Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms

Babiloni, Claudio; Percio, Claudio Del; Lizio, Roberta; Noce, Giuseppe; Lopez, Susanna; Soricelli, Andrea; Ferri, Raffaele; Pascarelli, Maria Teresa; Catania, Valentina; Nobili, Flavio; Arnaldi, Dario; Famà, Francesco; Orzi, Francesco; Buttinelli, Carla; Giubilei, Franco; Bonanni, Laura; Franciotti, Raffaella; Onofrj, Marco; Stirpe, Paola; Fuhr, Peter; Gschwandtner, Ute; Ransmayr, Gerhard; Fraioli, Lucia; Parnetti, Lucilla; Farotti, Lucia; Pievani, Michela; D'Antonio, Fabrizia; Lena, Carlo de; Güntekin, Bahar; Hanoğlu, Lütfü; Yener, Görsev; Emek‐Savaş, Derya Durusu; Triggiani, Antonio Ivano; Taylor, John‐Paul; McKeith, Ian G.; Stocchi, Fabrizio; Vacca, Laura; Frisoni, Giovanni B.; Pandis, Maria Francesca De

doi:10.1016/j.neurobiolaging.2018.08.010

Cited by 32 publications

(34 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A further potential limitation is the use of dopaminergic medication in many LBD patients which has also been shown to influence EEG signals by increasing eyesclosed alpha power [46,47]. However, we did not find differences between LBD patients who were taking dopaminergic medication compared to those patients not taking these medications, and there were no significant correlations between LEDD and the EEG measures included in the present study.…”

Section: Discussioncontrasting

confidence: 70%

EEG alpha reactivity and cholinergic system integrity in Lewy body dementia and Alzheimer’s disease

et al. 2020

View full text Add to dashboard Cite

Background: Lewy body dementia (LBD), which includes dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), is characterised by marked deficits within the cholinergic system which are more severe than in Alzheimer's disease (AD) and are mainly caused by degeneration of the nucleus basalis of Meynert (NBM) whose widespread cholinergic projections provide the main source of cortical cholinergic innervation. EEG alpha reactivity, which refers to the reduction in alpha power over occipital electrodes upon opening the eyes, has been suggested as a potential marker of cholinergic system integrity. Methods:Eyes-open and eyes-closed resting state EEG data were recorded from 41 LBD patients (including 24 patients with DLB and 17 with PDD), 21 patients with AD, and 40 age-matched healthy controls. Alpha reactivity was calculated as the relative reduction in alpha power over occipital electrodes when opening the eyes. Structural MRI data were used to assess volumetric changes within the NBM using a probabilistic anatomical map. Results: Alpha reactivity was reduced in AD and LBD patients compared to controls with a significantly greater reduction in LBD compared to AD. Reduced alpha reactivity was associated with smaller volumes of the NBM across all groups (ρ = 0.42, p FDR = 0.0001) and in the PDD group specifically (ρ = 0.66, p FDR = 0.01). Conclusions:We demonstrate that LBD patients show an impairment in alpha reactivity upon opening the eyes which distinguishes this form of dementia from AD. Furthermore, our results suggest that reduced alpha reactivity might be related to a loss of cholinergic drive from the NBM, specifically in PDD.

show abstract

Section: Discussioncontrasting

confidence: 70%

EEG alpha reactivity and cholinergic system integrity in Lewy body dementia and Alzheimer’s disease

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The relative bandpower in α band showed a decreasing trend in the longitudinal changes from PD-CogNl to PD-MCI to PDD as well as cortical changes were observed in PD patients (Babiloni et al, 2011(Babiloni et al, , 2019Caviness et al, 2016). PD patients had lower occipital α source compared to HC whilst PDD patients showed increased frontal-temporal α source and abnormal sources of posterior cortical β1 rhythm (Soikkeli et al, 1991;Babiloni et al, 2011Babiloni et al, , 2019. As the changes of β band power are related to gait initiation failure (GIF) events, abnormal β oscillation may be a biomarker of motor impairment in PD patients (Palmer et al, 2010;Quynh Tran et al, 2016).…”

Section: Eeg Spectral Characteristicsmentioning

confidence: 90%

“…The diminished β power ERD and prolonged β ERS in an attentional experiment suggest that the coupling between attention and motor preparation was impaired in PD-FOG (Tard et al, 2016). The relative bandpower in α band showed a decreasing trend in the longitudinal changes from PD-CogNl to PD-MCI to PDD as well as cortical changes were observed in PD patients (Babiloni et al, 2011(Babiloni et al, , 2019Caviness et al, 2016). PD patients had lower occipital α source compared to HC whilst PDD patients showed increased frontal-temporal α source and abnormal sources of posterior cortical β1 rhythm (Soikkeli et al, 1991;Babiloni et al, 2011Babiloni et al, , 2019.…”

Section: Eeg Spectral Characteristicsmentioning

confidence: 91%

Characterization of EEG Data Revealing Relationships With Cognitive and Motor Symptoms in Parkinson's Disease: A Systematic Review

Wang

Meng

Pang

et al. 2020

Front. Aging Neurosci.

