Liberation of Catecholamines From Blood Platelets

Pletscher, A.

doi:10.1111/j.1476-5381.1981.tb09134.x

Cited by 14 publications

(1 citation statement)

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“…However, understanding of the mechanisms responsible for IP synthesis, breakdown, and regulation in schizophrenia in NL-treated and untreated patients is still very rudimentary. It is intriguing to consider that platelets are comparable to catecholaminergic neurons (12) and as such they may represent an acceptable model of a neurosecretory cell to investigate membrane-dependent functions such as signal transduction in schizophrenic disorders (10). Thrombin is a potent agonist leading to the activation of phospholipases C and A2, protein kinases, IP, and Ca 2ϩ mobilization.…”

Section: Discussionmentioning

confidence: 99%

Neuroleptic Malignant Syndrome and Severe Thrombocytopenia: Case Report and Literature Review

Ghani¹,

Ahmed²,

Marco³

2000

Ann. of Clinical Psychiatry

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We report an unusual case of thrombocytopenia associated with neuroleptic malignant syndrome (NMS). A 31-year-old Black male with a history of hypertension, partial seizures, and schizophrenia developed acute rigidity closely followed by severe hyperpyrexia (temperature 102ЊF), tachypnea, and tachycardia. His home medications at the time of presentation included propanolol 10 mg tid, haloperidol 10 mg bid, sodium valproate 500 mg bid, benztropine 1 mg bid, and haloperidol decanoate 100 mg i.m. every 3 weeks, from another psychiatric facility. Despite vigorous therapy for the hyperthermia, he rapidly developed significant hypoxia requiring mechanical ventilation. A diagnosis of neuroleptic malignant syndrome was made and the patient continued to receive aggressive supportive care. On hospital day 2 his platelet count dropped to 47,000/Ȑl and bottomed out at 36,000/Ȑl by day 3 with other blood cell counts remaining within normal limits. Over the next few days he showed rapid clinical improvement with normalization of his blood chemistries and he was discharged home after 5 days of hospitalization in good condition.

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Section: Discussionmentioning

confidence: 99%