Level of CD14+-endothelial progenitor cells is not associated with coronary artery disease or cardiovascular risk factors

Hu, Teng; Qiang, Sheng; Jiang, Yi; Li, Su; Yin, Yuehui

doi:10.1007/s11357-008-9074-z

Cited by 6 publications

(7 citation statements)

References 33 publications

(69 reference statements)

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“…Mobilisation of CD14 + VEGFR-2 + monocytes following MI has been reported previously in a small clinical study by Bruno et al ,26 who also demonstrated that intramyocardial injection of CD14 + VEGFR-2 + cells improved ventricular function in a murine model of MI. By contrast, Hu et al 27 found no difference in CD14 + VEGFR-2 + cells between patients with stable or unstable CAD and healthy controls, however, this study assessed only 25 patients, 2 weeks post-ACS, and troponin concentrations were not reported making direct comparisons with our study difficult. We believe proangiogenic monocytes are mobilised in the acute response to cardiovascular stress, and may be a measure of myocardial rather than vascular or endothelial injury.…”

Section: Discussioncontrasting

confidence: 71%

Endothelial progenitor cells, atheroma burden and clinical outcome in patients with coronary artery disease

Padfield

Tura-Ceide

Freyer

et al. 2013

Heart

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Section: Discussioncontrasting

confidence: 71%

Endothelial progenitor cells, atheroma burden and clinical outcome in patients with coronary artery disease

Padfield

Tura-Ceide

Freyer

et al. 2013

Heart

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“…Several measures have been found to increase mobilization of PCs, such as lifestyle modification, intensifying statin therapy, cilostazol, and exercise. 31, 50,25, 26 Thus, identifying subjects at risk for PAD may allow for earlier interventions, and potentially abrogation of that risk. A low CD34+/VEGF2R+ PC cell count is indicative of worse long term prognosis, especially from vascular events.…”

Section: Discussionmentioning

confidence: 99%

“…25–27 We and others have also shown that lower circulating PC levels in patients with CAD is associated with an increased risk of adverse CAD events. 28, 29 Previous studies investigating the role of PCs in diabetics with PAD found significantly decreased CD34+/VEGFR2+ cell counts and proliferation compared to healthy or diabetic subjects without PAD.…”

Section: Introductionmentioning

confidence: 92%

Circulating Progenitor Cells Identify Peripheral Arterial Disease in Patients With Coronary Artery Disease

Hayek

MacNamara

Tahhan

et al. 2016

Circulation Research

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Rationale Peripheral arterial disease (PAD) is a clinical manifestation of extra-coronary atherosclerosis. Despite sharing the same risk factors, only 20–30% of patients with coronary artery disease (CAD) develop PAD. Declines in the number of bone-marrow derived circulating progenitor cells (PCs) is thought to contribute to the pathogenesis of atherosclerosis. Whether specific changes in PCs differentiate patients with both PAD and CAD from those with CAD alone is unknown. Objective Determine whether differences exist in PCs counts of CAD patients with and without known PAD. Methods and Results 1497 patients (mean age 65, 62% male) with known CAD were identified in the Emory Cardiovascular Biobank. Presence of PAD (n=308) was determined by history, review of medical records or imaging, and was classified as carotid (53%), lower extremity (41%), upper extremity (3%) and aortic disease (33%). Circulating PCs were enumerated by flow cytometry. Patients with CAD and PAD had significantly lower PC counts compared to those with only CAD. In multivariable analysis, a 50% decrease in CD34+ or CD34+/VEGFR2+ counts were associated with a 31% (P=0.032) and 183% (P=0.002) increase in the odds of having PAD, respectively. CD34+ and CD34+/VEGFR2+ counts significantly improved risk prediction metrics for prevalent PAD. Low CD34+/VEGFR2+ counts were associated with a 1.40-fold (95%CI, 1.03, 1.91) and a 1.64-fold (95%CI 1.07, 2.50) increase in the risk of mortality and PAD-related events, respectively. Conclusions PAD is associated with low CD34+ and CD34+/VEGFR2+ PC counts. Whether low PC counts are useful in screening for PAD needs to be investigated.

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“…14–20 Lower circulating PC counts and impaired PC activity measured by colony forming and migration assays have been reported in subjects with RFs for CVD in some but not all studies. 21–23 It is also unclear in humans whether aging alters circulating PC numbers, whether exposure to the injurious effects of CVD RFs stimulates or inhibits PC, and whether presence of atherosclerotic CVD is associated with impairment of PC. Our aim was to investigate the relationship between healthy aging, and aging with exposure to CVD RFs or with established CVD, on circulating PC levels.…”

Section: Introductionmentioning

confidence: 99%

Age and Human Regenerative Capacity Impact of Cardiovascular Risk Factors

Mheid

Hayek

et al. 2016

Circulation Research

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Rationale We investigated aging of human endogenous reparative capacity and aimed to clarify whether it is affected by presence of cardiovascular disease or its risk factors. Objective Circulating progenitor cell (PC) levels reflect endogenous regenerative potential. The effect on PC of healthy aging compared to aging with risk factors (RF) or cardiovascular disease (CVD) is unknown. We examined whether exposure to RF and CVD leads to an accelerated decline in circulating PC with increasing age. Methods and Results In 2,792 adult subjects, 498 were free of RFs (smoking, diabetes, hypertension or hyperlipidemia); 1036 subjects had 1–2 RF, and 1253 had ≥3 RFs and/or CVD. PC were enumerated by flow cytometry as CD45med+ mononuclear cells expressing CD34 and subsets co-expressing CD133, CXCR4, and vascular endothelial growth factor receptor-2 (VEGF2R) epitopes. Younger age, male gender and larger body size correlated with higher PC counts (p<0.01). After multivariable adjustment, both age and RF categories were independently associated with PC counts (p<0.05), with lower PC counts in older subjects and those with higher RF burden or CVD. PC counts remained unchanged with increasing age in healthy individuals. There were significant interactions between age and RF categories (p≤0.005), such that for younger subjects (<40 years), RFs were associated with increased PC counts, whereas for older subjects (>60 years), RFs and CVD were associated with lower PC counts. Conclusion Circulating PC levels do not decline with healthy aging; RF exposure at a younger age stimulates PC mobilization whereas continued exposure is associated with lower PC levels in later life. Over the lifespan, exposure to RFs and CVD is associated with an initial stimulation and subsequent decline in circulating PC levels, which reflect endogenous regenerative capacity.

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Level of CD14+-endothelial progenitor cells is not associated with coronary artery disease or cardiovascular risk factors

Cited by 6 publications

References 33 publications

Endothelial progenitor cells, atheroma burden and clinical outcome in patients with coronary artery disease

Endothelial progenitor cells, atheroma burden and clinical outcome in patients with coronary artery disease

Circulating Progenitor Cells Identify Peripheral Arterial Disease in Patients With Coronary Artery Disease

Age and Human Regenerative Capacity Impact of Cardiovascular Risk Factors

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