Liaoning Score for Prediction of Esophageal Varices in Cirrhotic Patients Who Had Never Undergone Endoscopy: A Multicenter Cross-Sectional Study in Liaoning Province, China

Qi, Xingshun; Li, Yiling; Wang, Ran; Lin, Lie‐Chwen; Li, Jing; Wang, Lijun; Zheng, Shuang; Sun, Yan; Zhao, Lei; Fu, Xiaolin; Wang, Mengchun; Qiu, Xinping; Deng, Han; Hong, Cen; Li, Qianqian; Li, Hongyu; Guo, Xiaozhong

doi:10.1007/s12325-019-00967-w

Cited by 19 publications

(16 citation statements)

References 24 publications

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“…This was close to the results of Qi et al ., 15 who showed that the best cut‐off value for the Liaoning score was >0.474, with a sensitivity of 70%, a specificity of 77.67%, a PPV of 88.8%, and an NPV of 50.6%.…”

Section: Discussionsupporting

confidence: 90%

“… AST to platelets ratio index (APRI) = [(AST/ULN) × 100]/platelet count 109/L (ULN = the upper limit of normal) 13 ; King score = Age × AST × INR/Platelets 14 Lok score: log odds = −5.56 – 0.0089 × platelet count (103/mm3) + 1.26 × (AST/ALT) + 5.27 × INR; Lok = [exp (log odds)]/[1 + exp (log odds)] 15 FIB‐4 = (Age × AST)/(Platelets × √ (ALT)) 14 …”

Section: Methodsmentioning

confidence: 99%

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Accuracy of noninvasive tests in the prediction of portal hypertensive gastropathy in Egyptian patients with cirrhosis

et al. 2021

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Background and AimLiver cirrhosis (LC) is commonly associated with portal hypertensive gastropathy (PHG), and it causes gastrointestinal (GI) bleeding. Esophagogastroduodenoscopy (EGD) is the gold standard in diagnosing PHG. Besides its invasiveness, the disadvantages of EGD include psychological and financial problems. We aimed to evaluate the diagnostic accuracy of different noninvasive screening tools in predicting PHG.MethodsThis cross‐sectional study was conducted on 100 patients with LC who were divided into two groups based on EGD: group (A), 50 patients with LC with PHG, and group (B), 50 patients with LC without PHG. All patients were subjected to history taking, full clinical examination, laboratory investigations, abdominal–pelvic ultrasonography, and EGD.ResultsTo predict PHG, the respective sensitivity and specificity of portal vein diameter (>10.5 mm) were 86 and 67%, of gallbladder wall thickness (GBWT) (>3.5 mm) were 64 and 68%, of platelets/GBWT (<40) were 68 and 78%, of aspartate aminotransferase (AST)/platelet ratio index (APRI) score (>1.1) were 60 and 66%, of platelet/spleen diameter (<1290) were 88 and 72%, of right liver lobe diameter/albumin ratio (>4) were 74 and 80%, and of AST/alanine aminotransferase (ALT) ratio (>1.1) were 50 and 58% (P = 0.353).ConclusionPortal vein diameter, platelet/spleen diameter, and right liver lobe diameter/albumin ratio were independently associated with PHG and were good predictors of the PHG, whereas AST/ALT ratio and King score are poor predictors.

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Section: Discussionsupporting

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Accuracy of noninvasive tests in the prediction of portal hypertensive gastropathy in Egyptian patients with cirrhosis

et al. 2021

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“…The first survey devoted to Liaoning score proved that ascites and PLTs in the course of LC are independent predictors for EVs in patients with AUGIB. However, in the group without AUGIB, PLTs were shown to be the single predictor for EVs [34]. Consequently, the study by Qianqian et al on cirrhotic patients revealed that AUC of Liaoning score for predicting EVs was greater compared to APRI, AAR, and FIB-4 (0.737 vs. 0.650, 0.626, and 0.709, respectively) [35].…”

Section: Discussionmentioning

confidence: 99%

Plateletcrit and Mean Platelet Volume in the Evaluation of Alcoholic Liver Cirrhosis and Nonalcoholic Fatty Liver Disease Patients

