Lianhua Qingwen prescription for Coronavirus disease 2019 (COVID-19) treatment: Advances and prospects

Li, Liu-Cheng; Zhang, Zhihui; Zhou, Wencheng; Chen, Jie; Jin, Hong; Fang, Hua; Chen, Qin; Jin, Yi; Qu, Jiao; Kan, Lian‐Di

doi:10.1016/j.biopha.2020.110641

Cited by 50 publications

(35 citation statements)

References 33 publications

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“…However, no interaction was highlighted with the active site of the HCV helicase (Kaneez et al 2014). In SARS-CoV-2 context, Lianhua Qingwen Capsule (LQC) showed some therapeutic effects on Covid-19 patients (Li et al 2020). In view to understand the molecular mechanism of such activity, docking analysis has been executed with Autodock Vina (Xia et al 2020).…”

Section: Discussionmentioning

confidence: 99%

Docking and in silico toxicity assessment of Arthrospira compounds as potential antiviral agents against SARS-CoV-2

Petit¹,

Vernès²,

Cadoret³

2021

J Appl Phycol

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A race is currently being launched as a result of the international health situation. This race aims to find, by various means, weapons to counter the Covid-19 pandemic now widespread on all continents. The aquatic world and in particular that of photosynthetic organisms is regularly highlighted but paradoxically little exploited in view of the tremendous possibilities it offers. Computational tools allow not only to clear the existence and activity of many molecules but also to model their relationships with receptors identified in potential hosts. On a routine basis, our laboratory carries out a research activity on functionalities of molecules derived from algae using in silico tools. We have implemented our skills in algae biology and in modeling, as tests in order to identify molecules expressed by the genus Arthrospira showing an antiviral potential and more particularly anti-SARS-CoV-2. Using consensus docking and redocking with Autodock Vina and SwissDock, we were able to identify several promising molecules from Arthrospira: phycocyanobilin, phycoerythrobilin, phycourobilin, and folic acid. These four compounds showed reliable binding energies comprised between − 6.95 and − 7.45 kcal.mol −1 in Autodock Vina and between − 9.285 and − 10.35 kcal.mol −1 with SwissDock. Toxicity prediction as well as current regulations provided promising arguments for the inclusion of these compounds in further studies to assess their ability to compete with the SARS-CoV-2/ACE2 complex both in vitro and in vivo.

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Section: Discussionmentioning

confidence: 99%

Docking and in silico toxicity assessment of Arthrospira compounds as potential antiviral agents against SARS-CoV-2

Petit¹,

Vernès²,

Cadoret³

2021

J Appl Phycol

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“…LH capsules have re-attracted attention due to their effectiveness against COVID-19; specifically, these capsules can inhibit SARS-COV-2 replication and regulate the secretion of inflammatory cytokines( Li et al, 2020b ). Experiments using chicken embryos and cytotoxicity assays have shown that LH capsules are safe, and modern pharmacological studies have demonstrated that LH capsules exert a good inhibitory effect on influenza A virus (IAV) and influenza B virus (IBV)( Ding et al, 2017 ; Zhao et al, 2014 ).…”

Section: Safety and Effectiveness Of Lh Capsulesmentioning

confidence: 99%

Insights into forsythia honeysuckle (Lianhuaqingwen) capsules: A Chinese herbal medicine repurposed for COVID-19 pandemic

et al. 2021

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“…[ 11 ] Chinese herbal injections were recommended for the treatment of COVID-19 after the outbreak of COVID-19 officially in China. [ 86 ] Up to now, cumulative clinical research progress has demonstrated the synergistic benefits of Chinese herbal injections in combination with Western medicine on reducing the time of SARS-CoV-2 RNA clearance, increasing the improvement rate of chest CT manifestations, as well as improving multiple other clinical outcomes ( Table 2 ). The pharmacological mechanisms mainly attributed to the antiviral activity, regulation of immunity, and inhibition of inflammatory storm.…”

Section: Future Perspectives and Concluding Remarksmentioning

confidence: 99%

Chinese herbal injections for coronavirus disease 2019 (COVID-19): A narrative review

Zhu

Guo

Zhang

et al. 2021

Integrative Medicine Research

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Background The outbreak of Coronavirus disease 2019 (COVID-19) has caused more than 180 million infections and 3.9 million deaths. To date, emerging clinical evidence has shown the synergetic benefits of Chinese herbal injections in treating this contagious respiratory disease. This review aims to summarize and analyze the efficacy and safety of Chinese herbal injections in the therapy of COVID-19. Methods The literature from 3 electronic databases, PubMed, CNKI, and Web of Science, were searched using the search terms “COVID-19”, “SARS-CoV-2”, “traditional Chinese medicine”, “herb”, “herbal”, and “injection”. Then the identified articles were comprehensively evaluated. Results Limited data demonstrated that Chinese herbal injections could significantly improve the clinical outcomes of COVID-19 patients, especially in combination with conventional treatment strategies. The benefits of which were mainly associated with the relief of symptoms, prevention of secondary infection, regulation of inflammation and immune function. There was also evidence showing the inhibitory effects on SARS-CoV-2 replication in vitro. Nevertheless, available real-world data suggested the increased risk of adverse event. Furthermore, the defects of existing researches and the insights for discovering novel antiviral drugs were prospectively discussed. Conclusion Evidence-based advances revealed that Chinese herbal injections such as XueBiJing injection and ShenMai injection, exerted potent effects against COVID-19. Further laboratory researches and clinical evaluation are needed to gather scientific evidence on the efficacy and safety.

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Lianhua Qingwen prescription for Coronavirus disease 2019 (COVID-19) treatment: Advances and prospects

Abstract: Graphical abstract

Cited by 50 publications

References 33 publications

Docking and in silico toxicity assessment of Arthrospira compounds as potential antiviral agents against SARS-CoV-2

Docking and in silico toxicity assessment of Arthrospira compounds as potential antiviral agents against SARS-CoV-2

Insights into forsythia honeysuckle (Lianhuaqingwen) capsules: A Chinese herbal medicine repurposed for COVID-19 pandemic

Chinese herbal injections for coronavirus disease 2019 (COVID-19): A narrative review

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