Levodopa Improves Spatial Contrast Sensitivity in Parkinson's Disease

Jt, Hutton; Jl, Morris; Jw, Elias

doi:10.1001/archneur.1993.00540070041012

Cited by 76 publications

(46 citation statements)

References 13 publications

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“…The most prominent interaction between CS disturbance and retinal dopamine has been revealed in patients with motor fluctuations during the «on» and «off» periods. Our evidence of improved CS during the «on» period and reduced CS during the «off» period is agreement with data published by authors from other countries and demonstrates that CS can vary due to the effect of levodopa drugs [20][21][22]. However, what defines the variability of CS fluctuation in different patients is still unknown.…”

Section: IIIsupporting

confidence: 91%

Clinical Significance and Pathogenesis of Visual Impairment in Parkinson’s Disease

Oa¹,

Sa²,

Oi³

2017

JNSK

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Among non-motor symptoms in patients with Parkinson's disease (PD) have a number of specific visual disturbances. This review describes the main visual problems associated with PD, referring to their basic anatomical aspects and pathophysiological mechanisms. A wide range of visual disorders includes changes in color vision and contrast sensitivity, change in the electrophysiological properties of the retina due to the insufficiency of the retinal dopaminergic system, features of visual field defects, visuospatial and visuoperceptual impairments. The use of modern electrophysiological, neurophysiological, psychophysiological and other research methods makes it possible to comprehensively assess the state of all parts of the visual analyzer from the retina to the higher cortical centers in patients with PD. The article discusses controversial questions about the relationship between changes in color vision, a decrease in the level of contrast sensitivity and severity of motor disorders in Parkinson's disease. Finally, we discuss the advantages of using threshold and blue-yellow perimetry as more sensitive methods in detecting visual field defects in patients with PD. Keywords:

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Section: IIIsupporting

confidence: 91%

Clinical Significance and Pathogenesis of Visual Impairment in Parkinson’s Disease

Oa¹,

Sa²,

Oi³

2017

JNSK

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“…The use of the Farnsworth-Munsell test however needs to take into consideration motor function as there was a correlation between fine motor performance and color discrimination in one study [29]. Additionally, dopaminergic treatment may affect both color discrimination and contrast sensitivity [30,31].…”

Section: While Many Patients With Pd Complain Of Blurred Vision or Nomentioning

confidence: 99%

Premotor Symptoms and Early Diagnosis of Parkinson's Disease

Adler

2011

International Journal of Neuroscience

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“…Reduced contrast sensitivity (CS) is a common feature of Parkinson disease (PD) [1][2][3][4][5][6][7][8][9][10][11] and is associated with poor outcomes on driving tests in parkinsonian drivers. [12][13][14] However, there are no published reports on driving under low visibility due to low-contrast lighting conditions in PD.…”

mentioning

confidence: 99%

Driving under low-contrast visibility conditions in Parkinson disease

Uç¹,

Rizzo²,

Anderson³

et al. 2009

Neurology

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Objective: To assess driving performance in Parkinson disease (PD) under low-contrast visibility conditions. Methods:Licensed, active drivers with mild to moderate PD (n ϭ 67, aged 66.2 Ϯ 9.0 years, median Hoehn-Yahr stage ϭ 2) and controls (n ϭ 51, aged 64.0 Ϯ 7.2 years) drove in a driving simulator under high-(clear sky) and low-contrast visibility (fog) conditions, leading up to an intersection where an incurring vehicle posed a crash risk in fog.Results: Drivers with PD had higher SD of lateral position (SDLP) and lane violation counts (LVC) than controls during fog (p Ͻ 0.001). Transition from high-to low-contrast visibility condition increased SDLP and LVC more in PD than in controls (p Ͻ 0.01). A larger proportion of drivers with PD crashed at the intersection in fog (76.1% vs 37.3%, p Ͻ 0.0001). The time to first reaction in response to incursion was longer in drivers with PD compared with controls (median 2.5 vs 2.0 seconds, p Ͻ 0.0001). Within the PD group, the strongest predictors of poor driving outcomes under low-contrast visibility conditions were worse scores on measures of visual processing speed and attention, motion perception, contrast sensitivity, visuospatial construction, motor speed, and activities of daily living score. Conclusions:During driving simulation under low-contrast visibility conditions, drivers with Parkinson disease (PD) had poorer vehicle control and were at higher risk for crashes, which were primarily predicted by decreased visual perception and cognition; motor dysfunction also contributed. Our results suggest that drivers with PD may be at risk for unsafe driving in low-contrast visibility conditions such as during fog or twilight. Neurology Reduced contrast sensitivity (CS) is a common feature of Parkinson disease (PD)1-11 and is associated with poor outcomes on driving tests in parkinsonian drivers.12-14 However, there are no published reports on driving under low visibility due to low-contrast lighting conditions in PD. This study evaluates the effect of different environmental visibility settings (high contrast ϭ clear sky, low contrast ϭ fog, as in figure 1) on vehicle control (indexed by SD of lateral position [SDLP] and lane violation counts [LVC]) during uneventful driving, and response to sudden hazards under low-contrast visibility conditions in drivers with PD using a driving simulator.To test driver response to a sudden hazard under low-contrast visibility conditions, we used a collision avoidance scenario at an intersection. [15][16][17] Although intersections constitute only a

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Levodopa Improves Spatial Contrast Sensitivity in Parkinson's Disease

Cited by 76 publications

References 13 publications

Clinical Significance and Pathogenesis of Visual Impairment in Parkinson’s Disease

Clinical Significance and Pathogenesis of Visual Impairment in Parkinson’s Disease

Premotor Symptoms and Early Diagnosis of Parkinson's Disease

Driving under low-contrast visibility conditions in Parkinson disease

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