Levels of Apolipoprotein A1, B100  and Lipoprotein (a) in Controlled and  Uncontrolled Diabetic Patients and in Non-Diabetic Healthy People

Patel, Vishwal Indravadan; Patel, Kaustubh; Makadia, Mayur Goradhanbhai; Shah, Aashna Darshanbhai; Chaudhari, K. S.; Nilayangode, Haridas Neelakandan

doi:10.7860/jcdr/2017/22741.9258

Cited by 9 publications

(9 citation statements)

References 32 publications

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“…Isolated Triglyceride levels shows a positive correlation with age (r=0.219; p= 0.000), Gender (0.076; p=0.008), HbA1C (r=0.104; p=0.00) as shown in Multifactorial disorders such as diabetes present a wide range of lipid abnormalities. Among T2DM individuals, the incidence of hyper triglyceride was high when compared to other lipid abnormalities (14,15). The current study highlighted the existence of significant correlation among HbA1C, Gender, and age with hypertriglyceridemia.…”

Section: Resultssupporting

confidence: 49%

Hypertriglyceridemia and its association with Glycated Hemoglobin in Type 2 Diabetes Mellitus – A cross sectional study

Balaji¹,

Balaji²,

Balaji³

et al. 2021

IJSRP

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Globally, diabetes mellitus is a common health problem. People with diabetes are at a greater risk of developing cardiovascular disease due to dyslipidaemia. The aim of the present study was to determine the association of Hypertriglyceridemia and Glycated hemoglobin among T2DM individuals. The retrospective, observational study was conducted among T2DM patients with isolated Triglyceride from January 2020 to Oct 2021. A total of 1248 T2DM individuals with Hypertriglyceridemia were included in the study and were assessed for isolated hyper triglyceride and Glycated haemoglobin (HbA1C). Of 1248 patients, 801 (64.18%) were males and 447 were female (35.81%). The mean age, duration of diabetes and HbA1C was 56.873±12.3years, 15.87±5.92 years and 8.53±1.78% respectively. There exist a significant difference in isolated hyper triglyceride among the various age groups, gender and HbA1C. Isolated Triglyceride levels shows a positive correlation with age (r=0.219; p= 0.000), Gender (0.076; p=0.008), HbA1C (r=0.104; p=0.00). The current study finding highlighted that there is a significant association between Hypertriglyceridemia and Glycated haemoglobin in T2DM individuals. The proper control of Glycated haemoglobin might prevent the predisposition of isolated triglyceride and reducing the risk of cardiovascular disease.

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Section: Resultssupporting

confidence: 49%

Hypertriglyceridemia and its association with Glycated Hemoglobin in Type 2 Diabetes Mellitus – A cross sectional study

Balaji¹,

Balaji²,

Balaji³

et al. 2021

IJSRP

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“…This is not surprising, as SEC method isolates nanoparticles based on size and many lipoproteins (LDLs, VLDLs and chylomicrons) and also larger protein aggregates 37 are in the same size-range as EVs 38 . Moreover, lipoproteins are approximately 10 7 -fold more abundant in human blood plasma than EVs 7 , 9 , with reported concentrations of ApoA1 and ApoB100 in healthy adults of 189.11 × 10 4 ng/mL and 147.25 × 10 4 ng/mL, respectively 39 . We have shown that high concentrations of ApoA1 (median value: 1.1 × 10 4 ng/mL) and ApoB100 (median value: 2.6 × 10 4 ng/mL) are present in the sample even after enrichment of EVs with SEC.…”

Section: Discussionmentioning

confidence: 99%

Enrichment of plasma extracellular vesicles for reliable quantification of their size and concentration for biomarker discovery

