Levels of serum IL‐1β, IL‐2, IL‐8 and tumor necrosis factor‐α in patients with unstable angina pectoris

Özeren, Ali; Aydın, Mustafa; Tokaç, Mehmet; Demircan, Nejat; Ünalacak, Murat; Gürel, Ahmet; Yazıcı, Mehmet

doi:10.1080/09629350310001633360

Cited by 47 publications

(40 citation statements)

References 24 publications

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“…TNF-alpha also upregulates membrane expression of vascular cell adhesion molecule-1 [56], which plays a well established role in atherosclerosis [57] and it precedes the development of thickened intima with foam cell lesions [58]. Apart from these in vitro observations, increased expression of serum TNF-alpha has been found in patients with atherosclerotic complications in population studies [59,60]. In RA patients, TNF-alpha enhances prothrombotic states such as dyslipidemia [61], but, most importantly, pooled evidence reveals that anti-TNF-alpha treatment may be in part responsible for reducing the risk for CVD events in RA [62].…”

Section: Inflammation and Atherosclerosismentioning

confidence: 97%

Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity

Metsios¹,

Kalinoglou²,

Sandoo³

et al. 2010

TOCMJ

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Inflammation disturbs biochemical pathways involved in homeostasis of the endothelium. Research has established clear links between inflammatory mediators, particularly C-reactive protein and tumour necrosis factor alpha, endothelial dysfunction, and atherosclerosis. Endothelial dysfunction and atherosclerosis may be subclinical at early stages, and thus the ability to detect them with non-invasive techniques is crucially important, particularly in populations at increased risk for cardiovascular disease, such as those with rheumatoid arthritis. This may allow the identification of interventions that may reverse these processes early on. One of the best non-pharmacological interventions that may achieve this is physical activity. This review explores the associations between inflammation, endothelial dysfunction, and atherosclerosis and discusses the role of exercise in blocking specific pathways in the inflammation, endothelial dysfunction -atherosclerosis network.

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Section: Inflammation and Atherosclerosismentioning

confidence: 97%

Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity

Metsios¹,

Kalinoglou²,

Sandoo³

et al. 2010

TOCMJ

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show abstract

“…High levels of IL-1 b, IL-8, and TNFa in patients with unstable angina pectoris suggested that these proinflammatory cytokines play an important role in the development of atherosclerosis and its complications (Ozeren et al, 2003). Studies of human myoblasts and isolated muscle tissue showed combinatorial effect of IL-1 b and IL-17 on the production of factors involved in inflammation (Chevrel et al, 2002).…”

Section: Discussionmentioning

confidence: 98%

“…Among genes downregulated at 1 day and 3 days posttransplantation in CsA 1 peptide treatment were proinflammatory cytokines such as Interleukin-1 beta (IL-1 b), the members of their receptor complexes (IL1r2, IL1nr), and cell adhesion molecules involved in the leukocyte adhesion cascade such as Selectin (Arstall et al, 1999;Batten et al, 1996;Bick et al, 1997;Chevrel et al, 2002;Finesterer, 2009;Ing et al, 1999;Kacimi et al, 1998;Li and Xiao, 2001;Libby et al, 1988;Libby, 1989, 1990;Loppnow et al, 1998;Long, 2001;Mountain et al, 2008;Muller-Werdan et al, 1998;Ono et al, 1998;Ozeren et al, 2003;Tomita et al, 2004;Ukimura et al, 2003;Westphal et al, 2008;Xia et al, 2006) (Table 2 and Fig. 2).…”

Section: Genes Downregulated In Csa 1 Peptide Treatmentmentioning

confidence: 97%

Intragraft gene expression profile associated with the induction of tolerance by allochimeric MHC I in the rat heart transplantation model

Lisik

Gong

Tejpal

et al. 2009

Genesis

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The MHC class I allochimeric protein containing donor-type epitopes on recipient-type heavy chains induces indefinite survival of heterotopic cardiac allografts in rats. We analyzed gene expression profile of heart allograft tissue. Mutated peptide [alpha1h1/u]-RT1.Aa that contains donor-type (Wistar Furth, WF; RT1u) immunogenic epitopes displayed on recipient-type (ACI, RT1a) was delivered into ACI recipients of WF hearts at the time of transplantation in addition to a 3 days course of oral cyclosporine. Microarray analysis was performed using Affymetrix Rat 230 2.0 Microarray. Allochimeric molecule treatment caused upregulation of genes involved in structural integrity of heart muscle, downregulation of IL-1beta a key modulator of the immune response, and downregulation of partitioning defective six homolog gamma PAR6, which is involved in T cell polarity, motility, and ability to scan dendritic cells (DC). These indicate that the immunosuppressive function of allochimeric molecule and/or the establishment of allograft tolerance depend on the induction of genes responsible for the heart tissue integrity, the suppression of cytokine pathway(s), and possibly the impairment of T cells mobility and their DC scanning ability. These novel findings may have important clinical implications for inhibition of chronic rejection in transplant recipients.

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“…was found in human atherosclerotic plaques [1,11]. The concentrations of MCP-1, IL-8, IL-2 receptor soluble α-subunit (sCD25), IL-6, IL-1β, and other proinfl ammatory markers are elevated in the blood of patients with unstable angina [2,8,13]. High levels of highly sensitive C-reactive protein (hsCRP) and MCP-1 are independent risk factors for repeated cardiovascular events in patients with a history of acute coronary syndrome (ACS) [5].…”

mentioning

confidence: 99%

Changes in the Concentration of Monocytic Chemotaxic Protein-1 in Patients with Unstable Angina Treated with Arixtra

et al. 2011

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The time course of inflammatory reaction markers in the blood of patients with unstable angina was studied during therapy including arixtra. Plasma concentration of monocytic chemotaxic protein-1 (MCP-1) decreased on days 2 and 3 in patients receiving arixtra and a trend to an increase in MCP-1 concentration was observed on day 7 after the drug was discontinued. After 1 month, MCP-1 level decreased in all patients. The concentration of highly sensitive C-reactive protein also decreased 1 month after the disease onset; no changes in the concentrations of IL-8 and IL-2 receptor α-subunit were detected during these periods. It seems that arixtra is characterized by an anti-inflammatory effect manifesting by reduction of plasma chemokine MCP-1 concentration.

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Levels of serum IL‐1β, IL‐2, IL‐8 and tumor necrosis factor‐α in patients with unstable angina pectoris

Abstract: We detected high levels of IL-1beta, IL-8 and TNF-alpha in patients with UAP during early phase. We suggest that proinflammatory cytokines (e.g. IL-1beta,IL-8, TNF-alpha) may play an important role in the development of atherosclerosis and its complications.

Cited by 47 publications

References 24 publications

Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity

Vascular Function and Inflammation in Rheumatoid Arthritis: the Role of Physical Activity

Intragraft gene expression profile associated with the induction of tolerance by allochimeric MHC I in the rat heart transplantation model

Changes in the Concentration of Monocytic Chemotaxic Protein-1 in Patients with Unstable Angina Treated with Arixtra

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