Lewis Acids in Organic Synthesis. Approach to a Selection Strategy for Screening Experiments.

Principal properties (PPs) for lanthanide triflates as Lewis‐acid catalysts

“…In order to fulfill the above requirement, the concept of principal properties (PPs), that is of intrinsic properties representative of experimentally observable macroscopic descriptors, has recently been introduced. PPs, calculated as the principal component analysis (PCA) scores from several experimentally measured properties, are now available for solvents [15,16], aldehydes [17] and ketones [17], amines [18], Lewis acids [19], aromatic substituents [20] and amino acids [21][22][23][24]. First and second generation PPs for heteroaromatics moieties, based on aromaticity [25] and on 3D-GRID structural parameters, [26] …”

Catalysis of the Diels-Alder Reaction by Organotin Halides

“…The catalytic properties of the Lewis acids and the increased regioselectivity in the presence of a Lewis acid has been treated theoretically by Alston and Ottenbrite 6 and Houk and Strozier 7 . However, Carlson and coworkers 8 found limited Diels-Alder catalytic activity for a number of tin(II) and tin(IV) halides. Likewise, tin(IV) chloride was not an effective catalyst for a Diels-Alder reaction with a stereofacially differentiated enone 9 .…”

Exploring organic synthetic experimental procedures

“…[51] This study was made to check whether or not selections from score plots would permit suitable Lewis acid catalysts to be found. A set of 28 Lewis acids were characterized by ten property descriptors compiled from the literature.…”

“…After the initial study shown above, the stuy was augmented to include 116 Lewis acids and 20 descriptors [51]. Two significant components (cross-validation) accounted for 65% of the total variance.…”

“…Selected • items: (a) ketones, (b) Lewis acids, (e) solvents are marked with dots. For identification numbers in the score plots, see Refs [51,55,61]. …”