Lewis a blood group antigen of non-secretors: a receptor for candida blastospores

May, Shaun

doi:10.1016/0378-1097(89)90266-8

Cited by 13 publications

(15 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A hypothesis has been suggested that the decreased susceptibility of secretors to peptic ulcer disease is due to the presence of terminal fucose resi-dues of H type 2 and Le being important receptors for H. pylori, and that the presence of these antigenic determinants in the mucosa of secretors, protects them from heavy colonisation by infecting organisms [12]. Previous reports have demonstrated that epithelial cells of non-secretors bind larger numbers of micro-organisms than cells of secretors, speci¢cally, uropathogenic strains of Escherichia coli [15], Candida albicans [16], and Staphylococcus aureus [9].…”

Section: Discussionmentioning

confidence: 99%

Effect of host Lewis and ABO blood group antigen expression on Helicobacter pylori colonisation density and the consequent inflammatory response

Heneghan¹

1998

FEMS Immunology and Medical Microbiology

View full text Add to dashboard Cite

The Lewis(b) blood group antigen has been implicated as a putative receptor for Helicobacter pylori in the gastric mucosa. Furthermore, an increased prevalence of duodenal ulcer was found in non-secretors and it has been suggested that secretor status may influence bacterial colonisation density. Other investigators have hypothesised that severity of antral gastritis may be related to colonisation density of the bacterium alone, and that a critical bacterial load is necessary for the development of duodenal ulcer. Our objectives were to investigate whether a relationship existed between host Lewis and ABO blood group phenotype and prevalence of H. pylori infection. In addition we investigated whether bacterial colonisation density and the ensuing inflammatory response was influenced by secretor status and ABO blood group phenotype. The Lewis and ABO blood group phenotype of 207 patients undergoing upper endoscopy was determined. Of these, 136 were secretors and 62 were nonsecretors. Forty-five percent of patients were infected with H. pylori. No significant association was found between H. pylori infection and expression of Lewis(a) or Lewis(b) blood group antigen. The mean histological density of H. pylori was 1.8 +/- 0.2 among non-secretors and 1.51 +/- 0.13 among secretors (P = 0.209), with a mean grade of lymphocytic infiltration significantly greater in H. pylori-infected non-secretors (2.23 +/- 0.123 vs 1.8 +/- 0.074; P = 0.003). In addition, blood group O non-secretors had a significantly higher grade of lymphocyte infiltration of their gastric mucosa compared to non-O non-secretors (2.53 +/- 0.133 vs 1.93 +/- 0.181, P = 0.027). These results suggest that although no in vivo relationship exists between H. pylori and preferential adhesion to the putative Lewis(b) receptor, bacterial colonisation and the ensuing inflammatory response may be influenced at least in part by host expression of ABO and Lewisa blood group antigens.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of host Lewis and ABO blood group antigen expression on Helicobacter pylori colonisation density and the consequent inflammatory response

Heneghan¹

1998

FEMS Immunology and Medical Microbiology

View full text Add to dashboard Cite

show abstract

“…Several studies have reported that the epithelial cells of non-secretors bind larger numbers of some microorganisms than cells of secretors: uropathogenic strains ofEscherichia coli [19]; C. albicans [20,21]; and meningococci [unpublished results]. Although bacteria can bind to proteins on epithelial surfaces, carbohydrates appear to be the receptors recognized by many bacterial adhesins, probably due to their abundance and variety [22].…”

Section: Discussionmentioning

confidence: 99%

ABO blood group, secretor status and detection ofHelicobacter pyloriamong patients with gastric or duodenal ulcers

Mentis

Blackwell²,

Weir³

et al. 1991

Epidemiol. Infect.

View full text Add to dashboard Cite

SUMMARYPatients (454) referred for gastroscopy to the General Hospital of Athens were examined to determine (1) if non-secretors were over-represented among patients with ulcers and (2) is there was an association with ABO blood group or secretor status and carriage of Helicobacter pylorn.Compared with the local population, among patients with either gastric ulcer (51) or duodenal ulcer (96) there was a significant increase in the proportion of those who were blood group 0 (P < 0 025); however, there were no significant differences in the proportions of non-secretors. H. pylori was identified in 62 % of the 454 patients: 59.5 % of those without evidence of ulcers; 62-5 % of those with gastric ulcer; 88 % of those with duodenal ulcer (P < 0-0005). These bacteria were cultured more often and in higher numbers from patients with duodenal ulcer (P < 0 025). There was no association between ABO blood group and prevalence of H. pylori. The prevalence of H. pylorn among non-secretors with gastric ulcer (12-5 %) was significantly lower than that for non-secretors with duodenal ulcer (100 %) (P < 0 0005). This was not observed for secretors.

show abstract

“…One of the hypotheses proposed to explain the increased proportion of nonsecretors among carriers of some potentially pathogenic bacteria and yeasts is that the Lewisa antigen is one of the host cell receptors for some microorganisms [19,21,22]. In this context, the reported high proportion of infants expressing Lewis antigens during the first year of life was of particular interest [23].…”

Section: Introductionmentioning

confidence: 99%

Factors enhancing adherence of toxigenicStaphylococcus aureusto epithelial cells and their possible role in sudden infant death syndrome

et al. 1993

View full text Add to dashboard Cite

SUMMARYToxigenic strains of Staphylococcus aureus have been suggested to play a role in sudden infant death syndrome (SIDS). In this study we examined two factors that might enhance binding of toxigenic staphylococci to epithelial cells of infants in the age range in which cot deaths are prevalent: expression of the Lewisa antigen and infection with respiratory syncytial virus (RSVT). By flow cytometry we demonstrated that binding of three toxigenic strains of S. aureus to cells from nonsecretors was significantly greater than to cells of secretors. Pre-treatment of epithelial cells with monoclonal anti-Lewisa or anti-type-I precursor significantly reduced bacterial binding (P < 0 01); however, attachment of the bacteria correlated only with the amount of Lewisa antigen detected on the cells (P < 0 01). HEp-2 cells infected with RSV bound significantly more bacteria than uninfected cells. These findings are discussed in context, of factors previously associated with SIDS (mother's smoking, bottle feeding and the prone sleeping position) and a hypothesis proposed to explain some cases of SIDS.

show abstract

Lewis a blood group antigen of non-secretors: a receptor for candida blastospores

Cited by 13 publications

References 4 publications

Effect of host Lewis and ABO blood group antigen expression on Helicobacter pylori colonisation density and the consequent inflammatory response

Effect of host Lewis and ABO blood group antigen expression on Helicobacter pylori colonisation density and the consequent inflammatory response

ABO blood group, secretor status and detection ofHelicobacter pyloriamong patients with gastric or duodenal ulcers

Factors enhancing adherence of toxigenicStaphylococcus aureusto epithelial cells and their possible role in sudden infant death syndrome

Contact Info

Product

Resources

About