Levels of circulating microparticles in septic shock and sepsis-related complications: a case-control study

Boscolo, Annalisa; Campello, Elena; Bertini, D; Spiezia, Luca; Lucchetta, Vittorio; Piasentini, Eleonora; Radu, Claudia; Manesso, L.; Ori, Carlo; Simioni, Paolo

doi:10.23736/s0375-9393.18.12782-9

Cited by 28 publications

(31 citation statements)

References 35 publications

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“…In DIC patients, endothelial-derived CD105+-MPs are increased as well as leucocyte-derived CD11a+-MPs when platelet-derived GPIb+-MPs were very low, reflecting thrombocytopenia. 24 – 26 This finding may be related to patient selection, inclusion time, different sepsis stages, different detection methods, and unknown cellular modulation mechanism. There are many explanations for the decrease in circulating MP levels in sepsis DIC.…”

Section: Discussionmentioning

confidence: 99%

Preliminary study of microparticle coagulation properties in septic patients with disseminated intravascular coagulation

et al. 2021

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Background Sepsis typically results in enhanced coagulation system activation and microthrombus formation. Microparticle (MP) production promotes coagulation and enhances pro-coagulation. This study investigated how circulating MP levels and tissue factor-bearing MP (TF+-MP) activity caused coagulation in patients with septic disseminated intravascular coagulation (DIC). Methods Thirty patients with septic DIC and 30 healthy controls were studied from December 2017 to March 2019. Patient blood samples were collected at enrolment (day 1) and on days 3 and 5; DIC scores and Sequential Organ Failure Assessment (SOFA) scores were recorded. TF+-MP activity was measured using TF-dependent factor Xa generation experiments. Circulating MP concentrations were determined by MP capture assay. Clotting factor activity, antithrombin level, soluble thrombomodulin, and serum tissue factor pathway inhibitor (TFPI) concentrations were measured. Results Patients with septic DIC had lower circulating MP levels than healthy control patients. Circulating MP levels in patients with septic DIC were positively correlated with DIC scores and negatively correlated with coagulation factors, but TF+-MP activity did not correlate with clotting factor levels and TFPI. Conclusions In patients with septic DIC, circulating MP levels are important in promoting coagulation activation and increasing clotting factor consumption. TF+-MP activity may not be the main form of active TF.

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Section: Discussionmentioning

confidence: 99%

Preliminary study of microparticle coagulation properties in septic patients with disseminated intravascular coagulation

et al. 2021

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“…Microparticles (MPs), cell membrane-derived particles, play a critical role in both the initiation and development of sepsis. There are a number of studies describing the presence of the endothelial-derived MPs, [28][29][30] platelet-derived MPs, 29,31,32 or leukocyte-derived MPs 29,33 in cohorts of patients with sepsis or septic 1118 when compared with the healthy controls; their concentrations in the septic shock patients were even significantly higher than those in the sepsis patients. During the early stage of sepsis, from day 1 to day 5 after ICU admission, levels of NDMPs continuously increased as the sepsis developed, suggesting that neutrophils were activated by microbes and, in turn, produced abundant NDMPs.…”

Section: Discussionmentioning

confidence: 99%

<p>Circulating Neutrophil-Derived Microparticles Associated with the Prognosis of Patients with Sepsis</p>

Chen

Wang

Pan

et al. 2020

JIR

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Introduction Because of its high morbidity and mortality, sepsis remains the leading cause of death in the ICU. Microparticles (MP) have been largely studied as potential diagnostic or prognostic markers in various diseases including sepsis. Objective The biological and clinical relevance of neutrophil-derived microparticles (NDMPs) within the MP population remains unclear. The objective of this study was to elucidate the relationship between plasma NDMPs and the prognosis of patients with sepsis and/or septic shock. Methods The study was designed as an observational, noninterventional clinical study. The cohort for this study included 40 sepsis and 40 septic shock patients together with 10 healthy controls admitted to the Intensive Care Unit (ICU) and the Health Surveillance Center in the Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, China, from January to November 2018, respectively. The degree of critical disease for sepsis and septic shock was evaluated, with data analyses conducted from 2018 to 2019. Results On days 1, 3 and 5 post-admission a series of data including plasma NDMP levels, patient demographics, TNF-α levels, IL-6 levels, sTREM-1 levels, and the sepsis severity score measurements were collected. A survival curve was plotted against levels of plasma NDMPs. Levels of NDMPs were observed to be higher in the septic shock patients than in the sepsis patients on days 1, 3, and 5 post-ICU admission ( p < 0.05). NDMP levels were significantly increased in sepsis and septic shock patients with a parallel increase in pro-inflammatory mediators and sepsis severity score ( p < 0.05) as well as mortality. Conclusion Our data suggest that NDMPs may be a biomarker of sepsis severity and mortality although its implications on sepsis prognosis warrant further study.

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“…The cohort of patients reported in the present study has been partially described in previous studies [15,16].…”

Section: Methodsmentioning

confidence: 99%

Whole-blood hypocoagulable profile correlates with a greater risk of death within 28 days in patients with severe sepsis

Boscolo

Spiezia

Campello

et al. 2020

Korean J Anesthesiol

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Despite continually updated sepsis/septic shock guidelines and bundles [1] recommending early diagnosis and prompt initiation of therapy, sepsis remains a challenge worldwide. The overall mortality rate of septic shock ranges from 25-30%, reaching 40-60% among hospitalized patients [1][2][3][4][5]. Sepsis is a complex systemic defense mechanism to an overwhelming infection. The inflammatory response against an invading pathogen is the result of several hemostatic alterations, notably the dysregulation of pro-and anti-coagulant factors [6][7][8][9]. Although hypocoagulability appears to accurately predict a fatal outcome in sepsis, conventional coagulation tests are unable to reliably detect sep-

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Levels of circulating microparticles in septic shock and sepsis-related complications: a case-control study

Cited by 28 publications

References 35 publications

Preliminary study of microparticle coagulation properties in septic patients with disseminated intravascular coagulation

Preliminary study of microparticle coagulation properties in septic patients with disseminated intravascular coagulation

<p>Circulating Neutrophil-Derived Microparticles Associated with the Prognosis of Patients with Sepsis</p>

Whole-blood hypocoagulable profile correlates with a greater risk of death within 28 days in patients with severe sepsis

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