Levamisole and Leucocyte Migration into Sponge Exudates

Abstract

Locally administered levamisole enhanced leucocyte migration into inert sponges implanted into rats for either 4 or 48 h. The stimulated cell at both times was predominantly the polymorphonuclear neutrophil. Locally administered levamisole also enhanced leucocyte migration into inert sponges implanted into arthritic rats, during the primary stage as well as during the secondary stage after adjuvant injection when arthritis had been fully established.

Effects of Levamisole and <i>D</i>-Penicillamine on Leucocyte Migration into Sponge Exudates in Rats

“…A preliminary report on the effect of levamisole on leucocyte migration in to sponge exudates of normal and arthritic rats has al ready been published [6]. In our hands, NR rats do not exhibit arthritis after adjuvant injections when R rats show disseminated arthritic lesions.…”

Skin Reactions of Rats to Levamisole and <i>D</i>-Penicillamine

“…This species resistance in skin sensitiza tion has to be viewed in the light of the ob servation that locally administered levami sole enhanced leucocyte migration into inert sponges implanted into both R and NR rats at both 4 and 48 h [2], However, there was no preferential mononuclear infiltration in this previous study which was carried out using much higher doses of levamisole (5 mg) in both control R and NR rats and in arthritic R rats.…”

Forty Years of Pharmacological Research

“…However, in arthritic rats, both antiarthritic drugs greatly stimulated leukocyte migration. into inert sponges when the disease was well established and migration had been markedly reduced by the disease (Griffiths & West 1980). It is possible, therefore, that both drugs directly stimulate lymph node cells to mitosis and restore chemotactic responsiveness which occurs in certain diseases.…”