View full text Add to dashboard Cite

“…Three of the studies that split alpha into lower and upper frequencies found less lower alpha power in people with PD-MCI compared to cognitively healthy PD patients (Babiloni et al [101], n = 35 PD-D, 50 PD-MCI, 35 PD-CH; Bousleiman et al [102], n = 41 PD-MCI, 12 PD-CH) and in people with DLB-MCI compared to cognitively healthy older adults (Babiloni et al [103], n = 23 DLB-MCI, 30 OA). Babiloni et al also observed less upper alpha power in people with DLB-MCI compared to cognitively healthy older adults (Babiloni et al [103], n = 23 DLB-MCI, 30 OA), but more upper alpha power in people with PD-MCI compared to cognitively healthy PD patients and in people with PD-D compared to those with PD-MCI (Babiloni et al [101], n = 35 PD-D, 50 PD-MCI, 35 PD-CH). The latter study was the only one that investigated alpha power in PD-MCI in individually defined alpha bands.…”

Section: Alpha Power and Functional Connectivity During Wakeful Restmentioning

confidence: 99%

“…We also observed that EEG was mostly recorded with a small number of electrodes, which could lead to imprecise measures of alpha power and connectivity in source space, and alpha connectivity in sensor space. Most studies that measured alpha at reconstructed sources used 19 or 20 electrodes [56,72,81,89,94,98,101,103,110,115,207], which is, according to COBIDAS-MEEG guidelines [82], not sufficient for precise source localization. Furthermore, when connectivity is measured in sensor space with a small number of electrodes and without spatial filters, it can lead to spurious connections.…”

Section: Limitations and Future Directionsmentioning

confidence: 99%

Alpha Power and Functional Connectivity in Cognitive Decline: A Systematic Review and Meta-Analysis

Lejko

Larabi

Herrmann

et al. 2020

JAD

View full text Add to dashboard Cite

Background: Mild cognitive impairment (MCI) is a stage between expected age-related cognitive decline and dementia. Dementias have been associated with changes in neural oscillations across the frequency spectrum, including the alpha range. Alpha is the most prominent rhythm in human EEG and is best detected during awake resting state (RS). Though several studies measured alpha power and synchronization in MCI, findings have not yet been integrated. Objective: To consolidate findings on power and synchronization of alpha oscillations across stages of cognitive decline. Methods: We included studies published until January 2020 that compared power or functional connectivity between 1) people with MCI and cognitively healthy older adults (OA) or people with a neurodegenerative dementia, and 2) people with progressive and stable MCI. Random-effects meta-analyses were performed when enough data was available. Results: Sixty-eight studies were included in the review. Global RS alpha power was lower in AD than in MCI (ES = –0.30; 95% CI = –0.51, –0.10; k = 6), and in MCI than in OA (ES = –1.49; 95% CI = –2.69, –0.29; k = 5). However, the latter meta-analysis should be interpreted cautiously due to high heterogeneity. The review showed lower RS alpha power in progressive than in stable MCI, and lower task-related alpha reactivity in MCI than in OA. People with MCI had both lower and higher functional connectivity than OA. Publications lacked consistency in MCI diagnosis and EEG measures. Conclusion: Research indicates that RS alpha power decreases with increasing impairment, and could—combined with measures from other frequency bands—become a biomarker of early cognitive decline.

show abstract

Levodopa may affect cortical excitability in Parkinson's disease patients with cognitive deficits as revealed by reduced activity of cortical sources of resting state electroencephalographic rhythms

Cited by 32 publications

References 68 publications

EEG alpha reactivity and cholinergic system integrity in Lewy body dementia and Alzheimer’s disease

EEG alpha reactivity and cholinergic system integrity in Lewy body dementia and Alzheimer’s disease

Characterization of EEG Data Revealing Relationships With Cognitive and Motor Symptoms in Parkinson's Disease: A Systematic Review

Alpha Power and Functional Connectivity in Cognitive Decline: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About