Levobuipivacaine-Induced Dissemination of A549 Lung Cancer Cells

Chan, Shun-Ming; Lin, Bo-Feng; Wong, Chih‐Shung; Chuang, Wen-Ting; Chou, Yu‐Ting

doi:10.1038/s41598-017-08885-z

Cited by 12 publications

(14 citation statements)

References 39 publications

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“…Microarray, quantitative real-time polymerase chain reaction (qRT-PCR) and immunoblot analyses revealed that levobupivacaine upregulated the hypoxia-inducible factor (HIF-2α) gene expression in cancer cells, which indicated that HIF-2α signaling may contribute to levobupivacaine-mediated A549 cell dissemination. 29 While in this study, there were no morphological changes observed in A549 cells after Lidocaine and Ropivacaine treatments. 29 However, it was found by the in vitro studies of human lung adenocarcinoma cells that both Lidocaine and Ropivacaine, the amide local anesthetics, can reduce the migration of lung adenocarcinoma cells, but the ester local anesthetic, Chloroprocaine, does not have this function.…”

Section: Narcotic Substancescontrasting

confidence: 54%

“… 29 While in this study, there were no morphological changes observed in A549 cells after Lidocaine and Ropivacaine treatments. 29 However, it was found by the in vitro studies of human lung adenocarcinoma cells that both Lidocaine and Ropivacaine, the amide local anesthetics, can reduce the migration of lung adenocarcinoma cells, but the ester local anesthetic, Chloroprocaine, does not have this function. The effects of Lidocaine and Ropivacaine are achieved by inhibiting important signaling pathways related to tumor growth and metastasis.…”

Section: Narcotic Substancescontrasting

confidence: 54%

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Current Understanding on Perioperative Management in Lung Cancer: Implications for Anesthetic Considerations

Wang¹,

Liu²,

Song³

et al. 2021

DDDT

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Narcotic drugs are often used to treat perioperative pain for patients with lung cancer. However, anesthetic management and narcotic substance use may have significant impacts on patients with lung cancer, including anti-cancer or promoting cancer effects. In this study, we summarize the effects of anesthetic management and its related substances on lung cancer. An evidence-based review of the influence of anesthetic techniques and narcotic substances used on lung cancer was performed. The effects of perioperative pain management and the method of choosing anesthesia for patients with lung cancer were explored. Different management techniques of anesthesia have been indicated to suppress both cell-mediated immunity and humoral immunity and have effects on the recurrence and metastasis of lung cancer. Evidence suggests that the effects of narcotic substances used on lung cancer were still inconsistent. However, the mechanisms by which anesthetics and analgesics inhibit the tumor are complicated. Perioperative management leads to decreased immunity in patients with lung cancer, which to some extent contributes to recurrence and metastasis. Various narcotic substances used may modulate signal pathways, including the mitochondrial pathway, and appear to exert different effects on the recurrence and metastasis of lung cancer. The anesthesiologists should consider these effects on perioperative management with lung cancer.

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Section: Narcotic Substancescontrasting

confidence: 54%

Section: Narcotic Substancescontrasting

confidence: 54%

Current Understanding on Perioperative Management in Lung Cancer: Implications for Anesthetic Considerations

Wang¹,

Liu²,

Song³

et al. 2021

DDDT

View full text Add to dashboard Cite

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“…Anesthesia and analgesia may affect EMT [ 25 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. Studies have reported that propofol suppressed EMT in esophageal cancer, choriocarcinoma, breast cancer, thyroid cancer, lung cancer, gastric cancer, hepatocellular carcinoma (HCC), renal cell carcinoma (RCC), prostate cancer, and oral squamous cell carcinoma cells [ 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 ].…”

Section: Tumor Factors: Emt Hypoxia-inducible Factor-1α (Hif-1α) Matr...mentioning

confidence: 99%

“…Lidocaine suppressed EMT in ovarian cancer cells [ 59 ]. However, high concentrations of levobupivacaine significantly increased EMT in the A549 lung cancer cell line, and enhanced metastasis in mice [ 60 ]. COX-2 inhibitors may suppress EMT in oral squamous cell carcinoma [ 61 ].…”

