Level of Neutrophil Gelatinase-Associated Lipocalin (Ngal) Urin as a Predictor of Acute Kidney Injury in Sepsis Patients Treated in Icu H.ADAM Malik Medan Hospital

Abstract

BACKGROUND: Sepsis is a complex interaction between the direct toxic effects of infecting microor ganisms and the disruption of the host's normal inammatory response to infection. One organ that is often disrupted is the kidney . Neutrophil Gelatinase-Associated Lipocalin (NGAL) is an AKI biomarker that can be used as an early biomarker for AKI prediction, monitoring clinical trials in AKI and for the prognosis of AKI. METHOD: This research is an observational study. 30 subjects with sepsis were examined for PCT, BUN, urea, creatinine and urine NGAL tests. RESULTS: Statistical analysis using the Spearman Rank Test shows that NGAL level 1 has a signicant relationship with PCT day 1, with a value (r = 0.912) and a value of p <0.05. NGAL level day 1 did not have a signicant relationship with levels of urea, creatinine, BUN with values (r = 0.113), (r = 0.329), (r = 0.352) and values (p> 0.05). NGAL day 3 had a signicant relationship with PCT day 1, with a value (r = 0.0771) and a p value <0.001. Measurement of NGAL day 3 had a signicant relationship with urea, creatinine, BUN, and values (r = 0.427), (r = 0.550), (r = 0.411) with a p value <0.05. CONCLUSIONS AND RECOMMENDATIONS: From the results of the study, it was concluded that there was a difference between urine NGAL levels in septic patients on day 1 (197.26 ± 118.54) and day 3 (288.31 ± 136.96). There was a signicant correlation between urinary NGAL levels with urea levels (p = 0.024 & r = 0.427) and creatinine (p = 0.002 & r = 0.550) on day 3, so urine NGAL was a predictor of AKI events in sepsis patients on day 1 -3..