Lichen Myxedematosus Serum Stimulates Human Skin Fibroblast Proliferation

Harper, Robert A.; Rispler, Jacob

doi:10.1126/science.622555

Cited by 150 publications

(71 citation statements)

References 8 publications

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“…A benign monoclonal gammopathy is usually present and the patients show discrete lichenoid papules, which can be confluent or generalized [29]. Serum from these patients can stimulate proliferation in cultured fibroblasts [30]. Fibroblasts from the lesions produce more glycosaminoglycans and the ratio of HYA to sulphated glycosaminoglycans is increased [31].…”

Section: Lichen Myxoedematosusmentioning

confidence: 99%

Hyaluronan in skin

Juhlin¹

1997

Journal of Internal Medicine

121

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Abstract. Juhlin L (University Hospital, Uppsala, Sweden). Hyaluronan in skin (Minisymposium: Hyaluronan) J Intern Med 1997; 242: 61-6.Because of the abundance of hyaluronan in skin, interest was early focused on variation in the content of the polysaccharide in various pathological conditions of this tissue. A large amount of early work utilized histological techniques of insufficient specificity but recent developments of specific analytical and staining methods for hyaluronan have supplied new data on its presence and possible role in skin disorders.

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Section: Lichen Myxoedematosusmentioning

confidence: 99%

Hyaluronan in skin

Juhlin¹

1997

Journal of Internal Medicine

121

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“…A serum factor which is distinct from the abnormal globulin and which stimulates proliferation of fibroblasts in tissue culture has been demonstrated. 8 Reticular erythematous mucinosis may represent still another variant of lichen myxedematosus, but it is not associated with any serum protein abnormality. l 6 The lesions occur on the chest and back, and appear as irregular, reticulated, erythematous macules and occasional papules.…”

Section: Review Of the Mucinoses Of Humans And Animalsmentioning

confidence: 99%

Focal Mucinosis in Dogs: Seven Cases and Review of Cutaneous Mucinoses of Man and Animals

Dillberger

Altman

1986

Vet Pathol

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Abstract. Seven dogs had one or more asymptomatic nodules, papules, or plaques on the skin or oral mucosa. The primary histologic feature was the accumulation of excess much within the dermis or submucosa. Based upon the clinical presentation and the histopathologic changes, it was proposed that these lesions represent the canine analogue of focal mucinosis in man, and that the same name be applied to the lesion in dogs. The criteria for the diagnosis of focal mucinosis were: (1) the presence of a single (rarely multiple) papule, nodule, or plaque which may be firm, rubbery, or soft, (2) the accumulation of mucin which disrupts and separates collagen fibers, (3) mild to extensive fibroblast proliferation, and (4) a mild mononuclear cell infiltration. The mucinoses of man and animals were reviewed.The dermis consists of collagen fibers, elastic fibers, vessels, and skin appendages embedded in an acid mucopolysaccharide protein complex called dermal mucin or dermal ground substance. The most prevalent mucopolysaccharide in the dermis is hyaluronic acid. The accumulation of excessive amounts of ground substance within the dermis has been termed mucinous degeneration, myxedema, or cutaneous mucinosis. The mucin accumulation may be classified as localized or generalized and primary or secondary. This report described seven cases of localized mucinosis in dogs (Table 1) and reviews the cutaneous mucinoses of humans and animals. Based on the clinical presentation and the gross and microscopic characteristics of the lesions, these cases appear to represent the canine analogue of focal mucinosis in man. Materials and MethodsThe biopsy material is derived from cases submitted to a veterinary diagnostic laboratory over a 14-month period. Case histories and follow-up information were obtained from the practitioner. All tissues were submitted in 10% neutral buffered formalin. At the laboratory they were embedded in paraffin, sectioned at 6 pm, and stained with hematoxylin and eosin. After initial examination additional sections were stained with either giemsa or toluidine blue, and alcian blue at pH 7.0, for the demonstration of acid mucopolysaccharides. Sections of each lesion were also pretreated with hyaluronidase and stained with alcian blue. Results Case 1A 10-month-old female Shar pei was presented with a skin lesion that had developed over the previous week on the lateral aspect of the left tarsus. Examination revealed an oblong raised plaque measuring 3.0 cm in greatest dimension. It had an indurated surface and was rubbery and non-painful on palpation. An excisional biopsy was performed.Microscopically, the epidermis was of normal thickness and exhibited both superficial and follicular hyperkeratosis. The dermis contained excessive amounts of mucin separating collagen fibers accompanied by a mild proliferation of stellate and spindle-shaped fibroblasts and a diffuse mild infiltration of eosinophils, plasma cells, and mast cells (Fig. 1). There was a perifollicular infiltration of eosinophils, histiocytes, and plasma...

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“…16 It was shown that serum of scleromyxedema patients with a monoclonal gammopathy stimulated the production of hyaluronic acid and prostaglandin E in fibroblast cultures but that isolated serum IgG failed to do so. 11,19 This suggests a pathogenetic role of other, yet-unknown circulating factors, such as interleukin 1, tumor necrosis factors, and transforming growth factor b, which are known to stimulate glycosaminoglycan synthesis. 16 Clinical remission of scleromyxedema after transplantation of autologous stem cells points to the bone marrow as a source of these circulating factors.…”

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confidence: 99%

Scleromyxedema-like Syndrome With Systemic Involvement in a Cat

et al. 2010

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Scleromyxedema-the generalized form of lichen myxedematosus, a primary mucinosis-is a rare disease in human patients. It is characterized by dermal mucin deposits, increased numbers of fibroblasts, and variable fibrosis in the absence of thyroid disease. It is accompanied in 80% of cases by a monoclonal gammopathy. To date, scleromyxedema with systemic involvement has not been documented in domestic animals. This is the first report of a scleromyxedema-like syndrome in a cat, which had a substantial deposition of mucin in the dermis of the head and paws with a mild gammaglobulinemia of 2.25 g/dl (reference range, 1.39-2.22 g/dl). At necropsy, multiple nodules of connective tissue intermingled with mucin deposits were conspicuous on the surface of thoracic and abdominal organs. Such severe systemic accumulations of mucin have not been reported in human or veterinary medicine.

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Lichen Myxedematosus Serum Stimulates Human Skin Fibroblast Proliferation

Cited by 150 publications

References 8 publications

Hyaluronan in skin

Hyaluronan in skin

Focal Mucinosis in Dogs: Seven Cases and Review of Cutaneous Mucinoses of Man and Animals

Scleromyxedema-like Syndrome With Systemic Involvement in a Cat

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