Section: Tumor Factors: Emt Hypoxia-inducible Factor-1α (Hif-1α) Matr...mentioning

confidence: 99%

Pancreatic Cancer and Microenvironments: Implications of Anesthesia

Lai

Kuo

Huang

et al. 2022

Cancers

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Pancreatic malignancy is a lethal neoplasm, as well as one of the leading causes of cancer-associated mortality, having a 5-year overall survival rate of less than 10%. The average life expectancy of patients with advanced pancreatic cancer does not exceed six months. Although surgical excision is a favorable modality for long-term survival of pancreatic neoplasm, metastasis is initially identified in nearly 80% of the patients by the time of diagnosis, making the development of therapeutic policy for pancreatic cancer extremely daunting. Emerging evidence shows that pancreatic neoplastic cells interact intimately with a complicated microenvironment that can foster drug resistance, metastasis, or relapse in pancreatic cancer. As a result, the necessity of gaining further insight should be focused on the pancreatic microenvironment contributing to cancer progression. Numerous evidence reveals that perioperative factors, including surgical manipulation and anesthetics (e.g., propofol, volatile anesthetics, local anesthetics, epidural anesthesia/analgesia, midazolam), analgesics (e.g., opioids, non-steroidal anti-inflammatory drugs, tramadol), and anesthetic adjuvants (such as ketamine and dexmedetomidine), might alter the tumor microenvironment and cancer progression by affecting perioperative inflammatory or immune responses during cancer surgery. Therefore, the anesthesiologist plays an important role in perioperative management and may affect surgical outcomes. However, the literature on the impact of anesthesia on the pancreatic cancer microenvironment and progression is limited. This review summarizes the current knowledge of the implications of anesthesia in the pancreatic microenvironment and provides future anesthetic strategies for improving pancreatic cancer survival rates.

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“…The local anesthetics lidocaine and bupivacaine do not affect HIF-1-dependent cellular hypoxia-induced gene responses. The question to be considered when considering the effects of local anesthetics is whether they are local or systemic [ 68 , 69 ].…”

Section: Introductionmentioning

confidence: 99%

Hypoxia-dependent signaling in perioperative and critical care medicine

Hirota

2021

J Anesth

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A critical goal of patient management for anesthesiologists and intensivists is to maintain oxygen homeostasis in patients admitted to operation theaters and intensive care units. For this purpose, it is imperative to understand the strategies of the body against oxygen imbalance—especially oxygen deficiency (hypoxia). Adaptation to hypoxia and maintenance of oxygen homeostasis involve a wide range of responses that occur at different organizational levels in the body. These responses are greatly influenced by perioperative patient management including factors such as perioperative drugs. Herein, the influence of perioperative patient management on the body's response to oxygen imbalance was reviewed with a special emphasis on hypoxia-inducible factors (HIFs), transcription factors whose activity are regulated by the perturbation of oxygen metabolism. The 2019 Nobel Prize in Physiology or Medicine was awarded to three researchers who made outstanding achievements in this field. While previous studies have reported the effect of perioperatively used drugs on hypoxia-induced gene expression mediated by HIFs, this review focused on effects of subacute or chronic hypoxia changes in gene expression that are mediated by the transcriptional regulator HIFs. The clinical implications and perspectives of these findings also will be discussed. Understanding the basic biology of the transcription factor HIF can be informative for us since anesthesiologists manage patients during the perioperative period facing the imbalances the oxygen metabolism in organ and tissue. The clinical implications of hypoxia-dependent signaling in critical illness, including Coronavirus disease (COVID-19), in which disturbances in oxygen metabolism play a major role in its pathogenesis will also be discussed.

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Levobuipivacaine-Induced Dissemination of A549 Lung Cancer Cells

Cited by 12 publications

References 39 publications

Current Understanding on Perioperative Management in Lung Cancer: Implications for Anesthetic Considerations

Current Understanding on Perioperative Management in Lung Cancer: Implications for Anesthetic Considerations

Pancreatic Cancer and Microenvironments: Implications of Anesthesia

Hypoxia-dependent signaling in perioperative and critical care medicine

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