Levels of mRNA for three selenoproteins in skeletal muscle of fetal and newborn pigs

Terry, Emily N.; Michal, Jennifer J.; Hostetler, Chris E.; Kincaid, R.L.

doi:10.1016/j.livsci.2008.12.005

Cited by 10 publications

(5 citation statements)

References 20 publications

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“…The SelW mRNA levels in rodents [27][28][29], primates [30,31], and pigs [32,33] are generally sensitive to Se status. In this study, the results of feeding three levels of dietary Se for 55 days indicated that SelW gene expression in the chicken pancreas was sensitive to dietary Se content.…”

Section: Discussionmentioning

confidence: 99%

Dietary selenium influences pancreatic tissue levels of selenoprotein W in chickens

Wang

Sun

Zhang

et al. 2011

Journal of Inorganic Biochemistry

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Section: Discussionmentioning

confidence: 99%

Dietary selenium influences pancreatic tissue levels of selenoprotein W in chickens

Wang

Sun

Zhang

et al. 2011

Journal of Inorganic Biochemistry

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“…In this study, we observed the mRNA expression of SelW in the gastrointestinal tract tissues of 90-day-old male chickens. The SelW mRNA levels in rodents (Vendeland et al 1995;Yeh et al 1995Yeh et al , 1997bYeh et al , 1998Sun et al 1998), primates (Gu et al 1999(Gu et al , 2000Bellingham et al 2003), pigs (Terry et al 2009;Zhou et al 2009) and sheep (Yeh et al 1997a;Sun et al 1999) are generally sensitive to Se status. The results of the present work confirm that SelW gene expression in the gastrointestinal tract of avian is also sensitive to dietary Se content, consistent with these earlier studies.…”

Section: Discussionmentioning

confidence: 99%

Selenoprotein W gene expression in the gastrointestinal tract of chicken is affected by dietary selenium

et al. 2010

Biometals

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Selenoprotein W (SelW) and selenium (Se) plays important roles in gastrointestinal function and that SelW expression in the gastrointestinal system of mammals is sensitive to Se levels. However, little is known about the pattern of SelW expression in the bird gastrointestinal tract. To investigate the distribution of SelW and effects of dietary Se levels on the SelW mRNA expression in the gastrointestinal tract tissues of birds, 1-day-old male chickens were fed either a commercial diet or a Se-supplemented diet containing 1.0, 2.0, 3.0 or 5.0 mg/kg sodium selenite for 90 days. The gastrointestinal tract tissues (tongue, esophagus, crop, proventriculus, gizzard, duodenum, small intestine, cecum and rectum) were collected and examined for Se content and mRNA levels of SelW. The mRNA expression of SelW was detected in all tissues. The greatest increase in SelW mRNA levels was observed in the gizzard, whereas Se content was highest in the duodenum and small intestine. A significant increase in SelW mRNA levels was observed in the gastrointestinal tract tissues of chickens fed the diets containing 1-3 mg/kg sodium selenite while decreased SelW mRNA levels were observed in the esophagus, crop, proventriculus, gizzard, duodenum and cecum in chickens fed the diet containing 5 mg/kg sodium selenite. These data indicate that SelW is widely expressed in the gastrointestinal tract tissues of birds and the transcription of the SelW gene is very sensitive to dietary Se.

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“…Selenium (Se) is a nutritionally essential trace element for humans and many other species [1]. Previous data have suggested that Se plays an important role in chemopreventive effects [2,3], muscle metabolism [4,5], oxidant defense [6], neurobiology [7], aging [8], and reproduction [9]. Many previous studies reported that Se also plays an important role in the immune system [10,11].…”

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Selenium Deficiency or Excess on Selenoprotein Gene Expression in the Spleen Tissue of Pigs

Wang

Teng

et al. 2019

Animals

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To evaluate the effects of dietary Se deficiency and excess on the mRNA levels of selenoproteins in pig spleen tissues, 20 healthy uncastrated boars (Duroc × Landrace × Yorkshire, 10 ± 0.72 kg) were randomly divided into four groups (5 pigs per group). The pigs were fed a Se deficient corn-soybean basal feed (Se content <0.03 mg/kg) or basal feed with added sodium selenite at 0.3, 1.0, or 3.0 mg Se/kg diet, respectively. The experiment lasted 16 weeks. The spleen tissue was collected to examine the mRNA expression levels of 24 selenoprotein genes at the end of the study. Compared with pigs in other groups, those fed with the 1.0 mg Se/kg diet had higher mRNA levels of glutathione peroxidase 1 (Gpx1), glutathione peroxidase 2 (Gpx2), deiodinase type II (Dio2), thioredoxin reductase 3 (Txnrd3), selenoprotein H (Selh), selenoprotein N, 1 (Sepn1), selenoprotein P1 (Sepp1), and selenoprotein V (Selv) in the spleen (p < 0.05). Dietary Se deficiency resulted in lower mRNA levels of Gpx1, Gpx2, glutathione peroxidase 3 (Gpx3), Dio2, thioredoxin reductase 2 (Txnrd2), Txnrd3, Selh, selenoprotein I (Seli), selenoprotein K (Selk), selenoprotein M (Selm), Sepn1, Sepp1, and Selv in the spleen than the other three groups. Dietary Se levels did not affect the mRNA levels of glutathione peroxidase 4 (Gpx4), deiodinase type I (Dio1), deiodinase type III (Dio3), selenophosphate synthetase 2 (Sephs2), thioredoxin reductase 1 (Txnrd1), selenoprotein O (Selo), selenoprotein S (Sels), selenoprotein W (Selw), selenoprotein X (Selx), and selenoprotein 15 (Sel15) in the spleen (p > 0.05). Dietary Se levels can affect the transcription levels of 14 selenoprotein genes in the spleen of pigs.

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Levels of mRNA for three selenoproteins in skeletal muscle of fetal and newborn pigs

Cited by 10 publications

References 20 publications

Dietary selenium influences pancreatic tissue levels of selenoprotein W in chickens

Dietary selenium influences pancreatic tissue levels of selenoprotein W in chickens

Selenoprotein W gene expression in the gastrointestinal tract of chicken is affected by dietary selenium

Effects of Dietary Selenium Deficiency or Excess on Selenoprotein Gene Expression in the Spleen Tissue of Pigs

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