Levels of organochlorine insecticides in milk of mothers from urban and rural areas of botucatu, SP, Brazil

Sant'Ana, Léa Silvia; Vassilieff, I.; Jokl, Lieselotte

doi:10.1007/bf01701635

Cited by 19 publications

(17 citation statements)

References 3 publications

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“…Although food intake is the main route of exposure, inhalator-y and dermal routes might have importance for mothers living in countries where sanitary actions are the main source of contamination. The concentration of DDT, which is the principal pollutant of breast milk in these areas, has caused concern about the health risk to breastfeed infants (Wolf 1983;Sant'Ana et al 1989). Attention must be drawn to the fact that in countries lacking strict bans on the sprayed applications of the organochlorine insecticides, residue levels of these chemicals may be present in human milk at considerably high levels.…”

mentioning

confidence: 99%

Organochlorine Pesticide Residues in Human Breast Milk from Tropical Areas in Mexico

Waliszewski

Sedas

Rivera

1996

Bulletin of Environmental Contamination and Toxicology

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mentioning

confidence: 99%

Organochlorine Pesticide Residues in Human Breast Milk from Tropical Areas in Mexico

Waliszewski

Sedas

Rivera

1996

Bulletin of Environmental Contamination and Toxicology

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“…In particular, we sought detailed information on the parental habitat (city or county) before and during the pregnancy. Despite the high pesticide impact in the Brazilian countryside, the EDC concentration seemed to be higher in urban areas as opposed to rural areas (Sant’Ana et al. , 1989; Smith, 1999).…”

Section: Methodsmentioning

confidence: 88%

“…In the state of Paraíba, a high percentage of its inhabitants lives in favelas , essentially shantytowns with no sewage system and/or near polluted rivers; insect proliferation is thus extremely difficult to control. The tropical climate and poor sanitary conditions, especially in urban zones, have resulted in the widespread and frequent use of residential DTT and other pesticides (Sant’Ana et al. , 1989; Smith, 1999; Montes et al.…”

Section: Introductionmentioning

confidence: 99%

High prevalence of micropenis in 2710 male newborns from an intensive‐use pesticide area of Northeastern Brazil

et al. 2012

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Exposure to endocrine-disrupting chemicals (EDCs) has been suggested to contribute to the increasing trends of external genital malformation in male newborns. In Northeastern Brazil, the poor sanitary conditions found in the favelas encourage the widespread use of pesticides. This 2-year study of a total birth cohort of full-term male newborns in the regional hospitals of Campina Grande (Paraíba, Brazil) sought to (1) accurately establish for the first time the incidences of neonatal male genital malformations, (2) investigate the endocrine and genetic aetiologies of these malformations, and (3) evaluate their associations with possible prenatal exposure to EDCs. A total of 2710 male newborns were explored for cryptorchidism, hypospadias and micropenis. Cases were referred to the Pediatric Endocrine Clinic for endocrine and genetic investigations, and all parents were interviewed about their environmental/occupational exposure to EDCs before/during pregnancy by paediatric endocrinologists using a detailed questionnaire. We observed 56 cases of genital malformation (2.07%), including 23 cryptorchidism (0.85%), 15 hypospadias (0.55%), and 18 micropenis (0.66%). All cases exhibited normal/subnormal testosterone production and none presented androgen receptor or 5α-reductase gene mutation. More than 92% of these newborns presented foetal contamination by EDCs, as their mothers reported daily domestic use of pesticides (i.e., DDT) and other EDCs. Most of these undervirilized male newborns presented additional EDC contamination, as 80.36% of the mothers and 58.63% of the fathers reported paid or unpaid work that entailed the use of pesticides and other EDCs before/during pregnancy for the mothers and around the time of fertilization for the fathers. The high rate of micropenis in our population associated with an elevated percentage of parental environmental/occupational exposure to EDCs before/during pregnancy indicates that foetal contamination may be a risk factor for the development of male external genital malformation.

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“…Os valores das STP nas amostras de leite materno no Brasil variaram para DDT de 1-2200 μg/L, para HCH de 2-270 μg/L, para HCB de 1-89 μg/L e para o Dieldrin de 1-10 μg/L [64][65][66][67][68][69][70][71][72][73] . As amostras de cabelo foram avaliadas para metilmercúrio e apresentaram concentrações variando entre 24 a 38000 μg/kg.…”

Section: Seres Humanosunclassified

Substâncias tóxicas persistentes (STP) no Brasil

Almeida¹,

Centeno²,

Bisinoti³

et al. 2007

Quím. Nova

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Levels of organochlorine insecticides in milk of mothers from urban and rural areas of botucatu, SP, Brazil

Cited by 19 publications

References 3 publications

Organochlorine Pesticide Residues in Human Breast Milk from Tropical Areas in Mexico

Organochlorine Pesticide Residues in Human Breast Milk from Tropical Areas in Mexico

High prevalence of micropenis in 2710 male newborns from an intensive‐use pesticide area of Northeastern Brazil

Substâncias tóxicas persistentes (STP) no Brasil

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