Lh and FSH in Serum After Intramuscular Administration of Lh/FSH-Releasing Hormone in Normal and Hypogonadal Men

Abstract

The increase in serum concentrations of LH and FSH after intramuscular administration of LH/FSH-RH was investigated in normal and hypogonadotrophic hypogonadal males. LH and FSH were measured by specific radio-immunoassays. To evaluate the appropriate dose of LH/ FSH-RH for intramuscular administration different doses were administered and with 200 μg an increase in LH and FSH was found comparable to the results obtained by other investigators using intravenous administration. After the initial studies a simple test including two determinations before LH/FSH-RH administration and one 60 min and 120 min after administration was developed and used in all cases. In 12 normal males a significant increase in the serum concentration of both LH and FSH was found averaging 381 % and 148 % respectively 60 min after 200 μg LH/FSH-RH with a slight decrease in LH but not in FSH after 120 min. A positive response similar to that in normal men was observed in 11 hypogonadotrophic hypogonadal patients presenting different clinical pictures. This indicates that in all these patients the hypogonadotrophic state was due to a hypothalamic defect and not to a hypophyseal disorder.

Rise in Dehydroepiandrosterone and Oestrogens During Clomiphene Administration in Normal Men

“…The serum concentration of both hormones are significantly greater after 14 days of treatment than after 8 days. Although not significantly different we find a tendency to a greater response in LH than in FSH which is in accordance with the results obtained with LH/FSH-RH stimulation of the pituitary gland (Jorgensen et al 1975). …”

The Effect of Repeated intramuscular Gonadotrophin‐Releasing Hormone Injections on Luteinizing Hormone, Follicle‐Stimulating Hormone, Testosterone, Oestrogens, Dehydroepiandrosterone and Dehydro‐epiandrosterone Sulfate in Normal Men

“…In males the oestrogens are derived mostly by peripheral conversion of testosterone (12). The significant correlation found in the present study (8).…”

“…In addition to be of potential diagnostic value the gonadotrophin releasing hormone, LH-RH, has also proved to be useful therapeutically in hypogonadal males with hypothalamic dysfunction (2, 8). Mortimer et al (13) demonstrated that 500 Ltg LH-RH administrated subcutaneously three times a day to 12 hypogonadal males increased significantly the serum concentration of LH, FSH, testosterone and dihydrotestosterone.…”