Levels of prostaglandin E₂ and Cysteinyl‐leukotrienes in sputum supernatant of patients with asthma: the effect of smoking

Abstract

The increased concentrations of PGE(2) and Cyst-LTs in sputum supernatants of smoking asthma are consistent with an up-regulation of these two mediators in this specific phenotype of asthma. Furthermore, Cyst-LTs are associated with eosinophilic inflammation, while PGE(2) is associated with the presence of neutrophilic inflammation in smoking asthma.

Vascular endothelial growth factor and cysteinyl leukotrienes in sputum supernatant of patients with asthma

“…This might be attributed mainly to the underlying asthma severity and the response to treatment. However published data supports that smoking significantly influences the concentration of Cyst-Lts in different biological fluids [28,29]. In an animal study, bronchial epithelial cells isolated from asthmatic rats reacted differently to chronic smoking exposure compared to cells from normal rats, leading to an increase of VEGF levels [30].…”

Role of Antileukotriene Drugs in Achievement of Bronchial Asthma Control

“…Заслуживает внимания участие цис-ЛТ в формировании воспаления у курящих больных БА. В исследовании К. Kontogianni et al [38] было показано, что в индуцированной мокроте курильщиков, страдающих астмой, уровень цис-ЛТ значимо выше, чем у некурящих пациентов, при этом он коррелировал с уровнем эозинофилов в индуцированной мокроте. У некурящих пациентов такой взаимосвязи отмечено не было.…”

Regulation of inflammation by lipid mediators in oral diseases

“…Lung fluids are an obvious target for analysis of LM involved in inflammatory lung diseases. Asthmatic patients had elevated sputum levels of Cys‐LTs and PGE 2 compared to healthy subjects (Papadaki et al , ), with smoking asthmatics exhibiting even higher sputum levels of these LM (Kontogianni et al , ). COPD patients, on the other hand, only exhibited elevated PGE 2 sputum levels, but no differences in Cys‐LT levels, compared to healthy controls (Drozdovszky et al , ).…”