Holcar

Ferdin

Sitar

et al. 2020

Sci Rep

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Human plasma is a complex fluid, increasingly used for extracellular vesicle (EV) biomarker studies. Our aim was to find a simple EV-enrichment method for reliable quantification of EVs in plasma to be used as biomarker of disease. Plasma of ten healthy subjects was processed using sedimentation rate- (sucrose cushion ultracentrifugation—sUC) and size- (size exclusion chromatography—SEC) based methods. According to nanoparticle tracking analysis (NTA), asymmetrical flow field-flow fractionation coupled to detectors (AF4-UV-MALS), miRNA quantification, transmission electron microscopy and enzyme-linked immunosorbent assay, enrichment of EVs from plasma with sUC method lead to high purity of EVs in the samples. High nanoparticle concentrations after SEC resulted from substantial contamination with lipoproteins and other aggregates of EV-like sizes that importantly affect downstream EV quantification. Additionally, sUC EV-enrichment method linked to quantification with NTA or AF4-UV-MALS is repeatable, as the relative standard deviation of EV size measured in independently processed samples from the same plasma source was 5.4% and 2.1% when analyzed by NTA or AF4-UV-MALS, respectively. In conclusion, the sUC EV-enrichment method is compatible with reliable measurement of concentration and size of EVs from plasma and should in the future be tested on larger cohorts in relation to different diseases. This is one of the first studies using AF4-UV-MALS to quantify EVs in blood plasma, which opens new possible clinical utility for the technique.

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“…Diabetes is a multifactorial disorder having a wide range of lipid abnormalities. In type 2 diabetes mellitus, there is an increased incidence of hypertriglyceridemia as compared to other lipid abnormalities [ 16 - 17 ]. This study evaluated the correlation between glycated hemoglobin (HbA1c) and triglycerides level and the results showed that there is a significant correlation between high HbA1c and high triglyceride.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Glycated Hemoglobin and Triglyceride Level in Type 2 Diabetes Mellitus

Naqvi

Naveed

Ali

et al. 2017

Cureus

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ContextDyslipidemia is quite prevalent in non-insulin dependent diabetes mellitus. Maintaining tight glycemic along with lipid control plays an essential role in preventing micro- and macro-vascular complications associated with diabetes. PurposeThe main purpose of the study was to highlight the relationship between glycosylated hemoglobin (HbA1c) and triglyceride levels. This may in turn help in predicting the triglyceride status of type 2 diabetics and therefore identifying patients at increased risk from cardiovascular events. Hypertriglyceridemia is one of the common risk factors for coronary artery disease in type 2 diabetes mellitus (DM). Careful monitoring of the blood glucose level can be used to predict lipid status and can prevent most of the complications associated with the disease.MethodThis is a cross-sectional study using data collected from the outpatient diabetic clinic of Jinnah Postgraduate Medical Centre (JPMC) Karachi, Pakistan. Patients of age 18 years and above were recruited from the clinic. A total of consenting 509 patients of type 2 diabetes mellitus were enrolled over a period of 11 months. For statistical analysis, SPSS Statistics for Windows, Version 17.0 ( IBM Corp, Armonk, New York) was used and Chi-square and Pearson’s correlation coefficient was used to find the association between triglyceride and HbA1c. The HbA1c was dichotomized into four groups on the basis of cut-off. Chi-square was used for association between HbA1c with various cut-off values and high triglyceride levels. Odds-ratio and its 95% confidence interval were calculated to estimate the level of risk between high triglyceride levels and HbA1c groups. The p-value < 0.05 was considered statistically significant for all the tests applied for significance.ResultThe association of high triglyceride was evaluated in four different groups of HbA1c, with a cut-off seven, eight, nine and 10 respectively. With HbA1c cut-off value of 7%, 74% patients had high triglycerides and showed a significant association with high triglyceride levels at p < 0.001 and odds ratio was 2.038 (95% confidence interval: 1.397 – 2.972). Logistic regression models were adjusted for demographic factors (age, race, gender), lifestyle factors (smoking, body mass index, lifestyle) and health status factors (blood pressure, physician-rated health status).ConclusionAfter adjusting for relevant covariates, glycated hemoglobin was positively correlated with high triglyceride. Hence, HbA1c can be an indicator of triglyceride level and can be one of the predictors of cardiovascular risk factors in type 2 diabetes mellitus.

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Levels of Apolipoprotein A1, B100 and Lipoprotein (a) in Controlled and Uncontrolled Diabetic Patients and in Non-Diabetic Healthy People

Cited by 9 publications

References 32 publications

Hypertriglyceridemia and its association with Glycated Hemoglobin in Type 2 Diabetes Mellitus – A cross sectional study

Hypertriglyceridemia and its association with Glycated Hemoglobin in Type 2 Diabetes Mellitus – A cross sectional study

Enrichment of plasma extracellular vesicles for reliable quantification of their size and concentration for biomarker discovery

Correlation between Glycated Hemoglobin and Triglyceride Level in Type 2 Diabetes Mellitus

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