Levels of beta‐trace protein in optic disc pit with macular detachment

Abstract

BackgroundTo report beta‐trace protein (β TP) levels in the subretinal fluid (SRF) of four patients with a macular detachment associated with optic disc pit (ODP).MethodsFour patients with a serous retinal detachment involving the macula was operated by pars plana vitrectomy (PPV) with C2F6 gas tamponade and peeling of internal limiting membrane (ILM). Patients with a follow‐up period exceeding one year postoperatively were included in the study. The SRF was drained using a fine cannula without laser photocoagulation, and the samples were analysed using particle‐enhancing nephelometry. The levels of β TP were compared to 20 routine cerebrospinal fluid (CSF) samples.ResultsIn four of the five samples from SRF had relatively low β TP levels, with a mean concentration of 6.6 mg/l (range 2.0 to 23.1 mg/l) compared to 16.0 mg/l (range 6.3‐26.8 mg/l) in CSF. The only SRF sample within the range corresponding to normal CSF was the first sample from patient 4, and the analysis of the renewed aspirate during the second operation was 2.8 mg/l. Postoperatively, the regression of SRF was slow, but regression of SRF in the foveal region took place in all cases; however, visual acuity (VA) was improved in only half of the patients.ConclusionThe results from the analysed SRF regarding β TP concentration in these patients indicate that the SRF in ODP is not identical to CSF, as the concentrations of β TP differ.

A prospective long‐term follow‐up study of optic disc pit maculopathy treated with pars plana vitrectomy, drainage of subretinal fluid and peeling of internal limiting membrane

“…The exact nature of the ODP is unknown, as is the origin of subretinal fluid. We have previously published data where the subretinal fluid was evaluated for Beta-trace protein, which is utilized to detect the presence of cerebrospinal fluid (Makdoumi et al 2017). These findings indicate that SRF in ODP-M does not have levels of the protein consistent with CSF and may support the hypothesis that the fluid originates as a result of vitreous traction associated with the optic disc anomaly.…”

Inner retinal fenestration for paediatric optic disc pit maculopathy: a case series

“…Some doubt this theory due to differences in hydrostatic pressure between the CSF and intraocular pressure, as well as the inability to displace the macular fluid back to the CSF [3]. Studies analysing the SRF aspirated at the time of surgery have conflicting results [8,9]. Histopathologic analysis of a canine optic disc pit model suggests that there may be a connection between the vitreous and macular fluid [4].…”