Leydig cell ovarian tumor – clinical case description and literature review

Klimek, Marek; Radosz, Patrycja; Lemm, Magdalena; Szanecki, Wojciech; Dudek, Aleksandra; Pokładek, Sandra; Piwowarczyk, Maria; Poński, Michał; Cichoń, Bartosz; Kajor, Maciej; Witek, Andrzej

doi:10.5114/pm.2020.99578

Cited by 7 publications

(7 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recurrent disease might necessitate recurrent surgery, radiotherapy, chemotherapy or even hormonal therapy. Patients should be followed-up appropriately following de nitive therapy [14].…”

Section: Discussionmentioning

confidence: 99%

A Virilizing Malignant Steroid Cell Tumor-Leydig Cell Subtype in a 24-Year-Old Palestinian Female with Challenging Histopathological and Biochemical Features: A Case Report

Arafat

Khaldy

Munshar

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Ovarian steroid cell tumors are a rare subtype of sex-cord stromal cell tumors. Overall, these tumors make less than 0.1% of all ovarian tumors. These neoplasms can be divided according to the cell of origin into stromal luteomas, Leydig cell tumors, and steroid cell tumors not otherwise specified. These tumors can be benign or malignant, with variable presentation. Case presentation: We report a case of 24-year-old virgin Palestinian female who was referred to our hospital after being diagnosed with steroid cell tumor-not otherwise specified. Prior to her admission, the patient had been treated unsuccessfully with oral contraceptive pills due to male-pattern facial hair growth, abdominal cramps and irregular menstrual cycle. The patient did not improve. Ultrasonography demonstrated a large abdominal mass measuring 13x14 cm. Computed tomography confirmed the presence of a large pelvic mass with mixed solid and cystic component, displacing bowel loops peripherally. Hormonal studies showed an elevated dehydroepiandrosterone sulfate (DHEA-S) and morning fasting cortisol. Therefore, unilateral salpingo-oophorectomy was performed, pathological and immunohistochemical examination suggested the presence of a large ovarian steroid cell tumor-not otherwise specified with malignant behavior. The patient did not receive adjuvant therapy and developed metastatic disease. She received 4 cycles of BEP with no improvement, so she was referred to our center to continue oncological management. Case revision confirmed the presence of steroid cell tumor, but of a different subtype, Leydig cell, she received 6 cycles of carboplatin-paclitaxel, albeit inconsistently, her assessment showed disease progression. The patient was referred back to her local hospital to continue management there. Conclusion: Although rare, ovarian steroid cell tumors should be included in the differential diagnosis of virilization in young females, especially those refractory to hormonal therapy. In our study, we aimed to present the first reported Palestinian case, which highlights the importance of detailed morphological examination in addition to the difficulties encountered to reach a proper diagnosis. We also provided a review of the existing literature regarding chemotherapeutic lines used in such cases and the response to each.

show abstract

“…Recurrent disease might necessitate recurrent surgery, radiotherapy, chemotherapy or even hormonal therapy. Patients should be followed-up appropriately following de nitive therapy [14].…”

Section: Discussionmentioning

confidence: 99%

A Virilizing Malignant Steroid Cell Tumor-Leydig Cell Subtype in a 24-Year-Old Palestinian Female with Challenging Histopathological and Biochemical Features: A Case Report

Arafat

Khaldy

Munshar

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Patients should be followed up appropriately following definitive therapy. 14 Our patient underwent unilateral salpingooophorectomy for tissue biopsy and therapy, it was preferred due to the patient young age as a means of fertility preserving. The patient did not receive adjuvant chemotherapy as she had stage IC2 disease.…”

Section: Discussionmentioning

confidence: 99%

“…Recurrent disease might necessitate recurrent surgery, radiotherapy, chemotherapy, or even hormonal therapy. Patients should be followed up appropriately following definitive therapy 14 …”

Section: Discussionmentioning

confidence: 99%

Hirsutism as the initial presentation of malignant ovarian Leydig cell tumor: A case report

