Local infiltration of the surgical wounds with levobupivacaine, dexibuprofen, and norepinephrine to reduce postoperative pain: A randomized, vehicle–controlled, and preclinical study

Gao, Zongwen; Feng, Cui; Cao, Xuemei; Wang, Dejun; Li, Xiao; Li, Tianzuo

doi:10.1016/j.biopha.2017.05.038

Cited by 18 publications

(11 citation statements)

References 21 publications

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“…The prior sample size was found to be 162 in each of 5 group (simple randomization). The parameters were considered as population size (N): 900, hypothesized% frequency ( p ): 85±5%, confidence limit: 95%, and design effect: 1 [ 12 ]. The 5-arm study tree is presented in Figure 2 .…”

Section: Methodsmentioning

confidence: 99%

Effects of Increased Frequency, High Dose, and Pulsatile Oxytocin Regimens on Abnormal Labor Delivery

Liu

Yang

2018

Med Sci Monit

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BackgroundThe current guideline for oxytocin regimens in the abnormal labor of delivery is continuous infusion. The objective of the present study was to compare effects and safety measures of various available regimens of oxytocin in abnormal labor delivery.Material/MethodsIn this clinical experimental study, a total of 900 pregnant women admitted for delivery were randomized into 5 group with 162 each. Pregnant women received oxytocin as continuous administration of 16 mU/min (Group I), 1 mU/min (group II), 4 mU/min (group III), 5 mU/min quarter-hourly (group IV), and through a syringe pump (group V). Measurement of the expense of delivery, the ratio of the instrumental delivery, and the other secondary outcome measures was performed to find the best regimen of oxytocin. The 2-tailed paired t test and Mann-Whitney U test following Dunnett’s multiple comparison tests were used at 95% confidence level.ResultsPulsatile delivery had least risk of instrumental delivery as compared to continuous infusion (p<0.0001, q=6.663) and normal-frequency low-dose (p<0.0001, q=5.638) of oxytocin. The time required from infusion to delivery was longer for group II (p=0.001, q=2.925), group IV (p<0.0001, q=4.829), and group V (p<0.0001, q=41.456) than for group I. The expense of delivery was: group I < group II < group IV < group III < group V.ConclusionsHigh-dose and pulsatile preparation of oxytocin had reduced risks of operative delivery vs. continuous administration.

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Section: Methodsmentioning

confidence: 99%

Effects of Increased Frequency, High Dose, and Pulsatile Oxytocin Regimens on Abnormal Labor Delivery

Liu

Yang

2018

Med Sci Monit

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“…Many times, epinephrine is used to prolong the duration and lower the toxicity of the drug used [50,51]. The influence of pain in the wound healing has been studied too [52][53][54]. The wound healing in the fetus has also been the object of research [55,56].…”

Section: Local Anesthetics Can Influence the Process Of Wound Healing?mentioning

confidence: 99%

Local Anesthetics Infiltration and Wound Healing Process

Abrão¹,

Antunes²,

Garcia³

2020

Topics in Local Anesthetics

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It is a good practice, nowadays, to infiltrate local anesthetics along the incision to prevent postoperative pain. This can reduce the use of opioids and the side effects they cause. It is known clearly that the surgical trauma causes inflammatory reaction, and this can be the beginning of a bad cicatrization or even a scar. The use of local anesthetics preventing the acute pain is a very simple technique and has proved to be useful. Nevertheless, the reaction that various anesthetics have over the tissues and the cicatrization process is yet controversial and deserves to be investigated deeply. The use of different formulations of these drugs has been stimulated. The duration and secureness have been the goals of many researches. Levobupivacaine, ropivacaine, and bupivacaine for their long action; lidocaine for less toxicity; and liposomal formulation for the longest duration ever seen, all of them have been indicated in the postoperative pain management. The aim of this chapter is to evaluate the role of long duration local anesthetics on the inflammatory reaction and consequently the collagen production and resistance of the tissue to traction.

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“…Weight variation test and disintegration time for capsule formulation of SSEDDS were also evaluated. 20 24 InStat (GraphPad, USA) software was used for statistical analysis. The results were considered signifi cant at 95% of confi dence level.…”

Section: Preparation Of Solid Sedds Formulations (Ssedds)mentioning

confidence: 99%

Formulation Studies of Solid Self-Emulsifying Drug Delivery System of Ivermectin

2018

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Background: The suggested dose of ivermectin is 300 μG/kg/day for onchocerciasis but it has low water solubility and poor oral bioavailability. Aim: To prepare and evaluate a solid lipid-based self-emulsifying drug delivery system of ivermectin. Materials and methods: Based on supersaturated solubility study, oil, surfactant, and co-surfactant were selected. On the basis of ternary phase diagrams and simplex-lattice design, self-emulsifying, drug delivery formulations had been developed and optimized. Ivermectin-excipients compatibility studies were performed using differential scanning calorimetry and Fourier transform infrared spectroscopy. Solid self-emulsifying drug delivery formulation was formulated from the optimized batch by surface assimilation method and filled into hard gelatin capsules. In vitro release rate and in vivo pharmacokinetic parameters of ivermectin from the capsules were determined. Two-tailed paired t-test/Dunnett multiple comparison tests were performed for in vivo pharmacokinetic parameter at 95 % of confidence level. Results: Soybeans oil, tween 80, and span 80 were selected as oil, surfactant, and co-surfactant respectively. The ternary diagrams were shown the maximum area for emulsion in 1:2 surfactant/co-surfactant ratio. The optimized batch had found with 30 mg ivermectin, 6.17 g soybeans oil, 0.30 g tween 80, and 3.50 g span 80. All differential scanning calorimetry and Fourier transform infrared characteristic peaks of the optimized formulation were identical with that of pure ivermectin. The area under the curve of ivermectin from the capsule was about two-fold higher than that of ivermectin suspension. Conclusions: Solid self-emulsifying drug delivery system was an effective oral solid dosage form to improve the oral bioavailability of ivermectin.

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Local infiltration of the surgical wounds with levobupivacaine, dexibuprofen, and norepinephrine to reduce postoperative pain: A randomized, vehicle–controlled, and preclinical study

Cited by 18 publications

References 21 publications

Effects of Increased Frequency, High Dose, and Pulsatile Oxytocin Regimens on Abnormal Labor Delivery

Effects of Increased Frequency, High Dose, and Pulsatile Oxytocin Regimens on Abnormal Labor Delivery

Local Anesthetics Infiltration and Wound Healing Process

Formulation Studies of Solid Self-Emulsifying Drug Delivery System of Ivermectin

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