Levels and determinants of urinary cadmium in general population in Spain: Metal-MCC-Spain study

Muñoz, Julia Blanco; Lope, Virginia; Larrea-Baz, Nerea Fernández de; Gómez‐Ariza, José Luis; Dierssen-Sotos, Trinidad; Fernández‐Tardón, Guillermo; Aragonés, Núria; Amiano, Pilar; Gómez‐Acebo, Inés; Tardón, Adonina; Grau-Pérez, María; García‐Barrera, Tamara; Kogevinas, Manolis; Pollán, Marina; Pérez‐Gómez, Beatriz

doi:10.1016/j.envres.2022.112959

Cited by 6 publications

(2 citation statements)

References 58 publications

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“…Women are found to have higher urinary cadmium than men. This discrepancy has been observed in some previous observational studies (10,17). In general, due to higher estrogen levels, women tend to share a lower risk of kidney stones than men (18).…”

Section: Discussionmentioning

confidence: 65%

National analysis of urinary cadmium concentration and kidney stone: Evidence from NHANES (2011–2020)

Zai-zhi

Luo

et al. 2023

Front. Public Health

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BackgroundThe association between urinary cadmium and kidney stone risk is inconsistent in previous studies, which needs further exploration. This study was performed to explore the association between urinary cadmium and kidney stone.Materials and methodsData from the National Health and Nutrition Examination Survey (2011–2020) were included and further analyzed. Urinary cadmium was stratified into quartiles with quartile 1 (Q1: 0.025–0.104 μg/L) and quartile 4 (Q4: 0.435–7.581 μg/L). Further weighted logistic regression was adopted to evaluate the association between urinary cadmium and kidney stone. A subgroup analysis was used to verify the findings. The non-linear association was examined using the restricted cubic spline (RCS) regression.ResultsA total of 9,056 adults aged 20 years and above were included in this study. In the fully adjusted model, an increased risk of kidney stones was identified for quartile 2 (OR = 1.40, 95% CI = 1.06–1.84, P < 0.05), quartile 3 (OR = 1.18, 95% CI = 0.88–1.59, P > 0.05), and quartile 4 (OR = 1.54, 95% CI = 1.10–2.06, P < 0.05). A similar association was found between continuous cadmium increase and OR of kidney stones in the fully adjusted model (OR = 1.13, 95% CI = 1.01–1.26, P < 0.05). The RCS also indicated a non-linear association between urinary cadmium concentration and kidney stone risk (P for non-linear < 0.001).ConclusionIn summary, cadmium exposure is identified as a risk factor for kidney stones in this study. Their non-linear association makes demands on early intervention for the cadmium-exposed population. Medical interventions for kidney stone prevention should take cadmium exposure into account.

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Section: Discussionmentioning

confidence: 65%

National analysis of urinary cadmium concentration and kidney stone: Evidence from NHANES (2011–2020)

Zai-zhi

Luo

et al. 2023

Front. Public Health

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“…Cd, As, Pb, and Hg, referred to as CALM in this chapter, are closely linked to hypertension, neurological disorders, cognitive impairments, cerebral palsy, blindness, dysarthria, cancers, cirrhosis, and hyperkeratosis [8][9][10][11][12]. These metals, albeit in excessive concentrations and exposure, have no known health benefits in human physiology and are thus considered toxicants [13,14]. Further, accumulation of CALM in the body may lead to a steady reduction in intelligence quotient (I.Q.)…”

Section: Introductionmentioning

confidence: 99%

Occurrences of Cadmium, Arsenic, Lead, and Mercury in Potable Water in Greater Gaborone, Botswana: Implications for Public Health

Mbongwe,

T. Odirile,

Letsholo

et al. 2024

Poisoning - Prevention, Diagnosis, Treatment and Poison Repurposing

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Heavy metals, such as cadmium (Cd), arsenic (As), lead (Pb), and mercury (Hg), are often detected in water, causing detrimental effects to human health. This study assessed Cd, As, Pb, and Hg concentrations in drinking water from the greater Gaborone water distribution system supply area. The Inductively Coupled Plasma—Mass spectrometry was used to analyze 200 water samples from water treatment reservoirs, the distribution line, households, and bottled water. Heavy metal pollution was calculated using the heavy metal pollution index (HPI). Average heavy metal concentrations were in the order of Pb > Hg > As > Cd in the overall study, with lead exceeding the permissible limit set by the United States Environmental Protection Agency (US-EPA) in all the samples. Average lead concentrations from indoor taps were 15 times more than untreated raw water. HPI values were respectively 33.2 and 0.74 for the World Health Organization (WHO) and Botswana Bureau of Standards (BOBS). An increase in heavy metal concentrations post-water treatment suggests inadequate system maintenance and possible contamination of water during the distribution system from copper and lead soldered pipes. Further research on the treatment infrastructure and plumbing activities is suggested.

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Urinary cadmium and peripheral blood telomere length predict the risk of renal function impairment: a study of 547 community residents of Shanxi, China

Zhang

Guo

et al. 2022

Environ Sci Pollut Res

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Levels and determinants of urinary cadmium in general population in Spain: Metal-MCC-Spain study

Cited by 6 publications

References 58 publications

National analysis of urinary cadmium concentration and kidney stone: Evidence from NHANES (2011–2020)

National analysis of urinary cadmium concentration and kidney stone: Evidence from NHANES (2011–2020)

Occurrences of Cadmium, Arsenic, Lead, and Mercury in Potable Water in Greater Gaborone, Botswana: Implications for Public Health

Urinary cadmium and peripheral blood telomere length predict the risk of renal function impairment: a study of 547 community residents of Shanxi, China

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