This paper presents a methodology for optimizing inertia driven dosing units, sometimes referred to as eductors, for use in small scale flow applications. The unit is assumed to operate at low to moderate Reynolds numbers and under steady state conditions. By applying topology optimization to the Brinkman penalized Navier-Stokes equation the design of the dosing units can be optimized with respect to dosing capability without initial design assumptions. The influence of flow resistance and speed is investigated to assess design performance under varying operating conditions.