The Comparison of the Effects of Different Doses of Levobupivacaine Infiltration on Wound Healing

Abstract

We have concluded that levobupivacaine used in clinical doses have a significant effect on the fastening of wound healing and this effect increases with an increase in the concentration of the levobupivacaine. We believe that levobupivacaine will be more widely preferred in the near future in the postoperative analgesia.

Comparação dos efeitos da infiltração com bupivacaína, lidocaína e tramadol na cicatrização de feridas em ratos

“…Masson's trichrome was also applied for histochemical identification of collagenization. H&E and Masson's trichrome stained slides were reviewed by the same pathologist 3,28 .…”

“…When infiltration analgesia is installed before the surgical incision, it preemptively increases analgesic efficiency during and after the operation; additionally, it protects against chronic pain 3,5 .…”

“…Local anesthetic agents commonly used for surgical wound infiltration include lidocaine, prilocaine, bupivacaine, ropivacaine and levobupivacaine 1,[3][4][5][6][7][8][9][10][11][12] . Tramadol is a synthetic analogue of codeine, which acts through both opioid and non-opioid mechanisms of action 1,13 .…”

“…For this reason, it is important to know not just the effects of the wound infiltration agents on postoperative pain but their effect in detail on wound healing and whether they are a cause of morbidity in clinical use 3,[28][29][30][31] . Previous research using experimental models and fibroblast tissue cultures from surgical wounds had looked at the effect of local anesthetic agents such as bupivacaine, prilocaine and lidocaine on wound healing 3,28-31 .…”

“…Infiltrating the wound with local anesthetics is increasingly used as a post-operative analgesia method due to its ease of application, simplicity and few side effects [1][2][3][4] . Surgical wound infiltration, especially after minor to intermediate surgeries, reduces post-operative opioid consumption and related complications, hospital stay time and costs 4 .…”