LI Papilloma of the Larynx: A Review of 109 Cases with a Preliminary Report of Aureomycin Therapy

Neoplasia and Internal Environment

“…Zalin (1948) had two successes with this therapy, whereas Gorrell (1952) was unable to influence the growth. That endocrine factors can influence the course of papillomatosis is clearly demonstrated by a case recorded by Holinger, Johnston and Anison (1950). The patient, a young woman, had undergone sixty-three endoscopic procedures for removal of recurrent laryngeal papillomas in thirteen years.…”

Failure of Gamma Interferon but Not Interleukin-10 Expression in Response to Human Papillomavirus Type 11 E6 Protein in Respiratory Papillomatosis

“…Human papillomavirus type 6 (HPV-6) and HPV-11 are the predominant HPV viruses that cause papilloma development (21,33), and it is unclear why only a very small faction (4 to 6/100,000) of HPV-6-and HPV-11-exposed individuals develop this disease (4). Furthermore, it is unknown why a still smaller group of individuals has a severe and unrelenting course of disease that can cause significant morbidity, and on occasion mortality, because of the strategic location of papillomas in the airway (2,24). There is clinical variability between patients and, on occasion within a given patient (2,9,24,48).…”

“…Furthermore, it is unknown why a still smaller group of individuals has a severe and unrelenting course of disease that can cause significant morbidity, and on occasion mortality, because of the strategic location of papillomas in the airway (2,24). There is clinical variability between patients and, on occasion within a given patient (2,9,24,48). However, the immunologic mechanism(s) that govern this variation in disease severity and predisposes only a small group of HPV-exposed individuals to develop recurrent respiratory papillomatosis (RRP) are unresolved.…”

“…However, the immunologic mechanism(s) that govern this variation in disease severity and predisposes only a small group of HPV-exposed individuals to develop recurrent respiratory papillomatosis (RRP) are unresolved. Some patients may require as many as 200 surgical procedures to maintain a patent airway (2,24), and a small group of patients with RRP may progress to a more serious extension of their disease into the trachea and lungs (54). In contrast, some patients may show no signs of disease recurrence after their first clinical presentation.…”

Invasive Multiple Supraglottic Squamous Cell Papillary Carcinoma in an Adult

“…Jackson and Jackson, cited by Altman et al [2], observed such changes in 6 of 205 patients and Cunning [3] in 38 of 276. Holinger et al [4] studied 55 adults with sin gle (35 patients) or multiple (20 patients) papilloma of the larynx and none showed evidence of malignancy. Altman et al [2] reported anaplastic changes in 11 of 51 adult patients: 38 had a single papilloma and 13 had multiple tumors.…”