Leveraging Potential of Nanotherapeutics in Management of Diabetic
                    Foot Ulcer

Pandey, Supriya; Shaif, Mohammad; Ansari, Tarique Mahmood; Shamim, Arshiya; Kushwaha, Poonam

doi:10.1055/a-1749-4909

Cited by 9 publications

(5 citation statements)

References 69 publications

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“…For example, nanomaterials, antibacterial surface coatings, phototherapy, and ultrasound reduce the risk of wound infection. 54 , 55 4. 3D printing technology: 3D printing technology can produce biological materials with complex structures and individual characteristics for wound repair.…”

Section: Discussionmentioning

confidence: 99%

Effect of Diabetes on Wound Healing: A Bibliometrics and Visual Analysis

Lang,

Li,

et al. 2024

JMDH

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Objective The quality of life of diabetic patients is seriously affected by wound healing difficulty, which can lead to increased infection, skin deep tissue injury and continuous pain. By analyzing the research trends and hot spots in this field, the visualization analysis map is constructed. Methods The contents of the selected articles were sorted out and analyzed by bibliometrics. We use CiteSpace, Vosviewer and HistCite to visualize literature information, including national publication statistics, institutions, authors, journal partnerships, and citations of published articles. Results Among the 2942 articles, the United States and China ranked first in both article circulation and TGCS, and many countries also cooperated. The collaboration between schools and research institutions is a core part of dissertation research institution collaboration, with most authors coming from the same institution. Most of the literature studies on the mechanisms and methods of promoting diabetic wound healing. Improving cell function or making innovative attempts in local treatment are the fruits of researchers’ efforts to promote diabetic wound healing in recent years. Conclusion Through the metrology method, the time distribution, author institution, cooperation network, research status, research hotspot and development trend of the literature on the influence of diabetes on wound healing were intuitively displayed, which provided a reference for further research and development direction.

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Section: Discussionmentioning

confidence: 99%

Effect of Diabetes on Wound Healing: A Bibliometrics and Visual Analysis

Lang,

Li,

et al. 2024

JMDH

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“…The most common complication associated with diabetes mellitus is diabetic neuropathy [7]. Diabetic foot ulcer a serious problem resulting from unregulated diabetes, causing significant sickness and death rates [8]. Beyond its primary action on the pancreas, glipizide has been found to enhance insulin sensitivity and decrease hepatic glucose synthesis [9].…”

Section: Encyclopaedic Review Of Glipizide Pre-clinical and Clinical ...mentioning

confidence: 99%

Encyclopaedic Review of Glipizide Pre-clinical and Clinical Status

Mohammed,

Mahmood,

Shamim

et al. 2024

Drug Res (Stuttg)

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Glipizide is an oral glucose-lowering medication that is beneficial for the treatment of type 2 diabetes. This study compiles exhaustively all accessible information on glipizide, from preclinical to clinical studies. Glipizide may be used in concert with TRAIL to treat cancer cells; in vitro studies have shown that it suppresses angiogenesis and vasculogenesis while shielding cells from glycation-induced damage. Anticonvulsant effects and modifications in the pharmacokinetics of other medications, such as Divalproex Sodium, were seen in glipizide in vivo experiments. Propranolol amplifies glipizide's hypoglycemic effect briefly in normal animals but consistently enhances it in diabetic ones. In the treatment of cancer and neurodegenerative poly(Q) illnesses, glipizide has demonstrated to offer potential therapeutic advantages. It is ineffective in preventing DENA-induced liver cancer and may cause DNA damage over time. The way glipizide interacts with genetic variants may increase the risk of hypoglycemia. Combining Syzygium cumini and ARBE to glipizide may enhance glycemic and lipid control in type 2 diabetes. Individuals with coronary artery disease who take glipizide or glyburide have an increased risk of death. The risk of muscular responses and acute pancreatitis is minimal when glipizide and dulaglutide are combined. In conclusion, glipizide has shown promising therapeutic efficacy across a variety of disorders.

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“…Lower extremity arterial disease (LEAD) is one of the main causes of disability and death due to foot ulcers in diabetic patients, and currently, severe LEAD is mainly treated by interventional or lower extremity artery bypass graft surgery, while mild to moderate LEAD is mainly treated with medical drugs. Nonetheless, the longterm outcome leaves much to be desired [8][9].…”

Section: Introductionmentioning

confidence: 99%

Clinical Efficacy of Antibiotic Bone Cement plus Lateral Bone Repositioning for Severe Diabetic Foot and Its Impact on Wound Healing Rate

Luo,

Zhang,

Cao

et al. 2023

Preprint

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Objective: To evaluate the clinical efficacy of antibiotic bone cement plus lateral bone repositioning for severe diabetic foot and its impact on wound healing rate. Methods: Sixty patients with hemodialysis anemia admitted to the endocrinology department of our hospital from July 2020 to July 2021 were included and randomly assigned to receive antibiotic bone cement plus lateral bone repositioning (observation group) or vacuum sealing drainage (VSD) (control group). Outcome measures included skin temperature of the affected limb, ankle-brachial index, sensory threshold, foot wound healing, dorsalis pedis artery hemodynamics, lower limb function and clinical efficacy. Results: Antibiotic bone cement plus lateral bone repositioning resulted in significantly higher treatment efficiency and transcutaneous partial pressure of oxygen, smaller wound, and lower trauma pH versus VSD, suggesting that antibiotic bone cement plus lateral bone repositioning contributes to potentiating the treatment efficacy and reducing the foot ulcer trauma, thereby facilitating rapid recovery. Patients given antibiotic bone cement plus lateral bone repositioning had larger vascular internal diameter and blood flow and better sensory conduction velocity of the common peroneal nerve and the motor conduction velocity of the tibial nerve versus those given VSD, indicating its vascular and neurological benefits. Conclusion: Antibiotic bone cement plus lateral bone repositioning enhances the treatment efficiency, boosts trauma healing, and promotes postoperative functional recovery of patients.

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Leveraging Potential of Nanotherapeutics in Management of Diabetic Foot Ulcer

Cited by 9 publications

References 69 publications

Effect of Diabetes on Wound Healing: A Bibliometrics and Visual Analysis

Effect of Diabetes on Wound Healing: A Bibliometrics and Visual Analysis

Encyclopaedic Review of Glipizide Pre-clinical and Clinical Status

Clinical Efficacy of Antibiotic Bone Cement plus Lateral Bone Repositioning for Severe Diabetic Foot and Its Impact on Wound Healing Rate

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