It is not feasible for a library to hold or acquire a full collection of information resources which may be required by its patrons. To deal with this issue, library cooperation was adopted, for instance, interlibrary loaning, document delivery and library network, formed to build the acquiring capacity of cooperating institutions to grow the accessibility of information resources and offer computerized services. In Kenya, there is KLISC which has carried out commendable activities to support research in Kenya. KLISC has done admirable exercises to support research in Kenya. These exercises incorporate collaborative acquisition of information resources, ICT training of information experts and the preparation of researchers to improve their abilities in retrieving information. Despite the activities and services that KLISC provide, its resources are yet to be appreciated by a majority of the users of the member institutions. Also, not all information providers and institutions of higher learning are members. Kenya has over 600 institutions but only 112 are KLISC members as of 2018 and the numbers keep reducing. The study therefore tried to identify the challenges that the KLISC members face that could be affecting utilization of the electronic resources, members pulling out and also discouraging other institutions from joining. The study found out that KLISC members experienced the following challenges; slow internet connectivity, information illiteracy, lack of searching skills, low awareness levels, slow downloading speed, unfriendly platforms, password requirements for some databases, poor ICT infrastructure, poor ICT skills for both users and staff, delays in releasing of funds by the management, and slow communication from the publishers. KLISC itself faces the following challenges: members do not efficiently communicate about their information needs, lack of sponsorship since INASP pulled out, delay by KLISC’s members to pay their annual subscription fee, and the management team is overwhelmed by work. The study therefore recommended the following: Institutions should invest more on ICT infrastructure, KLISC should come up with a way of ensuring relevancy, KLISC should stand on its own as an institution and acquire its own offices and employ staff who will just be working for KLISC, KLISC should create a mini-consortium to cater for research institutions and also other specialized fields in different institutions in Kenya, KLISC should come up with a way of dealing with individual defaulters in a way that does not affect the other members, the publishers should improve the interfaces of their databases to make them user friendly and easy to navigate, and the publishers should also ensure fast communications with the institutions.