Leukotoxic Activity of Actinobacillus actinomycetemcomitans Isolated from Brazilian Periodontal Patients

Guazeli-Amin, V. H.; Ávila-Campos, Mário Júlio; Barbosa, Decio S; Gaetti‐Jardim, Elerson; Trevisan, Wilson; Itano, Eiko Nakagawa

doi:10.1006/anae.2000.0357

Cited by 3 publications

(3 citation statements)

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“…Some studies conducted in Brazil have found a high frequency of the JP2 clone of A. actinomycetemcomitans [ 46 , 47 ]; this overproducer of leukotoxin has been closely associated in some populations with AgP [ 48 ]. In our study, we attempted to determine the presence of this clone, although the sample amount only allowed for testing four A. actinomycetemcomitans- positive samples (data not shown).…”

Section: Discussionmentioning

confidence: 99%

Periodontal pathogens and tetracycline resistance genes in subgingival biofilm of periodontally healthy and diseased Dominican adults

et al. 2015

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ObjectiveThe objective of this study was to compare the periodontopathogen prevalence and tetracycline resistance genes in Dominican patients with different periodontal conditions.MethodsSeventy-seven samples were collected from healthy, gingivitis, chronic (CP) and aggressive (AgP) periodontitis patients. Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Prevotella intermedia, Parvimonas micra, Eikenella corrodens and Dialister pneumosintes and 11 resistance genes were studied by PCR. P. gingivalis fimA genotype was determined.ResultsIn healthy patients, P. micra and P. intermedia were the most and least frequently detected, respectively. T. forsythia and E. corrodens appeared in 100 % of gingivitis patients. Red complex, D. pneumosintes and E. corrodens were significantly more prevalent in CP compared to healthy patients. F. nucleatum and T. denticola were detected more frequently in AgP. A. actinomycetemcomitans was the most rarely observed in all groups. The fimA II genotype was the most prevalent in periodontitis patients. Seven tetracycline-resistant genes were detected. tet(Q), tet(32) and tet(W) showed the greatest prevalence. tet(32) was significantly more prevalent in CP than in healthy patients.ConclusionsRed complex bacteria and D. pneumosintes were significantly the most prevalent species among periodontitis patients. T. forsythia was the most frequently detected in this population. To our knowledge, this is the first study describing the tet(32) gene in subgingival biofilm from healthy and periodontally diseased subjects.Clinical relevanceThis study contributes to the knowledge on the subgingival microbiota and its resistance genes of a scarcely studied world region. Knowing the prevalence of resistance genes could impact on their clinical prescription and could raise awareness to the appropriate use of antibiotics.Electronic supplementary materialThe online version of this article (doi:10.1007/s00784-015-1516-2) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Periodontal pathogens and tetracycline resistance genes in subgingival biofilm of periodontally healthy and diseased Dominican adults

et al. 2015

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“…In chronic periodontitis, the prevalence of A. actinomycetemcomitans periodontitis was 18% with a predominance of biotype II . Leukotoxic strains of A. actinomycetemcomitans (JP2 clone, serotype b) were a common finding in aggressive periodontitis in South America, with a particularly high prevalence in Brazil . Cortelli et al.…”

Section: Periodontal Microbiology In Latin Americamentioning

confidence: 98%

“…Overall, the chlorhexidine rinse treatment showed a significant reduction in the proportions of red and orange bacterial complexes nance of biotype II (125). Leukotoxic strains of A. actinomycetemcomitans (JP2 clone, serotype b) were a common finding in aggressive periodontitis in South America, with a particularly high prevalence in Brazil (84,161). Cortelli et al (42) found a higher occurrence of A. actinomycetemcomitans and of highly leukotoxic strains in Brazil than in other South American countries, and linked highly leukotoxic strains to a greater loss of periodontal attachment compared with minimally leukotoxic strains.…”

Section: Fernandes Et Al (2010) (71)mentioning

confidence: 99%

Periodontal microbiology in Latin America

Contreras¹,

Moreno²,

Jaramillo³

et al. 2014

Periodontology 2000

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This review article describes the microbiota associated with periodontal disease in Latin America. This vast territory includes 22 nations, which show great ethnic diversity, with large groups of White people, Black people, Mestizo people and Native people. Widespread poverty and limited access to education and health-care services, including periodontal care, are prominent predisposing factors for destructive periodontal disease in Latin America. Black people and Mestizo people seem to have particularly severe periodontal disease and are frequently colonized by the major periodontal pathogens Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans. The 'red complex' bacterial pathogens and A. actinomycetemcomitans predominate in chronic and aggressive periodontitis, but gram-negative enteric rods and herpesviruses can also play important periodontopathic roles in Latin America. The key to minimizing the risk of periodontal disease is control of the pathogens, and new low-cost periodontal treatments deserve serious consideration in Latin America.

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Characterization of leukotoxin from a clinical strain of Actinobacillus actinomycetemcomitans

Diaz

Ghofaily

Patel

et al. 2006

Microbial Pathogenesis

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Leukotoxic Activity of Actinobacillus actinomycetemcomitans Isolated from Brazilian Periodontal Patients

Cited by 3 publications

References 19 publications

Periodontal pathogens and tetracycline resistance genes in subgingival biofilm of periodontally healthy and diseased Dominican adults

Periodontal pathogens and tetracycline resistance genes in subgingival biofilm of periodontally healthy and diseased Dominican adults

Periodontal microbiology in Latin America

Characterization of leukotoxin from a clinical strain of Actinobacillus actinomycetemcomitans

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