Michalak

Cichoż‐Lach

Guz

et al. 2021

BioMed Research International

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Platelet (PLT) indices have been proposed as potential markers in the assessment of liver fibrosis and exacerbation of liver failure. The aim of our study was to verify mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) in alcohol-related liver cirrhosis (ALC) and nonalcoholic fatty liver disease (NAFLD) patients. One hundred forty-two patients with ALC, 92 with NAFLD, and 68 in control group were enrolled in this study. Hematological indices (MPV, PCT, and PDW) and serological (indirect and direct) markers of liver fibrosis (AAR, APRI, FIB-4, GPR, PICP, PIIINP, TGF-α, PDGF-AB, laminin) were measured in each participant. MELD score in ALC patients and NAFLD fibrosis score (NFS) together with BARD score in the NAFLD group were also obtained. Results were compared between research and control groups. Then, a correlation between evaluated indices was performed in study groups. Receiver operating characteristic curves (ROCs) and area under the curve (AUC) values were applied to assess the diagnostic accuracy of measured indices. Significant increase in PDW and decrease in PCT in comparison to controls were noted in examined ALC (60.4% vs. 51.2% and 0.1% vs. 0.21%, respectively, p < 0.0001 ) and NAFLD (54.75% vs. 51.2% and 0.19 vs. 0.21%, respectively, p < 0.01 ) patients. Decreased level of MPV was observed in NAFLD group (7.85 fl vs. 8.90 fl, p < 0.0001 ). Additionally, PCT correlated with NFS ( p < 0.0001 ). Evaluated PLT indices correlated with MELD score (MPV and PDW, p < 0.001 ; PCT, p < 0.05 ). They correlated with indirect and direct markers of liver fibrosis in the whole research group, too. PCT was the parameter with the greatest diagnostic accuracy in ALC patients ( AUC = 0,839 for cutoff < 0.17 % ); in NAFLD group, it was MPV ( AUC = 0,808 for cutoff < 7.9 fl ). PCT in ALC and MPV in NAFLD can be perceived as potential diagnostic markers.

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“…Regarding the performance of platelet values for predicting the presence and severity of EV, the results are controversial. Even if some studies demonstrated a good performance of platelet count alone to predict the presence and severity of EV, most studies have shown that their performance is better when used along with other non-invasive markers [ 4 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Assessing Baveno VI Criteria Using Liver Stiffness Measured with a 2D-Shear Wave Elastography Technique

et al. 2021

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The present study evaluates the performance of Baveno VI criteria, using liver stiffness (LS) assessed with a 2D-SWE elastography technique, for predicting high-risk varices (HRV) in patients with compensated advanced chronic liver disease (cACLD). A secondary aim was to determine whether the use of spleen stiffness measurements (SSMs), as additional criteria, increases the performance of the 2D-SWE Baveno VI criteria. Data were collected from 208 subjects with cACLD, who underwent abdominal ultrasound, liver and spleen stiffness measurements, and upper digestive endoscopy. HRV were defined as grade 1 esophageal varices (EV) with red wale marks, grade 2/3 EV, and gastric varices. A total of 35.6% (74/208) of the included subjects had HRV. The optimal LS cut-off value for predicting HRV was 12 kPa (AUROC-0.80). Using both LS cut-off value < 12 kPa and a platelet cut-off value > 150 × 109 cells/L as criteria to exclude HRV, 52/208 (25%) subjects were selected, 88.5% (46/52) were without EV, 9.6% (5/52) had grade 1 EV, and 1.9% (1/52) had HRV. Thus 98% of the subjects were correctly classified as having or not having HRV and 25% of the surveillance endoscopies could have been avoided. Using SS < 13.2 kPa and a platelet cut-off value > 150 × 109 cells/L as additional criteria for the patients that were outside the initial ones, 32.7% of the surveillance endoscopies could have been avoided.

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Liaoning Score for Prediction of Esophageal Varices in Cirrhotic Patients Who Had Never Undergone Endoscopy: A Multicenter Cross-Sectional Study in Liaoning Province, China

Cited by 19 publications

References 24 publications

Accuracy of noninvasive tests in the prediction of portal hypertensive gastropathy in Egyptian patients with cirrhosis

Accuracy of noninvasive tests in the prediction of portal hypertensive gastropathy in Egyptian patients with cirrhosis

Plateletcrit and Mean Platelet Volume in the Evaluation of Alcoholic Liver Cirrhosis and Nonalcoholic Fatty Liver Disease Patients

Assessing Baveno VI Criteria Using Liver Stiffness Measured with a 2D-Shear Wave Elastography Technique

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