Levels of malondialdehyde in the gastric juice: Its association with <i>Helicobacter pylori</i> infection and stomach diseases

Wang, Yao‐Kuang; Chiang, Wei‐Chih; Kuo, Fu‐Chen; Wu, Meng‐Chieh; Shih, Hsiang‐Yao; Wang, Sophie S.W.; Liu, Chung‐Jung; Chen, Yen‐Hsu; Wu, Deng‐Chyang; Su, Wei‐Wen; Huang, Yeou‐Lih

doi:10.1111/hel.12460

Cited by 19 publications

(12 citation statements)

References 30 publications

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“…Uncontrolled high concentrations of ROS and reactive nitrogen species cause the formation of free radical-mediated chain reactions resulting in direct and indirect damages to proteins, nucleic acids, and lipids, followed by activation of the apoptotic pathway and the development of cancer, arteriosclerosis, aging, neurodegenerative diseases, and diabetes (Haigis and Yankner, 2010; Paravicini and Touyz, 2006; Shukla et al, 2011; Trachootham et al, 2009). Malondialdehyde (MDA) is the most mutagenic compound produced during lipid peroxidation and increases during exposure to heat stress in the mitochondria and plasma (Wang et al, 2018). In addition, abnormal increases in body temperature increase the level of nitric oxide (NO) synthase and stimulate the release of NO (Chen et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

The effect of heat stress on hematological parameters and oxidative stress among bakery workers

et al. 2020

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Heat stress causes physiological changes, and changes in hematological parameters and hormonal levels in the human body, known as thermal strain. This study was conducted to determine the effect of exposure to heat stress on hematological parameters and oxidative stress in the bakers of Shahroud City, Iran. A total of 163 bakery workers (exposed group) and 135 office workers (unexposed group) with a minimum of 1-year working experience were selected. Exposure to heat stress was measured using ISO-7243 criteria on the hottest days of the year (late July and August). Wet-bulb globe temperature (WBGT) was calculated based on indoor environments. Oxidative stress indices including malondialdehyde (MDA), nitric oxide (NO), total antioxidant capacity (TAC) in the bakers' and office workers’ serum and hematological parameters were measured. Statistical analysis was done through independent t-test, and multivariate linear regression using SPSS v24. Analysis of hematological parameters showed that about 70% and 68% of the bakers had abnormal mean cell volume (MCV) and white blood cell (WBC) count, respectively, while only around 12% of them had abnormal mean cell hemoglobin concentration (MCHC). The counts of red blood cells (RBC), WBC, lymphocytes (LYM), and MCV showed significant differences in different occupational groups ( p < 0.05). The levels of MDA and NO were significantly higher in bakers with WBGT more than the threshold value ( p < 0.05). The WBGT index for assessing heat stress can be used as a predictor variable for MDA and NO levels. In addition, heat stress exposure could be a risk factor for abnormal WBC, RBC, LYM, and MCV.

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Section: Introductionmentioning

confidence: 99%

The effect of heat stress on hematological parameters and oxidative stress among bakery workers

et al. 2020

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“…In contrast, the SOD activity of the nanoformulation group under a magnetic field was lower than that of the free PTX group, because the magnetic field increased the targeting effect of the nanoformulation. MDA, an indicator of the degree of cell membrane damage, could reflect the degree of lipid oxidation (Wang et al., 2018 ). As shown in Figure 9(B2) , compared to the control group, the level of MDA in the Fe 3 O 4 group and Fe 3 O 4 @mSiO 2 -NH 2 -FA group showed no significant difference, indicating that Fe 3 O 4 and Fe 3 O 4 @mSiO 2 -NH 2 -FA did not cause cell damage.…”

Section: Resultsmentioning

confidence: 99%

Effect and mechanism of paclitaxel loaded on magnetic Fe ₃ O ₄ @mSiO ₂ -NH ₂ -FA nanocomposites to MCF-7 cells

