injury. If preparation of the animal model alters leukocyte function, it is anticipated that the neuropathologic outcome of an experimental focal ischemic lesion will be altered.…”

mentioning

confidence: 99%

Polymorphonuclear Leukocyte Behavior in a Nonhuman Primate Focal Ischemia Model

Ember¹,

Zoppo

Mori

et al. 1994

J Cereb Blood Flow Metab

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Summary: There is increasing interest in the role of poly morphonuclear (PMN) leukocytes in the evolution of fo cal cerebral infarction. Surgical preparation of focal ce rebral ischemia models may alter leukocyte reactivity and thereby make interpretation of leukocyte function follow ing ischemiaireperfusion difficult. The effects of surgical preparation and of experimental ischemiaireperfusion on granulocyte function have been examined prospectively in a baboon model. Twenty-six adolescent male baboons underwent surgical preparation, of which 21 underwent middle cerebral artery occlusion/reperfusion. Four addi tional animals served as nonsurgical controls. Peripheral venous blood specimens were taken for performing as says of leukocyte function at defined intervals before and after both the surgical preparation (i.e., the overall pro cedure for implantation of the middle cerebral artery oc clusion device) and occlusionlreperfusion. A stress related elevation in total leukocyte number was attributed mainly to an increase in the number of circulating PMN leukocytes. Values rose from 13.9 ± 4.9 x 103 to 27.8 ± S.8 x 103/fLl, (±SD; n = 21) for total leukocyte number, withp < 0.001, and from 4.3 ± 2. 1 x 103 to IS.9 ± 4.7 x 103/fLi (n = 21) for PMN leukocytes, with p < 0.001.Polymorphonuclear (PMN) leukocytes may play an active and significant role in microvascular events (Ernst et aI

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Leukocyte counts and cerebrovascular disease

Cited by 139 publications

References 16 publications

Predictors of In-Hospital Mortality after Acute Ischemic Stroke in Subjects with and without Diabetes Mellitus

Predictors of In-Hospital Mortality after Acute Ischemic Stroke in Subjects with and without Diabetes Mellitus

Prospective Study of Markers of Hemostatic Function With Risk of Ischemic Stroke

Polymorphonuclear Leukocyte Behavior in a Nonhuman Primate Focal Ischemia Model

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