Leveraging biomaterials for cancer immunotherapy: targeting pattern recognition receptors

Song, Wantong; Das, Mithun; Xu, Yuxing; Si, Xinghui; Zhang, Y.; Tang, Zhaohui; Chen, Xiaogang

doi:10.1016/j.mtnano.2019.100029

Cited by 33 publications

(18 citation statements)

References 168 publications

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“…Nanogels, innovative, and versatile carriers combining the advantages of nanoparticles and hydrogels have attracted considerable attention in drug delivery . Nanogels have nano‐sized aqueous crosslinked polymer networks and, like hydrogels, possess excellent biocompatibility and high loading capacities for therapeutics . For these distinctive advantages, nanogels have been applied widely for drug delivery, especially protein drugs which easily deactivate and break down.…”

Section: Introductionmentioning

confidence: 99%

Glucose and pH Dual‐Responsive Nanogels for Efficient Protein Delivery

Song

Yang

et al. 2019

Macromolecular Bioscience

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Direct delivery of protein suffers from their in vitro and in vivo instability, immunogenicity, and a relatively short half‐life within the body. To overcome these challenges, pH and glucose dual‐responsive biodegradable nanogels comprised of dextran and poly(L‐glutamic acid)‐g‐methoxy poly‐(ethylene glycol)/phenyl boronic acid (PLG‐g‐mPEG/PBA) are designed. The cross‐linked network imparted drug‐loading efficacy of α‐amylase up to 55.6% and hyaluronidase up to 29.1%. In vitro protein release profiles reveal that the release of protein is highly dependent on the pH or glucose concentrations, that is, less amount of protein is released at pH 7.4 or healthy blood glucose level (1 mg mL−1 glucose), while quicker release of protein occurs at pH 5.5 or diabetic blood glucose level (above 3 mg mL−1 glucose). Circular dichroism spectra show that the secondary structure of released protein is maintained compared to naive protein. Overall, the nanogels have provided a simple and effective strategy to deliver protein.

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Section: Introductionmentioning

confidence: 99%

Glucose and pH Dual‐Responsive Nanogels for Efficient Protein Delivery

Song

Yang

et al. 2019

Macromolecular Bioscience

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“…This strategy triggered IFN-α expression and tumor neoantigen-specific T cell response in three melanoma patients. [340] The PRR agonist can be delivered with tumor antigens by nanoplatform as nanovaccines, which achieved successful tumor inhibition in animal models. In addition, the process to identify and synthesize neoantigen peptides is time-consuming, and new technique and method are urgently needed to shorten this period of time.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…More recently, Song et al pointed out the importance of pattern recognition receptors (PRRs) expressed in innate immune cells and the potent ability of PRR agonists as adjuvants in activating innate immune system and instructing adaptive immune response . The PRR agonist can be delivered with tumor antigens by nanoplatform as nanovaccines, which achieved successful tumor inhibition in animal models.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Immunomodulatory Nanosystems

et al. 2019

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Immunotherapy has emerged as an effective strategy for the prevention and treatment of a variety of diseases, including cancer, infectious diseases, inflammatory diseases, and autoimmune diseases. Immunomodulatory nanosystems can readily improve the therapeutic effects and simultaneously overcome many obstacles facing the treatment method, such as inadequate immune stimulation, off‐target side effects, and bioactivity loss of immune agents during circulation. In recent years, researchers have continuously developed nanomaterials with new structures, properties, and functions. This Review provides the most recent advances of nanotechnology for immunostimulation and immunosuppression. In cancer immunotherapy, nanosystems play an essential role in immune cell activation and tumor microenvironment modulation, as well as combination with other antitumor approaches. In infectious diseases, many encouraging outcomes from using nanomaterial vaccines against viral and bacterial infections have been reported. In addition, nanoparticles also potentiate the effects of immunosuppressive immune cells for the treatment of inflammatory and autoimmune diseases. Finally, the challenges and prospects of applying nanotechnology to modulate immunotherapy are discussed.

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“…The application of engineered biomaterials to cancer immunotherapy has been reviewed elsewhere. 26 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 In this review, we focus on localized delivery of immunotherapy and the biomaterials—from hydrogels 52 to microneedles 53 , 54 —that enable this cancer treatment approach (Figure 1 ). It is hoped that this review will help interested nonexperts understand the latest developments, future prospects, and current challenges in the integration of engineered biomaterials and cancer immunotherapy, which may lead to new paradigms in cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

Engineered biomaterials for cancer immunotherapy

Cai

Yang

et al. 2020

MedComm

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Although cancer immunotherapy is showing tremendous promise and has progressed to the clinic, it has only achieved sporadic efficacy, with only a fraction of patients benefitting from the therapy and with undesirable side effects due to poor selectivity and high doses. Localized delivery of immunomodulators to activate anticancer immunity in situ avoids overactivation of the systemic immune system and reduces side effects. Engineered biomaterials—implantable, injectable, or transdermal—fabricated into drug delivery devices are critical components for the development of localized cancer immunotherapies. In this review, we briefly summarize progress in the application of engineered biomaterials to the localized delivery of cancer immunotherapy.

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Leveraging biomaterials for cancer immunotherapy: targeting pattern recognition receptors

Cited by 33 publications

References 168 publications

Glucose and pH Dual‐Responsive Nanogels for Efficient Protein Delivery

Glucose and pH Dual‐Responsive Nanogels for Efficient Protein Delivery

Immunomodulatory Nanosystems

Engineered biomaterials for cancer immunotherapy

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