Levan-based nanostructured systems: An overview

Siqueira, Edmilson Clarindo de; Rebouças, Juliana de Souza; Pinheiro, Irapuan Oliveira; Formiga, Fabio Rocha

doi:10.1016/j.ijpharm.2020.119242

Cited by 44 publications

(23 citation statements)

References 51 publications

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“…In nonsterile, highly saline conditions, Halomonas smyrnensis cultures were the first extremophilic levan producers that provided high yields and were cost-effective. Moreover, bacteria from the genera Bacillus, Acinetobacter, Acetobacter, Pseudomonas, and Zymomonas are also known to produce levan . It is an amphiphilic polymeric material able to form films with high adhesion properties and is compatible with salts and surfactants.…”

Section: Microbial Polysaccharidesmentioning

confidence: 99%

“…Moreover, bacteria from the genera Bacillus, Acinetobacter, Acetobacter, Pseudomonas, and Zymomonas are also known to produce levan. 38 It is an amphiphilic polymeric material able to form films with high adhesion properties and is compatible with salts and surfactants. In addition, it exhibits biocompatibility, nontoxicity, stability in heat, acidic, and alkaline media, and high water holding capacity.…”

Section: Microbial Polysaccharidesmentioning

confidence: 99%

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Microbial Polysaccharide-Based Nanoformulations for Nutraceutical Delivery

Srivastava

Choudhury

2022

ACS Omega

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In recent times, nutrition and diet have become prominent health paradigms due to sedentary lifestyle disorders. Preventive health care strategies are becoming increasingly popular instead of treating and managing diseases. A nutraceutical is an innovative concept that offers additional health benefits beyond its fundamental nutritional value. These nutraceuticals have the potential to reduce the exorbitant use of synthetic drugs because the modern medicine approach of treating diseases with high-tech, expensive supplements, and long-term consequences aggravates consumers. However, most nutraceuticals are plant-derived, making them susceptible to degradation and prone to chemical instability, poor solubility, unpleasant taste, and bioactivity loss before absorption to the targeted site. To counteract this problem, the bioavailability of these labile compounds can be maximized by encapsulating them in protective nanocarriers. It is crucial that nanoencapsulation technologies convert bioactive compounds into forms that can be easily combined with functional foods and beverages without adversely affecting their organoleptic properties. In recent years, nanoformulations using food-grade materials, such as polysaccharides, proteins, lipids, etc., have received considerable attention. Among them, microbial polysaccharides are biocompatible, nontoxic, and nonimmunogenic, and most of them are US-FDA approved and can undergo tailored modifications. The nanoformulation of microbial polysaccharide is a relatively new frontier which has several advantages over existing systems. The present article, for the first time, comprehensively reviews microbial polysaccharides-based nanodelivery systems for nutraceuticals and discusses various techno-commercial aspects of these nanotechnological preparations. Moreover, this has also attempted to draw a future research perspective in this area.

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Section: Microbial Polysaccharidesmentioning

confidence: 99%

Section: Microbial Polysaccharidesmentioning

confidence: 99%

Microbial Polysaccharide-Based Nanoformulations for Nutraceutical Delivery

Srivastava

Choudhury

2022

ACS Omega

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“…Synchronized laser evaporation of cryogenic targets containing sulfated Halomonas levan (SHL) and quaternized low molecular weight chitosan (QCH) revealed successful fabrication of combinatorial gradient bio-coatings. Studies have shown that levan polysaccharides are highly efficient in several biomedical applications such as antioxidant and anticancer activities, drug carrier systems, bioactive thin film blends, multilayer adhesive films, but also temperature responsive and cytocompatible hydrogels [153][154][155][156]. Recently, SHL has shown heparin mimetic anticoagulant activity [157] as well as improved mechanical and adhesive properties of cytocompatible and myoconductive films for cardiac tissue engineering applications [158].…”

Section: Multi-functional Organic Bio-coatings Obtained By C-maplementioning

confidence: 99%

Biomimetic Coatings Obtained by Combinatorial Laser Technologies

Axente

Sima

2020

Coatings

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The modification of implant devices with biocompatible coatings has become necessary as a consequence of premature loosening of prosthesis. This is caused mainly by chronic inflammation or allergies that are triggered by implant wear, production of abrasion particles, and/or release of metallic ions from the implantable device surface. Specific to the implant tissue destination, it could require coatings with specific features in order to provide optimal osseointegration. Pulsed laser deposition (PLD) became a well-known physical vapor deposition technology that has been successfully applied to a large variety of biocompatible inorganic coatings for biomedical prosthetic applications. Matrix assisted pulsed laser evaporation (MAPLE) is a PLD-derived technology used for depositions of thin organic material coatings. In an attempt to surpass solvent related difficulties, when different solvents are used for blending various organic materials, combinatorial MAPLE was proposed to grow thin hybrid coatings, assembled in a gradient of composition. We review herein the evolution of the laser technological process and capabilities of growing thin bio-coatings with emphasis on blended or multilayered biomimetic combinations. These can be used either as implant surfaces with enhanced bioactivity for accelerating orthopedic integration and tissue regeneration or combinatorial bio-platforms for cancer research.

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“…Levan is a group of fructans differentiated by their β(2,6) glycosidic bonds and laterally branched β(2,1) bonds that are synthesized by many types of bacteria, such as Bacillus spp., Zymomonas spp., and Halomonas sp. , Only one study investigated levan as the main component of solid electrolytes. Jo et al developed a polymer electrolyte based on levan and choline and malate-based RTIL .…”

Section: Bacterial-polymer-based Electrolytesmentioning

confidence: 99%

Bacterial-Polymer-Based Electrolytes: Recent Progress and Applications

Torres

De-la-Torre

Gonzales

et al. 2020

ACS Appl. Energy Mater.

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Bacteria can naturally synthesize a wide range of biopolymers that have appealing material properties for numerous applications. In the past decade, the development of green electronics based on bacterial polymers has gained major attention. Polymer electrolytes are key components in electrochemical devices owing to their mechanical properties, thermal stability, and ionic conductivity. The present review focuses on the recent progress of bacterial-polymer-based electrolytes and their applications in electrochemical energy conversion and storage. First, we described the ion transfer mechanism of polymer electrolytes and the multiple approaches for improving ionic conductivity and mechanical properties. Then, we summarized the composition, performance, and approaches applied for the development of multiple bacterial polymer electrolytes, namely, polysaccharides, polyanhydrides, and polyesters. Lastly, the practical applications of bacterial-polymer-based electrolytes in electrochemical energy storage and conversion, namely, fuel cells, batteries, supercapacitors, and other electrochemicals, are reviewed. Bacterial polymer electrolytes are presented as a fruitful, eco-friendly, and high-performance alternative for traditional solid polymer electrolytes.

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Levan-based nanostructured systems: An overview

Cited by 44 publications

References 51 publications

Microbial Polysaccharide-Based Nanoformulations for Nutraceutical Delivery

Microbial Polysaccharide-Based Nanoformulations for Nutraceutical Delivery

Biomimetic Coatings Obtained by Combinatorial Laser Technologies

Bacterial-Polymer-Based Electrolytes: Recent Progress and Applications

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