“…V. arctostaphylos has been widely used in Western Asia, the Caucasus, Siberia, North America, Southeastern Europe and different regions of Iran as a part of the heritage of the native herbal folk medicine. 22,23 The VA's properties which have been identified today are very extensive, including anti-cancer, blood lipid-lowering, reducing blood glucose, lowering blood pressure, anti-microbial, platelet anticoagulant, antihistamine, antioxidant properties. 24,25 Several chemical methods [26][27][28][29] such as high-performance liquid chromatography (HPLC), HPLC coupled with mass spectrometry (HPLC-MS), HPLC coupled to electrospray ionization-mass spectrometry (HPLC-EI-MS), Thin-layer chromatography (TLC), Gas-liquid chromatography (GLC), Ultraviolet-visible (UV-vis) and Nuclear magnetic resonance spectroscopy (NMRspectroscopy) have been utilized to analyses and detect of the VA in natural samples.…”