Levels of estradiol and testosterone are altered in Chinese men with sexual dysfunction

Wu, Feng; Chen, T.; Mao, Shanhua; Jiang, Hui; Ding, Qiang; Xu, Gang

doi:10.1111/andr.12195

Cited by 28 publications

(36 citation statements)

References 35 publications

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“…Wu et al . () found that patients with PE had higher levels of testosterone when compared with controls. Our study suggests that patients with LPE have had higher prenatal androgens exposure than controls.…”

Section: Discussionmentioning

confidence: 99%

The relationship between anogenital distance and lifelong premature ejaculation

et al. 2019

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Background Many diseases have been associated with anogenital distance, as an indicator of intrauterine androgen exposure. Objectives The aim of this study was to investigate the association between lifelong premature ejaculation and anogenital distance. Materials and methods The study included 140 participants: 70 with lifelong premature ejaculation (group 1) and 70 without any ejaculatory complaints (group 2). Premature Ejaculation Diagnostic Tool and stopwatch intravaginal ejaculatory latency time were recorded from all participants in order to evaluate ejaculatory function. Two variants of anogenital distance were measured: anogenital distance (from anus to the posterior base of the scrotum) from anus to the posterior base of the scrotum and anogenital distance (from anus to the cephalad insertion of the penis) to the cephalad insertion of the penis. We compared differences between groups and correlations between anogenital distance variants and patients’ characteristics. Results The groups were similar in terms of age, BMI, and total testosterone levels. The mean anogenital distance (from anus to the posterior base of the scrotum) scores were 59.45 ± 10.76 vs. 55.02 ± 10.13 (p = 0.01), and anogenital distance (from anus to the cephalad insertion of the penis) scores were 128.37 ± 22.2 vs. 126.78 ± 16.21 (p = 0.63) in groups 1 and 2, respectively. Significant correlation was observed between anogenital distance (from anus to the posterior base of the scrotum) and Premature Ejaculation Diagnostic Tool scores (r = 0.199, p = 0.019) and intravaginal ejaculatory latency time (r = −0.185, p = 0.028). There were no statistically significant differences between anogenital distance (from anus to the posterior base of the scrotum) scores and total testosterone levels and between anogenital distance (from anus to the cephalad insertion of the penis) and Premature Ejaculation Diagnostic Tool scores or intravaginal ejaculatory latency time. Conclusions These results suggest that longer anogenital distance is associated with higher possibility of lifelong premature ejaculation. However, further studies are needed to confirm our results.

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Section: Discussionmentioning

confidence: 99%

The relationship between anogenital distance and lifelong premature ejaculation

et al. 2019

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“…On the other hand, T acts on a peripheral level by controlling the function and expression of nitric oxide synthase and phosphodiesterase type-5 (PDE5) which regulate the ejaculatory process by acting on the contractility of the male genital tract, as vas deferens (Mancina et al, 2005). However, reduced estradiol/T ratio results in a decrease in the ejaculatory latency time via accumulating of parasympathetic excitation which induces the expulsion phase (Wu et al, 2016). In a retrospective case-control study, Wu et al investigated the relationship between sexual dysfunction and the levels and ratios of estradiol to T in 531 Chinese male patients with complaints of PE or ED, as well as 347 healthy controls.…”

Section: Discussionmentioning

confidence: 99%

“…However, increasing evidence suggest that T is involved in the regulation of ejaculatory reflex (Corona et al, 2008;Wu et al, 2016). Testosterone (T) is the key hormone of male sexuality, such as gender identity, sexual desire, and erection.…”

Section: Introductionmentioning

confidence: 99%

“…Testosterone (T) is the key hormone of male sexuality, such as gender identity, sexual desire, and erection. Furthermore, recently it was suggested that elevated T and reduced estradiol enhance the parasympathetic excitation, and as a consequence, ejaculatory latency time will be shortened (Wu et al, 2016). Androgens influence ejaculatory reflex by several mechanisms: (i) acting on the various central and peripheral nucleuses which are related to the ejaculatory pathways, (ii) altering the expression of several mediators which mediate the ejaculatory reflex, (iii) regulating the different pathways which are associated with the contractility of male genital tract (Corona et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Androgens influence ejaculatory reflex by several mechanisms: (i) acting on the various central and peripheral nucleuses which are related to the ejaculatory pathways, (ii) altering the expression of several mediators which mediate the ejaculatory reflex, (iii) regulating the different pathways which are associated with the contractility of male genital tract (Corona et al, 2012). Furthermore, recently it was suggested that elevated T and reduced estradiol enhance the parasympathetic excitation, and as a consequence, ejaculatory latency time will be shortened (Wu et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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The relationship between the second‐to‐fourth digit ratios and lifelong premature ejaculation: a prospective, comparative study

et al. 2017

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To investigate the relationship between the fetal androgen exposure and lifelong premature ejaculation by using the ratio of the second (index)-to-fourth (ring) digits (2D : 4D) which is the marker for higher prenatal androgen exposure. Totally 65 patients with lifelong premature ejaculation and 65 control cases without any ejaculatory complaints were enrolled in the study. A detailed medical history was obtained and self-estimated intravaginal ejaculatory latency times were recorded. Ejaculation function was evaluated by Premature Ejaculation Diagnostic Tool. The lengths of the second and fourth digits of both hands were measured and 2D : 4Ds were calculated. The mean 2D : 4D values were 0.964 ± 0.024 vs. 0.978 ± 0.032 (p = 0.004) for the right hand and 0.966 ± 0.023 vs. 0.979 ± 0.032 (p = 0.006) for the left hand in lifelong premature ejaculation and control groups, respectively. Significant correlations were observed between the digit ratios and self-estimated intravaginal ejaculatory latency time (r = 0.258, p = 0.003 for right hand; r = 0.240, p = 0.06 for left hand), and between the digit ratios and total Premature Ejaculation Diagnostic Tool scores (r = -0.263, p = 0.003 for right hand; r = -0.238, p = 0.06 for left hand). Individuals with lower digit ratios have higher risks of shorter intravaginal ejaculatory latency times. These results suggest that increased fetal androgen exposure may be a new risk factor for the development of lifelong premature ejaculation.

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