Deng

Yin

et al. 2022

Drug Delivery

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Magnetic Fe 3 O 4 nanoparticles were prepared via a simple hydrothermal method and utilized to load paclitaxel. The average particle size of Fe 3 O 4 nanoparticles was found to be 20.2 ± 3.0 nm, and the calculated saturation magnetization reached 129.38 emu/g, verifying superparamagnetism of nanomaterials. The specific surface area and pore volume were 84.756 m 2 /g and 0.265 cm 3 /g, respectively. Subsequently, Fe 3 O 4 @mSiO 2 nanoparticles were successfully fabricated using the Fe 3 O 4 nanoparticles as precursors with an average size of 27.81 nm. The relevant saturation magnetization, zeta potential, and specific surface area of Fe 3 O 4 @mSiO 2 -NH 2 -FA were respectively 76.3 emu/g, −14.1 mV, and 324.410 m 2 /g. The pore volume and average adsorption pore size were 0.369 cm 3 /g and 4.548 nm, respectively. Compared to free paclitaxel, the solubility and stability of nanoparticles loaded with paclitaxel were improved. The drug loading efficiency and drug load of the nanoformulation were 44.26 and 11.38%, respectively. The Fe 3 O 4 @mSiO 2 -NH 2 -FA nanocomposites were easy to construct with excellent active targeting performance, pH sensitivity, and sustained-release effect. The nanoformulation also showed good biocompatibility, where the cell viability remained at 73.8% when the concentration reached 1200 μg/mL. The nanoformulation induced cell death through apoptosis, as confirmed by AO/EB staining and flow cytometry. Western blotting results suggested that the nanoformulation could induce iron death by inhibiting Glutathione Peroxidase 4 (GPX4) activity or decreasing Ferritin Heavy Chain 1 (FTH1) expression. Subsequently, the expression of HIF-1α was upregulated owing to the accumulation of reactive oxygen species (ROS), thus affecting the expression of apoptosis-related proteins regulated by p53, inducing cell apoptosis.

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“…The LPO levels and antioxidant status were also measured in patients with oral and oropharyngeal cancer, where the increase in MDA levels and the decrease in the amount of antioxidants in blood plasma were detected [ 53 ]. Interestingly, both an increase [ 54 , 55 ] and a decrease in MDA levels [ 56 ] have been shown in patients with gastric cancer.…”

Section: Role Of Oxidative Stress In Cancer Progressionmentioning

confidence: 99%

Therapeutic Influence on Important Targets Associated with Chronic Inflammation and Oxidative Stress in Cancer Treatment

Neganova

Liu

Aleksandrova

et al. 2021

Cancers

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Chronic inflammation and oxidative stress are the interconnected pathological processes, which lead to cancer initiation and progression. The growing level of oxidative and inflammatory damage was shown to increase cancer severity and contribute to tumor spread. The overproduction of reactive oxygen species (ROS), which is associated with the reduced capacity of the endogenous cell defense mechanisms and/or metabolic imbalance, is the main contributor to oxidative stress. An abnormal level of ROS was defined as a predisposing factor for the cell transformation that could trigger pro-oncogenic signaling pathways, induce changes in gene expression, and facilitate accumulation of mutations, DNA damage, and genomic instability. Additionally, the activation of transcription factors caused by a prolonged oxidative stress, including NF-κB, p53, HIF1α, etc., leads to the expression of several genes responsible for inflammation. The resulting hyperactivation of inflammatory mediators, including TNFα, TGF-β, interleukins, and prostaglandins can contribute to the development of neoplasia. Pro-inflammatory cytokines were shown to trigger adaptive reactions and the acquisition of resistance by tumor cells to apoptosis, while promoting proliferation, invasion, and angiogenesis. Moreover, the chronic inflammatory response leads to the excessive production of free radicals, which further aggravate the initiated reactions. This review summarizes the recent data and progress in the discovery of mechanisms that associate oxidative stress and chronic inflammation with cancer onset and metastasis. In addition, the review provides insights for the development of therapeutic approaches and the discovery of natural substances that will be able to simultaneously inhibit several key oncological and inflammation-related targets.

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Levels of malondialdehyde in the gastric juice: Its association with Helicobacter pylori infection and stomach diseases

Abstract: Malondialdehyde in gastric juice could be used as a potential diagnostic biomarker for H. pylori infection and associated gastric diseases. The gastric juice MDA levels increased proportionally with the severity of gastric diseases.

Cited by 19 publications

References 30 publications

The effect of heat stress on hematological parameters and oxidative stress among bakery workers

The effect of heat stress on hematological parameters and oxidative stress among bakery workers

Effect and mechanism of paclitaxel loaded on magnetic Fe ₃ O ₄ @mSiO ₂ -NH ₂ -FA nanocomposites to MCF-7 cells

Therapeutic Influence on Important Targets Associated with Chronic Inflammation and Oxidative Stress in Cancer Treatment

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Levels of malondialdehyde in the gastric juice: Its association with Helicobacter pylori infection and stomach diseases

Abstract: Malondialdehyde in gastric juice could be used as a potential diagnostic biomarker for H. pylori infection and associated gastric diseases. The gastric juice MDA levels increased proportionally with the severity of gastric diseases.

Cited by 19 publications

References 30 publications

The effect of heat stress on hematological parameters and oxidative stress among bakery workers

The effect of heat stress on hematological parameters and oxidative stress among bakery workers

Effect and mechanism of paclitaxel loaded on magnetic Fe 3 O 4 @mSiO 2 -NH 2 -FA nanocomposites to MCF-7 cells

Therapeutic Influence on Important Targets Associated with Chronic Inflammation and Oxidative Stress in Cancer Treatment

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Product

Resources

About

Effect and mechanism of paclitaxel loaded on magnetic Fe ₃ O ₄ @mSiO ₂ -NH ₂ -FA nanocomposites to MCF-7 cells