Levels of Oxidized LDL, Estrogens, and Progesterone in Placenta Tissues and Serum Paraoxonase Activity in Preeclampsia

Açıkgöz, Şerefden; Bayar, Ülkü; Çan, Murat; Güven, Berrak; Mungan, Görkem; Dogan, Suat Serhan Altıntepe; Sümbüloğlu, Vildan

doi:10.1155/2013/862982

Cited by 35 publications

(19 citation statements)

References 22 publications

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“…The results obtained by us are in agreement with an early study by Açikgöz et al, where they found decreased PON1 activity in pre-eclampsic mothers with FGR, whereas in preeclampsic mothers with normal babies, the level increased significantly [26]. Also, no changes in PON1 activity have been observed in mothers with preterm delivery in an early report involving Korean females [27].…”

Section: Discussionsupporting

confidence: 92%

Idiopathic Fetal Growth Restriction: Repercussion of Modulation in Oxidative Stress

et al. 2015

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Oxidative stress has been proposed as one of the causes involved in idiopathic fetal growth restriction (IFGR). However, the exact relationship between oxidative stress and IFGR is not understood. This study aimed at understanding the role of oxidative stress and antioxidant status in IFGR materno-fetal dyads and matched controls. 75 materno-fetal dyads with IFGR were enrolled with equal number of normal low risk controls. Malondialdehyde (MDA) levels were measured as marker of oxidative stress, while paraoxonase-1 (PON1) activity and total antioxidant capacity (TAC) of serum were measured as markers of antioxidant status. MDA levels were increased in both maternal and cord blood of IFGR neonates as compared to controls (p \ 0.001). TAC of serum were found to be decreased in IFGR (both maternal and cord blood) as compared to controls (p \ 0.001; p \ 0.05, respectively). PON1 activity was found to be decreased in the IFGR mothers while it was found increased in IFGR cord blood (p \ 0.01; p \ 0.001)). IFGR is a state of increased oxidative stress. Decreased PON1 enzymatic activity in mothers is also associated with IFGR.

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Section: Discussionsupporting

confidence: 92%

Idiopathic Fetal Growth Restriction: Repercussion of Modulation in Oxidative Stress

et al. 2015

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“…These hormones potentially exist in placental tissue at considerably higher concentrations than in maternal blood (15). Notably, estrogen concentrations are significantly lower in placental tissue from pregnancies complicated by preeclampsia (16), and this evidence supports the hypothesis that estrogen serves an important role in the development of preeclampsia (17). It is well known that estrogen stimulates expression of vascular endothelial growth factor (VEGF) and angiogenesis in the uterus during the normal reproductive cycle (18).…”

Section: The Expression and Activation Of Sex Steroid Receptors In Thsupporting

confidence: 74%

The expression and activation of sex steroid receptors in the preeclamptic placenta

Park

Lee

et al. 2018

Int J Mol Med

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Estrogen and progesterone are the main pregnancy hormones produced by the placenta. It is well understood that estrogen stimulates angiogenesis in the uterus during the reproductive cycle. Although the estrogen and progesterone signaling pathways are assumed to be associated with placental vascularization and preeclampsia, expression of estrogen receptors (ESRs) and progesterone receptor (PGR) in the placenta have not been well studied. The present study examined the expression patterns of steroid hormone receptors in placentas. Human placenta samples were collected and divided into normal and preeclampsia groups. Results revealed that expression levels of ESR1 were reduced, whereas ESR2 and PGR were elevated in preeclamptic placentas. To generate an in vitro preeclampsia environment, human placenta‑derived BeWo cells were incubated under hypoxic conditions, or treated with catechol‑O‑methyl transferase inhibitor (COMT‑in) or L‑NG‑nitroarginine methyl ester (L‑NAME). Expression levels of ESR1, ESR2 and PGR in hypoxic cells demonstrated similar regulation as those in placentas from women with preeclampsia. Although COMT‑in and L‑NAME did not significantly regulate the expression levels of the receptors, COMT‑in translocated ESR2 and PGR from the nucleus to the cytoplasm, indicating that these receptors were inactivated. These results suggested that ESRs and PGR are associated with symptoms of preeclampsia in the placenta. The expression of ESR1 was reduced in preeclamptic placenta and hypoxic BeWo cells. In addition, the activation of ESR2 and PGR was blocked in placenta cells subjected to COMT‑in treatment. The reduced ESR1 expression and inactivation of ESR2 and PGR proteins may affect the physiological complications of preeclampsia in the placenta.

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“…We found significantly increased levels of PON and arylesterase and a positive correlation between both antioxidant enzymes with adverse perinatal outcomes in severe preeclampsia. Similarly, Acıkgoz et al, reported increased PON activity in preeclampsia [32]. Furthermore, Altunhan et al, found increased PON activity in cord blood of the newborns born to preeclamptic mothers and suggested that increased cord blood TAS and PON levels indicate that the fetus is protected against oxidative damage [30].…”

Section: Discussionmentioning

confidence: 95%

Oxidative stress markers in severe preeclampsia and preeclampsia-related perinatal morbidity — preliminary report

Öztaş

Özler²,

Tokmak³

et al. 2016

Ginekol Pol

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Objectives: The aim of the study was to determine maternal serum total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase (PON) and arylesterase levels in severe preeclamptic pregnants and also to investigate whether these parameters are implicated in the occurence of perinatal morbidity or not. Material and methods:A case-control study was carried out including 60 pregnant women (30 with severe preeclampsia and 30 healthy controls). The optimal cut off points of oxidative stress markers for the diagnosis of severe preeclampsia and for the prediction of adverse perinatal outcomes were evaluated by receiver operating characteristic (ROC) analyses. Multivariate logistic regression analysis was used to determine if a relationship between adverse perinatal outcomes and serum oxidative stress markers was present or not.Results: TAS (OR = 37.486, 95% CI 3.535-397.519, p = 0.003), TOS (OR = 15.588, 95% CI 2.135-113.818, p = 0.007) and arylesterase (OR = 31.356, 95% CI 2.284-430.548, p = 0.01) were found to be diagnostic for preeclampsia. Statistically significant positive correlation of adverse perinatal outcomes with serum TAS, PON and arylesterase levels were determined. Besides, a significant negative correlation was found between serum TAS levels and gestational week (r = -0.342, p = 0.007) and also between serum PON levels and birthweight (r = -0.262, p = 0.043). Conclusions:Increased maternal serum TAS, TOS and arylesterase levels are significantly associated with the presence of severe preeclampsia. Furthermore, elevated maternal serum TAS, PON and arylesterase levels are significantly and positively correlated with adverse perinatal outcomes. We suggest that in preeclampsia increased oxidative status may cause adverse perinatal outcomes and antioxidants may be increased in order to protect the fetus against oxidative damage.

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Levels of Oxidized LDL, Estrogens, and Progesterone in Placenta Tissues and Serum Paraoxonase Activity in Preeclampsia

Cited by 35 publications

References 22 publications

Idiopathic Fetal Growth Restriction: Repercussion of Modulation in Oxidative Stress

Idiopathic Fetal Growth Restriction: Repercussion of Modulation in Oxidative Stress

The expression and activation of sex steroid receptors in the preeclamptic placenta

Oxidative stress markers in severe preeclampsia and preeclampsia-related perinatal morbidity — preliminary report

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