Arafat,

Khaldy,

Abu Munshar

et al. 2023

Clinical Case Reports

View full text Add to dashboard Cite

Ovarian steroid cell tumors are a rare subtype of sex‐cord stromal cell tumors. Overall, these tumors make <0.1% of all ovarian tumors. These neoplasms can be divided according to the cell of origin into stromal luteomas, Leydig cell tumors, and steroid cell tumors not otherwise specified. These tumors can be benign, malignant, or borderline, with variable presentation. We report a case of 24‐year‐old virgin female who was referred to our hospital after being diagnosed with steroid cell tumor‐not otherwise specified. Prior to her admission, the patient had been treated unsuccessfully with oral contraceptive pills due to male‐pattern facial hair growth, abdominal cramps, and irregular menstrual cycle. Lack of improvement warranted further investigations. Hormonal studies showed an elevated total testosterone, dehydroepiandrosterone sulfate, and morning fasting cortisol. Ultrasonography and computed tomography confirmed the presence of a large pelvic mass with mixed solid and cystic component. Therefore, unilateral salpingo‐oophorectomy was performed. Pathological and immunohistochemical examination suggested the presence of a large ovarian steroid cell tumor‐not otherwise specified with malignant behavior. The patient did not receive adjuvant therapy and developed metastatic disease. She received four cycles of BEP protocol with no improvement, so she was referred to our center to continue oncological management. Case revision confirmed the presence of steroid cell tumor, but of a different subtype: Leydig cell. She received six cycles of carboplatin‐paclitaxel, but her assessment showed disease progression. We report this case with review of literature regarding the appropriate approach to these rare tumors. Although rare, ovarian steroid cell tumors should be included in the differential diagnosis of virilization in young females, especially those refractory to hormonal therapy. In our study, we aimed to present the first reported Palestinian case, which highlights the importance of detailed morphological examination in addition to the difficulties encountered to reach a proper diagnosis. We also provided a review of the existing literature regarding chemotherapeutic lines used in such cases and the response to each.

show abstract

“…LCTs are sporadic tumors of the stromal sex cord of the ovary, most often occurring in postmenopausal women [ 17 ]. The etiology of the tumor is still unknown.…”

Section: Discussionmentioning

confidence: 99%

The Leydig Steroid Cell Tumor in a Postmenopausal Woman with Clinical and Biochemical Hyperandrogenism: A Case Report

Suturina

Sharifulin

et al. 2022

Metabolites

View full text Add to dashboard Cite

Leydig cell tumors (LCTs) refer to tumors of the stroma of the genital strand, which are found mainly in postmenopausal women. The diagnosis of LCTs in postmenopausal women is associated with specific difficulties and is based on the identification of hyperandrogenism with clinical manifestations of virilization, which has an erased picture in postmenopausal women. LCTs require differential diagnosis with other causes of hyperandrogenism. We present the clinical case of a 55-year-old Russian postmenopausal patient with LCTs of the right ovary, significantly increased levels of androgens, and rapidly progressive clinical signs of hyperandrogenism. The patient underwent laparoscopic bilateral salpingo-oophorectomy, and the androgen indices reached average values by the first and third month after surgery. This case demonstrates that LCTs are often benign with a good prognosis and normalization of the clinical and laboratory manifestations of hyperandrogenism after surgical treatment. The type of surgery performed (bilateral salpingo-oophorectomy rather than unilateral) is recommended as the treatment of choice for LCTs in postmenopausal patients.

show abstract

Leydig cell ovarian tumor – clinical case description and literature review

Cited by 7 publications

References 12 publications

A Virilizing Malignant Steroid Cell Tumor-Leydig Cell Subtype in a 24-Year-Old Palestinian Female with Challenging Histopathological and Biochemical Features: A Case Report

A Virilizing Malignant Steroid Cell Tumor-Leydig Cell Subtype in a 24-Year-Old Palestinian Female with Challenging Histopathological and Biochemical Features: A Case Report

Hirsutism as the initial presentation of malignant ovarian Leydig cell tumor: A case report

The Leydig Steroid Cell Tumor in a Postmenopausal Woman with Clinical and Biochemical Hyperandrogenism: A Case Report

Contact Info

Product

Resources

About