Levobupivacaine hydrochloride and sufentanil have no antimicrobial effect at 25°C in vitro

Abstract

Phrenic nerve infiltration with ropivacaine 0.2% 10 mL reduced the incidence and delayed the onset of ipsilateral shoulder pain during the first 24 h after open lung resection, with no clinically relevant effects on respiratory function.

The Comparison of the Effects of Different Doses of Levobupivacaine Infiltration on Wound Healing

“…Hodson et al reported in their study that the antibacterial effects of bupivacaine are higher than that of the levobupivacaine [19]. In another study the authors worked on the combined antibacterial effects of levobupivacaine and sufentanil and found that these two drugs can be used safely in regional anesthesia without any bacterial reproduction at room temperature [20]. We did not encounter any sign of macroscopic infection on the wounds and these results correlate with the prior studies done by other authors.…”

Microbial growth in a mixture of hyperbaric bupivacaine and fentanyl prepared in a multi-dose syringe in the operating theatre environment

“…Since then, interest in the antimicrobial activities of local anaesthetics have spread to clinical disciplines as diverse as dentistry (33), anaesthetics (34)(35)(36)(37)(38)(39)(40)(41)(42), otorhinolaryngology (43), pulmonology (44) and ophthalmology (45,46).…”

“…In contrast to this, however, an in-use clinical study found that morphine and pethidine prepared for titration for individual patients have a high rate of contamination during clinical use (64). There is some evidence that sufentanil may have some synergistic antimicrobial activity when used in combination with bupivacaine (48), although another study found sufentanil to neither inhibit nor encourage microbial growth (40). Tamanai-Shacoori suggests that this non-specific antimicrobial activity of At concentrations of 5mg/ml, pethidine inhibited 6 of 10 organisms.…”

Postthoracotomy Ipsilateral Shoulder Pain: A Literature Review on Characteristics and Treatment

“…Even, one study reported a prevalence of up to 97% [9]. ISP could impair effective breathing and the effectiveness of physical therapy in the early postoperative period [14].…”

“…ISP onset could be as early as the first postoperative hour [9, 11]. With treatment, the pain severity will decrease over the first 4 to 6 hours [5, 11, 13].…”