2008
DOI: 10.1002/ejic.200800139
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Libraries of Bidentate Phosphorus Ligands; Synthesis Strategies and Application in Catalysis

Abstract: Combinatorial chemistry in combination with high‐throughput screening technologies is an important way of finding new successful catalyst systems. The design of ligand libraries of bidentate phosphorus ligands and the application of their transition‐metal complexes in homogeneous (asymmetric) catalysis reactions will be described in this review. Till now three different approaches were developed to arrive at such libraries of bidentate phosphorus ligands: 1) modular synthesis of bidentate ligands 2) the solid … Show more

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Cited by 104 publications
(37 citation statements)
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“…For these challenging reactions, the trial-and-error approach is still dominant in the search for appropriate catalysts, and thus, combinatorial methods and high-throughput screening of ligands and catalysts have been developed. [2] Supramolecular ligands that form by selfassembly of smaller components appear suitable for this approach, as the modular synthesis efficiently generates wide libraries of ligands. [3] Enzyme mimicry represents an alternative route to selective catalysts.…”
mentioning
confidence: 99%
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“…For these challenging reactions, the trial-and-error approach is still dominant in the search for appropriate catalysts, and thus, combinatorial methods and high-throughput screening of ligands and catalysts have been developed. [2] Supramolecular ligands that form by selfassembly of smaller components appear suitable for this approach, as the modular synthesis efficiently generates wide libraries of ligands. [3] Enzyme mimicry represents an alternative route to selective catalysts.…”
mentioning
confidence: 99%
“…In the absence of a phosphorus ligand, substrate 5 is hydroformylated with poor selectivity (l/b = 1.8) and low convrsion (Table 1, entry 4). Importantly, for non-anionic substrates, the addition of excess acetate ion that binds in the DIM pocket of [Rh(1)(CO) 2 H] has no effect on the (low) regioselectivity. [17] The substrates that are longer than the one that precisely fits between the metal and the binding site-5-hexenoate through 8-nonenoate anion-also experience an effect of binding in the DIM pocket.…”
mentioning
confidence: 99%
“…For asymmetric catalysis, however, catalyst optimization relies to a large extent on trial and error, hence the combinatorial screening of libraries of chiral catalysts is a frequently applied strategy. [1] Besides catalyst screening, attempts toward the rational design of chiral catalysts have also been made, which generally lead to strategies for ligand development. [2] The asymmetric hydrogenation reaction is among the classic success stories in this respect since it has resulted in several scientific breakthroughs, [3] as well as the development of commercial processes.…”
mentioning
confidence: 99%
“…Systems based on bidentate phosphorus ligands have been shown to be highly successful in asymmetric transition-metal catalysis [18,19], but efficient combinatorial methodologies to facilitate the synthesis and screening of vast libraries of these type of ligands are still lacking. This is mainly due to laborious (and low yielding) work-up procedures of these type of compounds and their sensitivity towards moisture and air [20].…”
Section: Introductionmentioning
confidence: 99%