Lewis and Secretor Gene Effects on Lewis Antigen and Postnatal Development of Lewis Blood Type

Ameno, Setsuko; Kimura, Hiroko; Ameno, Kiyoshi; Zhang, Xia; Kojima, Hiroshi; Kubota, Takako; Ijiri, Iwao

doi:10.1159/000047073

Cited by 12 publications

(10 citation statements)

References 19 publications

(20 reference statements)

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“…These genotypic variations in the neonate-specific P[6]VP8* constrain the orientation of the reducing end of the type I glycan restricting its ability to bind branched glycans. This may be an important factor in conferring the age-restricted tropism of certain P[6] strains because precursor glycans and unbranched structures are more abundant in the neonatal gut and branching at the reducing end is developmentally regulated 35 , 42 …”

Section: Resultsmentioning

confidence: 99%

“…Our structural studies provide a possible structural rationale for the neonate specificity observed in some P[6] HRV strains. In the neonate gut, modification to the precursor moieties or the branching at the reducing end is developmentally regulated 35 , 42 . While ABH and Lewis HBGAs are also present, the most abundant type in the neonate gut is the unbranched type I precursor glycans 35 , 49 .…”

Section: Discussionmentioning

confidence: 99%

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Glycan recognition in globally dominant human rotaviruses

Sankaran

Laucirica

et al. 2018

Nat Commun

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Rotaviruses (RVs) cause life-threatening diarrhea in infants and children worldwide. Recent biochemical and epidemiological studies underscore the importance of histo-blood group antigens (HBGA) as both cell attachment and susceptibility factors for the globally dominant P[4], P[6], and P[8] genotypes of human RVs. How these genotypes interact with HBGA is not known. Here, our crystal structures of P[4] and a neonate-specific P[6] VP8*s alone and in complex with H-type I HBGA reveal a unique glycan binding site that is conserved in the globally dominant genotypes and allows for the binding of ABH HBGAs, consistent with their prevalence. Remarkably, the VP8* of P[6] RVs isolated from neonates displays subtle structural changes in this binding site that may restrict its ability to bind branched glycans. This provides a structural basis for the age-restricted tropism of some P[6] RVs as developmentally regulated unbranched glycans are more abundant in the neonatal gut.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Glycan recognition in globally dominant human rotaviruses

Sankaran

Laucirica

et al. 2018

Nat Commun

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“…Indeed, P[6] strains have been isolated from asymptomatic neonates from South Africa, Venezuela, Australia, Brazil, Sweden and India 38 – 41 . Furthermore, expression of HBGAs may also be developmentally regulated and different in children <1–2 month of age 42 , and the observed genetic susceptibility may not be absolute, particularly in the very young.…”

Section: Discussionmentioning

confidence: 99%

The Lewis A phenotype is a restriction factor for Rotateq and Rotarix vaccine-take in Nicaraguan children

Bucardo

Nordgren

Reyes

et al. 2018

Sci Rep

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Histo-blood group antigens (HBGAs) and the Lewis and secretor antigens are associated with susceptibility to rotavirus infection in a genotype-dependent manner. Nicaraguan children were prospectively enrolled in two cohorts vaccinated with either RotaTeq RV5 (n = 68) or Rotarix RV1 (n = 168). Lewis and secretor antigens were determined by saliva phenotyping and genotyping. Seroconversion was defined as a 4-fold increase in plasma IgA antibody titer 1 month after administration of the first dose of the vaccine. Regardless of the vaccine administered, significantly fewer of the children with Lewis A phenotype (0/14) seroconverted after receiving the first vaccine dose compared to 26% (45/175) of those with the Lewis B phenotype and 32% (15/47) of the Lewis negative individuals (P < 0.01). Furthermore, following administration of the RV1 vaccine, secretor-positive ABO blood group B children seroconverted to a significantly lesser extent (5%) compared to secretor-positive children with ABO blood groups A (26%) and O (27%) (P < 0.05). Other factors such as pre-vaccination titers, sex, breastfeeding, and calprotectin levels did not influence vaccine-take. Differences in HBGA expression appear to be a contributing factor in the discrepancy in vaccine-take and thus, in vaccine efficacy in different ethnic populations.

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“…Individuals of Le(a+b+) blood type are Se weak Le+ partial secretors ( 23 ). For Le − individuals, Le(a−b−) can be either Se+ secretors or Se − nonsecretors ( 24 , 25 ). As a result, Le(a+b−) and Le(a−b+) Lewis blood types can be used to directly identify nonsecretor and secretor types of mothers, respectively.…”

Section: Introductionmentioning

confidence: 99%

Systematic Characterization and Longitudinal Study Reveal Distinguishing Features of Human Milk Oligosaccharides in China

Wu¹,

Wu²,

Huo³

et al. 2020

Current Developments in Nutrition

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Abstract Background Human milk oligosaccharides (HMOs) in breast milk contribute to the development of neonatal microbiota and immune system. However, longitudinal studies examining HMOs profiles of Chinese mothers remain scarce. Objective To analyze HMOs profiles including their composition, concentrations, and changes during lactation in milk of Chinese mothers. Methods A total of 822 milk samples from 222 mothers were collected, of which 163 mothers provided single samples. Samples from remaining 59 mothers were collected on day3, day7 and thereafter every 7 or 14 days until day168. 24 HMOs were studied using high-performance anion-exchange chromatography (HPAEC). Secretor and non-secretor status were determined based on Lewis blood types and a defined 2’-Fucosyllactose (2’-FL) threshold. Results 77% of the 222 mothers were secretors and 23% were non-secretors. Longitudinal study involving 59 mothers showed that the total HMOs in secretors were significantly greater than those in non-secretors during the first two weeks. Acidic HMOs decreased significantly during lactation and were similar between secretors and non-secretors. Among neutral HMOs, distinctive differences were observed. Non-fucosylated and α-1–3/4-fucosylated HMOs in non-secretors were significantly higher than those in secretors during the first month. In contrast, α-1–2-fucosylated HMOs in secretors were significantly higher than those in non-secretors throughout 168 days. In secretors, 2'-FL levels peaked at 3.02 ± 0.14 g/L (day3) followed by significant decreases. In non-secretors, 2'-FL levels were fairly low throughout 168 days. Of the 24 studied HMOs, only 3-Fucosyllactose (3-FL) levels increased during lactation in both secretor and non-secretor mothers. Conclusions Our study showed dynamic changes of 24 HMOs in secretors and non-secretors during lactation and revealed unique features of these HMOs profiles in the milk of Chinese mothers. Interestingly, 2'-FL levels in secretors were found to be lower than those of western populations but higher than those of African populations.

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Lewis and Secretor Gene Effects on Lewis Antigen and Postnatal Development of Lewis Blood Type

Cited by 12 publications

References 19 publications

Glycan recognition in globally dominant human rotaviruses

Glycan recognition in globally dominant human rotaviruses

The Lewis A phenotype is a restriction factor for Rotateq and Rotarix vaccine-take in Nicaraguan children

Systematic Characterization and Longitudinal Study Reveal Distinguishing Features of Human Milk Oligosaccharides in China

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