Level of Indoor Allergens in Dust from Homes of Allergic and Non-Allergic Individuals

Schwartz, B.; Lind, Peter; Løwenstein, H.

doi:10.1159/000234250

Cited by 18 publications

(8 citation statements)

References 3 publications

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“…In this study, we used a sandwich ELISA with monoclonal antibodies against Der p 1, Der f 1, Der 2, Lep d 1, and Fel d 1 (33,34) to quantify the content of these allergens in the house-dust extracts from our patients' homes. We found D. pteronyssinus to be predominant over D. farinae, in concordance with other European studies (25,28,37), but unlike estimations in some North American papers (27,39). This result is probably related to the climate of our area; we do not have long dry winters, the chmatic pattern that seems to favor D. farinae predominance (20).…”

Section: Discussionsupporting

confidence: 92%

Quantitation of major allergens in dust samples from urban populations collected in different seasons in two climatic areas of the Basque region (Spain)

Echechipía

Ventas

Audícana

et al. 1995

Allergy

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We present the results of allergen content evaluation in 80 dust samples from 31 homes of atopic patients from two climatic areas (humid and subhumid), collected in two seasons of the year (autumn and winter). Monoclonal antibody-based immunoassays were used to quantify Der p 1, Der f 1, Der 2, Lep d 1, and Fel d 1. The results were compared according to climate, season, and the type of sensitization (Pyroglyphidae mites, storage mites, or grass pollens). We underline the predominance of Dermatophagoides pteronyssinus (89% of samples) over D. farinae (16% of samples) in our environment. Der p 1 rates were higher in the humid area (Mann-Whitney P < 0.001), especially in the autumn (Wilcoxon P < 0.05). Lep d 1 was detected in 23% of samples and Lep d 1 levels were higher in the homes of patients sensitized to storage mites (Mann-Whitney P < 0.05), whereas this allergen was not detected in the homes of pollen-allergic patients. Fel d 1 was detected in nine of the 31 homes (16% of samples) although there was a cat in only one home.

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Section: Discussionsupporting

confidence: 92%

Quantitation of major allergens in dust samples from urban populations collected in different seasons in two climatic areas of the Basque region (Spain)

Echechipía

Ventas

Audícana

et al. 1995

Allergy

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“…Atopic patients have the ability to produce IgE to a variety of allergens. This is believed to be in response to exposure to these allergens in the environment although the importance ofthe magnitude, duration and timing of this exposure is not clear [10,[21][22][23]. Many studies (including our own) using RAST, RAST inhibition or Western blotting techniques have shown that subjects differ in their IgE response to house dust mite allergens [8][9][10].…”

Section: Discussionmentioning

confidence: 99%

House dust mite sensitivity: a comparison of immune response with exposure to four species of Pyroglyphidae

Young

Hart

Faux

et al. 1990

Clin Experimental Allergy

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Twenty-five atopic children under 11 years of age were studied, using skin and RAST tests, for their specific IgE response to four species of pyroglyphid house dust mites, Dermatophagoides pteronyssinus, D. farinae, D. microceras and Euroglyphus maynei. All of the children were sensitive to D. pteronyssinus, 20 (80%) of these children were also sensitive to D. farinae and D. microceras, and 16 of the latter (64%) were also sensitive to E. maynei. Dust samples from various sites in the homes of the children revealed D. pteronyssinus in all homes studied but no D. farinae or D. microceras. E. maynei, although identified, was not present in significant numbers in any site. A control group of 20 atopic children of similar age who were not sensitive to house dust mite allergens had a similar exposure to the four mite species. These results suggest that factors in addition to mite exposure are important in the development of specific IgE responses to house dust mites.

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“…Thirdly, seasonal differences between the summer and autumn of 1990 compared with these seasons in 1991 could have been a partial cause for the year-to-year variation observed. Following the relatively [15,22] high allergen concentrations in the first survey (>2 fig/g: 43-8% of households regarding Der p I and 54-1% regarding Derfl), the further increase in concentrations in the second survey for both antigens might be a consequence of even more 'favourable' conditions from winter 1990/1991 to summer 1991, compared with the previous year. Regarding fiuctuations within one sampling period, in comparison with the literature [8,10], only a minor month-to-month variation of mite antigen load could be seen in our study region.…”

Section: Year-to-year Variationmentioning

confidence: 96%

Natural variation in mite antigen density in house dust and relationship to residential factors

Kuehr

Frischer

Karmaus

et al. 1994

Clin Experimental Allergy

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To investigate the year-to-year variation of mite antigen density (Der p I, Der fI) in dust from mattresses and the relevance of residential factors for antigen load, information derived from an epidemiologic study including two surveys carried out in the households of a cohort of elementary school children (n = 1291) was analysed. When considering residences with measurements taken in both years in question (n = 1050), rank-correlation indicated a predominance of stability for both antigens (Der p I: rs = 0.82, P = 0.0001; Der f I: rs = 0.72, P = 0.0001). Using multiple regression analyses, significant associations between antigen concentrations and a variety of residential factors were found. Use of a blanket of animal hair, use of a cover or underblanket, wet spots in the bedroom, higher relative humidity and a low storey level were significantly associated with increased concentrations of Der p I, whereas inverse relationships between this antigen and room temperature, number of persons per m2 as well as use of underfloor heating were seen. Regarding Der fI, older mattresses, use of a cover or underblanket, higher weight of sampled dust, high educational level and higher ratio of inhabitants per m2 were significantly associated with increased concentrations of the antigen. On the other hand, lower Der fI concentrations were found when interior sprung mattresses were used and when the mattress was 'treated regularly'. In conclusion, two measurements, 1 year apart from each other, show that stability of mite antigen concentrations predominated.(ABSTRACT TRUNCATED AT 250 WORDS)

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Level of Indoor Allergens in Dust from Homes of Allergic and Non-Allergic Individuals

Cited by 18 publications

References 3 publications

Quantitation of major allergens in dust samples from urban populations collected in different seasons in two climatic areas of the Basque region (Spain)

Quantitation of major allergens in dust samples from urban populations collected in different seasons in two climatic areas of the Basque region (Spain)

House dust mite sensitivity: a comparison of immune response with exposure to four species of Pyroglyphidae

Natural variation in mite antigen density in house dust and relationship to residential factors

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