Leukocyte telomere length and prevalence of age-related diseases in semisupercentenarians, centenarians and centenarians' offspring

Nutritional Factors Modulating Alu Methylation in an Italian Sample from The Mark-Age Study Including Offspring of Healthy Nonagenarians

“…Most importantly, GO subjects do not display the reduction of Alu CpG1 methylation in the age-class 65.75 years compared to 55-64 years that was observed in RASIG. This finding could be the consequence of a delayed aging process in GO as observed in previous reports which support the theory of better preservation of several biological processes in centenarians' offspring [18,20,43,44]. Hence, the preservation of Alu CpG1 methylation level in GO supports the idea that this methylation site may be a potential biomarker of healthy aging.…”

“…Interestingly, GO subjects in the older age class showed a Alu CpG1 methylation similar to younger GO, but with a higher Alu CpG1 methylation level as compared to RASIG over 65 years old (Figure 1; p < 0.05). These results suggest that the age-related Alu CpG1 methylation decline is delayed in GO and this is consistent with the assumption that GO have a lower "biological" age than RASIG [19,20], As a consequence, Alu CpG1 methylation might be a potential biomarker of healthy aging for persons over 65 years.…”

“…Interestingly, hypomethylation and epigenetic age are delayed in centenarians' offspring [18,19], which are considered an optimal model to study biomarkers associated with human longevity. Indeed, centenarians' offspring show decreased epigenetic age of PBMCs than those of age matched controls [19,20] and display a greater genomic stability and lower DNA damage, that may contribute to explain their delayed onset of age-related diseases and prolonged survival [18]. In addition to a favorable genetic background that might delay hypomethylation, other studies show that other environmental and lifestyle factors such as smoking, alcohol consumption, physical activity, and diet [21,22], may influence Alu methylation in blood DNA.…”

Leukocyte telomere length is associated with advanced age-related macular degeneration in the Han Chinese population

“…Previous studies have reported that LTL is associated with cancers (Willeit et al, 2010;Martinez-Delgado et al, 2011;Lin et al, 2014;Ning et al, 2014) and age-related diseases (Kajstura et al, 2000;Armanios, 2013;Tedone et al, 2014). In our study, we investigated the relationship between LTL and AMD in a sample of 197 AMD patients and 259 healthy controls.…”

DNA Methylation in NFATC1 Gene Promoter is Related to Longevity in Chinese Population

“…Human lifespan is the outcome of complex interactions of environmental exposures, personal lifestyles and behaviors, and multiple genetic factors [1][2][3]. A number of longevity-related gene variants have been identified by genome-wide association studies during the past decade [4,5].…”