Leydig cell tumor in grey zone: A case report

Muheilan, Muheilan Mustafa; Shomaf, Maha; Tarawneh, Emad S.; Murshidi, Muayyad Mujalli; Al-Sayyed, Manar Rizik; Murshidi, Mujalli Mhailan

doi:10.1016/j.ijscr.2017.03.043

Cited by 10 publications

(14 citation statements)

References 13 publications

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“…However, the strongest indicator of malignancy is the presence of metastases (8). Malignant tumors occur exclusively in adults and are unaccompanied by endocrine changes (1,9). In our case, the tumors size was 15 mm, the patient was young, there were no vascular invasion, cytological atypia or necrosis and surgical margins were negative and no distant metastasis was found.…”

Section: Discussionmentioning

confidence: 53%

Leydig Cell Tumor of the Testis: A Case with Incidental Diagnosis

Eren¹,

Aydın²,

Aldemir³

et al. 2019

jus

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Leydig hücreli tümörler, yetişkin testis tümörlerinin yaklaşık %1-3'ünü oluşturmaktadır. Bu tümörler gonadal stromal tümörlerin en sık rastlanan türü olup, erkeklerde en yaygın 3 ile 6. dekatlarda görülürler. Leydig hücre tümörlerinin yaklaşık %10'u maligndir. Bu yazıda primer infertilite nedeniyle araştırılan bir hastada insidental tanı konan bir Leydig hücreli testis tümörü olgusu sunmaktayız. Yirmi sekiz yaşında evli bir erkek hasta primer infertilite şikayeti ile kliniğimize başvurdu ve skrotal ultrasonografi incelemesinde sol testiste heterojen ve hipoekoik bir kitlesi olduğu görüldü. Hastaya sol radikal orşiektomi uygulandı ve patoloji sonucu testis Leydig hücreli tümörü olarak raporlandı. Toraks ve batın bilgisayarlı tomografisinde uzak metastaz saptanmadı ve hasta takibe alındı. Anahtar Kelimeler: İnfertilite, Leydig hücreli tümör, Testiküler neoplaziler, İnguinal orşiektomi Leydig cell tumors account for approximately 1-3% of adult testicular tumors. These tumors are the most common type of gonadal stromal tumors and most commonly seen in the third to sixth decades of life, and about 10% of them are malignant. This case is about an incidentally diagnosed Leydig cell testis tumor in a patient who was investigated for primary infertility. A 28-year-old male patient presented with primary infertility and scrotal ultrasonography examination revealed a heterogeneous hypoechoic mass in the left testicle. He underwent left radical orchiectomy and pathological diagnosis was testicular Leydig cell tumor. There was no distant metastasis and the patient is being followed for metastasis.

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Section: Discussionmentioning

confidence: 53%

Leydig Cell Tumor of the Testis: A Case with Incidental Diagnosis

Eren¹,

Aydın²,

Aldemir³

et al. 2019

jus

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“…Clinically, LCT presents as a potentially malignant testicular mass with or without endocrine abnormalities such as loss of libido and gynecomastia. [ 1 ] There are 2 age peaks in the incidence of LCT: 30 to 60 years in adult and 3 to 9 years in child. [ 1 ] According to the review by Efthimiou et al, [ 11 ] 480 cases of LCT have been reported in the English literature and 29.2% of them are presented as testicular mass, 12.5% with gynecomastia.…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 ] There are 2 age peaks in the incidence of LCT: 30 to 60 years in adult and 3 to 9 years in child. [ 1 ] According to the review by Efthimiou et al, [ 11 ] 480 cases of LCT have been reported in the English literature and 29.2% of them are presented as testicular mass, 12.5% with gynecomastia. The mechanism of hormonal disorders is likely to be excess production of testosterone and estrogens by the tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Leydig cell tumor (LCT) is a rare testicular tumor, with malignant potential. [ 1 ] To the best of our knowledge, most LCTs are presented as case report or as small series in the English literature. About 3% cases of LCT are bilateral, [ 1 ] while 10% are malignant with metastatic forms, particular to the inguinal lymph nodes and extranodal organs, including the liver, lungs, and bones.…”

Section: Introductionmentioning

confidence: 99%

“…[ 1 ] To the best of our knowledge, most LCTs are presented as case report or as small series in the English literature. About 3% cases of LCT are bilateral, [ 1 ] while 10% are malignant with metastatic forms, particular to the inguinal lymph nodes and extranodal organs, including the liver, lungs, and bones. [ 2 ] Histologically, the tumor consists of the proliferation of large polygonal tumor cells with granular eosinophilic cytoplasms.…”

Section: Introductionmentioning

confidence: 99%

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Management of testicular Leydig cell tumor

Zhu

Luan

2018

Medicine

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Rationale:Testicular Leydig cell tumor (LCT) is a rare neoplasm. It commonly presents as a painless testicular mass with or without endocrine changes. Histological and immunohistochemical examination play important roles in differentiating LCT from testicular germ cell tumors.Patient concerns:We highlight the imaging phenotype, as well as the pathological findings of a case of LCT in a 62-year-old male.Diagnoses:Preoperative noncontrast CT scan of the abdomen revealed a 7.0 × 6.4 × 5.3 cm oval mass with heterogeneous density, located in the right testis. Pelvic noncontrast MRI showed a heterogeneous mass on T1-weighted and T2-weighted images. The solid part of the tumor exhibited high signal on the diffusion-weighted imaging, and an obvious enhancement on the contrast-enhanced MR imaging. Ultrasonography examination demonstrated a large mixed echogenic space occupying lesion involving the whole right testis with multiple cystic areas and increased vascularity. This patient underwent radical orchiectomy. The pathologic diagnosis was LCT.Interventions:This patient underwent operative resection of the tumor. Due to the negative resection margins and absence of distant metastases, the patient did not receive additional radiotherapy or chemotherapy.Outcomes:Four months after the surgery, the follow-up CT-scan did not reveal any local recurrence and distant metastases.Lessons:This case improves our ability to detect and diagnose LCT by summarizing its imaging characteristics as well as reviewing the literature. Additionally, we described the state-of-the-art management of the management of this rare tumor.

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