LGV
            <i>Chlamydia trachomatis</i>
            serotypes: an update from Milan, Italy

Benardon, Susanna; Lunghi, G.; Bono, Patrizia; Orlandi, Annarosa; Pacela, Francesca; Zoccoli, Antonella; Boeri, Enzo; Sampaolo, Michela; Cusini, Marco

doi:10.1136/sextrans-2016-052985

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…10 In the present study, unique epidemiological data regarding MSM in Russia are also presented, and our results are consistent with previous studies in other countries focusing on LGV epidemiology and proctitis among MSM. 3,[5][6][7][8]27,28 Findings such as a high prevalence of HIV and STI co-infections might be a consequence of condomless sexual intercourse with multiple partners, especially in LGV-positive MSM, who reported having significantly more sexual partners per 6 months compared to MSM having non-LGV CT in our study. 14,23 Furthermore, the LGV spread in the city among MSM might be accelerated due to socio-economic reasons: more welldeveloped economy and higher level of tolerance to Lesbian, Gay, Bisexual, Transgender, and Queer (LGBTQ) in Moscow compared to most other places of the country attract MSM from other regions.…”

Section: Discussionmentioning

confidence: 86%

“…Since 2003, when the first outbreak of LGV proctitis in MSM was documented in Western Europe, 2,19 many studies regarding similar outbreaks in additional EU/EEA countries have been published 3,5–8 and LGV is now considered as endemic among MSM in many EU/EEA countries. 1 However, no studies examining the MSM population in Russia and its prevalence of LGV have been previously performed.…”

Section: Discussionmentioning

confidence: 99%

“…1,4 LGV proctitis nearly exclusively in MSM has been reported in, for example, the United Kingdom, France, Spain, Italy, Malta, Czech Republic, and Hungary. 3,[5][6][7][8] However, no verified LGV cases in Russia have been reported, despite the high prevalence of CT in the country. 9 Also in Russia, proctologists frequently manage anorectal disorders in MSM.…”

Section: Introductionmentioning

confidence: 99%

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First reported lymphogranuloma venereum cases in Russia discovered in men who have sex with men attending proctologists

et al. 2022

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Background Several lymphogranuloma venereum (LGV) outbreaks among men who have sex with men (MSM) have been reported throughout the world since 2003. Nevertheless, no LGV cases have been internationally reported from Russia. We evaluated the prevalence of LGV among MSM attending proctologists in Moscow, Russia, and compared the LGV and non-LGV rectal Chlamydia trachomatis (CT) infections. Methods MSM ( n = 534) attending for proctologic care were included. Rectal specimens were sampled for CT and Neisseria gonorrhoeae (NG) by nucleic acid amplification tests (NAATs). All CT-positive patients were tested with an LGV-specific NAAT. Results In total, 37.3% (95% CI 33.3–41.5; 199/534) of MSM were CT positive. Of these, 68.8% (95% CI 62.1–74.9; 137/199) had LGV and 31.2% (95% CI 25.1–37.9; 62/199) a non-LGV rectal CT infection. Older age (34 years vs. 31 years, p = 0.035) and group-sex practices (67.2% (92/137) vs. 33.9% (21/62), p < 0.0001) were associated with LGV. The LGV-positive MSM were also more likely to be HIV-positive (67.2% (92/137) vs. 41.9% (26/62), p = 0.001). Proctoscopy revealed ulcerative proctitis/proctocolitis in 99.3% (136/137) of LGV-positive MSM. No ulcerative or erosive proctitis was found in the MSM with non-LGV CT infection, but 58.1% (36/62) of them had anorectal disorders. Finally, mild catarrhal or hemorrhagic proctitis was diagnosed in only 21.6% (8/37) of MSM with non-LGV CT infection lacking concomitant NG or syphilis ( p < 0.0001). Conclusions LGV is widely spread among MSM attending proctologists in Moscow. Clinically, acute LGV proctitis/proctocolitis can be difficult to distinguish from inflammatory bowel disease that leads to mismanaged LGV infections. LGV diagnostic laboratory testing is essential, however, currently mainly lacking for MSM in Russia. All MSM with CT-positive rectal specimens should be subsequently tested for LGV.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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First reported lymphogranuloma venereum cases in Russia discovered in men who have sex with men attending proctologists

et al. 2022

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Sexually transmitted rectal infections in a cohort of ‘men having sex with men’

Foschi

Gaspari

Sgubbi

et al. 2018

Journal of Medical Microbiology

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Lymphogranuloma venereum genovariants in men having sex with men in Italy

Marangoni

Foschi

Tartari³

et al. 2020

Sex Transm Infect

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ObjectivesLymphogranuloma venereum (LGV) is an STI caused by Chlamydia trachomatis serovars L1-L3. In Europe, the current epidemic is caused mainly by L2b genovariant, although increasing cases associated with other L2 variants have been reported. Here, we assessed the distribution of rectal LGV genovariants among men having sex with men (MSM) in Italy.MethodsFrom 2016 to 2020, all the anorectal swabs collected from MSM attending the STI Clinic of St. Orsola-Malpighi Hospital in Bologna and positive for C. trachomatis were stored. LGV infection was confirmed by a pmpH PCR, and, subsequently, a fragment of the ompA gene was amplified and sequenced. Sequences were aligned to reference strains representing different LGV variants.ResultsLGV cases accounted for one-third of all chlamydial rectal infections with a total prevalence of 4.1% (76/1852). Total number of LGV cases per year remained constant. LGV was mainly found in symptomatic patients (>65%), older than 30 years, with a high burden of other STIs (63.7% HIV-positive, 35.5% with concurrent rectal gonorrhoea, 19.7% with early syphilis). A decreasing trend in HIV-LGV co-infection was noticed over time. Three main LGV genovariants were detected (L2f, 46.1%; L2b, 23.0%; L2-L2b/D-Da, 16.9%), together with other known L2b variants (mainly L2bV2 and L2bV4). Two novel L2b ompA variants with non-synonymous single-nucleotide polymorphisms were found. Over time, the percentage of L2f cases dropped gradually, with a significant increase in L2-L2b/D-Da cases (p=0.04).ConclusionsIn our area, LGV is endemic among MSM with different circulating genovariants. Active surveillance and genotyping programmes are needed to reduce re-establishing of LGV infection.

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LGV Chlamydia trachomatis serotypes: an update from Milan, Italy

Cited by 3 publications

References 2 publications

First reported lymphogranuloma venereum cases in Russia discovered in men who have sex with men attending proctologists

First reported lymphogranuloma venereum cases in Russia discovered in men who have sex with men attending proctologists

Sexually transmitted rectal infections in a cohort of ‘men having sex with men’

Lymphogranuloma venereum genovariants in men having sex with men in Italy

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