Lichen myxoedematosus associated with human immunodeficiency virus infection - report of two cases and review of the literature

Aunon, J. D. Dominguez; Llorente, C. Postigo; Martin, R. Llamas; Ríos, Fernando López; Tàpia, Aurora Guerra; Diez, L. Iglesias

doi:10.1046/j.1365-2230.1997.2840688.x

Cited by 11 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Kikuchi disease, oral steroid or antibiotic treatment does not influence the course of the disease, which improves spontaneously in a few months. 12 In our case, on account of the association of Still disease, oral steroid therapy was given. (EBA) serum.…”

Section: Discussionmentioning

confidence: 84%

“…Recently, the defect in β4 integrin was reported by immunofluorescence (IF) and molecular genetic studies. [3][4][5][6][7][8][9][10][11][12] Integrins are heterodimeric transmembrane glycoproteins which are engaged in adhesion, migration, and differentiation. They consist of noncovalently linked α and Multiple bullae are seen on the trunk, shoulder, and areas exposed to pressure and minor trauma.…”

Section: Discussionmentioning

confidence: 99%

“…11 Recently, several cases of human immunodeficiency virus (HIV)-infected patients with papular mucinosis have been reported; all corresponded to this discrete papular form. [12][13][14][15][16] Naeyaert et al 17 consider several subtypes within this discrete papular form: (i) acral persistent papular mucinosis; (ii) annular lesions; and (iii) other less characteristic forms.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Kikuchi disease associated with Still disease

et al. 1999

View full text Add to dashboard Cite

A 32‐year‐old white man with no previous medical past was admitted to our department with an 8‐month intermittent history of acute spiking fever with axillary, inguinal, and neck lymphadenopathy, arthritis, and cutaneous eruption. Cutaneous examination showed nonpruriginous, indurated erythematous papules affecting the face, ears, and trunk, suggestive of subacute lupus erythematosus ( Fig. 1a,b). On general physical examination, no abnormalities were observed except for arthritis of the right ankle and, a few months later, arthritis of the left knee. Biological investigations revealed a raised erythrocyte sedimentation rate with a serum ferritin level at 800 ng/mL (normal < 200 ng/mL), a white blood cell count of 12,500/mm3 (with 80% neutrophils, 16% lymphocytes, and 4% monocytes), a hematocrit of 40%, and a hemoglobin level of 13.1 g/dL. Electrolytes and liver function tests were normal. Antinuclear antibodies and antibodies to deoxyribonucleic acid (DNA) were negative. Rheumatoid factor was absent. No evidence of the following infections/organisms was found on serologic screening: syphilis, Streptococcus, Toxoplasma, Mycoplasma, Brucella, Borrelia burgdorgferi, spotted fever, leptospirosis, hepatitis B and C virus, parvovirus, human immunodeficiency virus (HIV) 1 and 2, human T‐cell lymphotropic virus (HTLV) 1, Epstein–Barr virus (EBV), cytomegalovirus (CMV), herpes simplex virus (HSV) 6. Immunoglobulin M (IgM) HSV(1+2) by enzyme‐linked immunosorbent assay (ELISA) analysis with 1 year follow‐up was still detected. The articular synovial fluid of the involved ankle and knee was inflammatory but sterile. A bone marrow biopsy specimen revealed no lymphomatous involvement. Abdominal and chest scans were normal. Skin biopsy of a facial nodule showed, in the dermis and in the subcutaneous fat tissue, a dense perivascular and periadnexal infiltrate composed of numerous plasmacytoid histiocytes and large‐ or medium‐sized lymphocytes ( Fig. 2a,b). No epidermal changes, edema in the papillary dermis, or vasculitis were found. Immunofluorescence staining of frozen tissue sections of a facial nodule showed granular deposits of C3. Inguinal lymph node biopsy revealed, in the paracortical area, focal necrosis with a proliferation of transformed lymphocytes, histiocytes, and numerous nuclear debris typical of histiocytic necrotizing lymphadenitis ( Fig. 3a,b). On immunohistochemical staining examination, CD68 was positive in pathologic paracortical areas. Few mononuclear cells were positive for CD3, CD8, and L‐26 ( Fig. 4). Polymerase chain reaction (PCR) amplification did not show human herpes simplex viruses in the skin biopsy specimen, and culture was also negative. 1 (a) Clinical aspect: erythematous papulonodules on the face. (b) Clinical aspect: erythematous papulonodules of the upper part of the trunk 2 (a) Perivascular and periadnexal dense lympho‐ histiocytic infiltrate involving the dermis (hematoxylin and eosin, × 10). (b) Plasmacytoid histiocytic infiltrate in the subcutaneous fat tissue (hem...

show abstract

Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Kikuchi disease associated with Still disease

et al. 1999

View full text Add to dashboard Cite

show abstract

“… 11 Recently, several cases of human immunodeficiency virus (HIV)‐infected patients with papular mucinosis have been reported; all corresponded to this discrete papular form. 12–16 …”

Section: Discussionmentioning

confidence: 99%

Atypical acral persistent papular mucinosis

Abalde¹,

Ginarte²,

Fernández‐Redondo³

et al. 1999

Int J Dermatology

View full text Add to dashboard Cite

A 70‐year‐old woman presented with a 10‐year history of cutaneous lesions on her calves that worsened with solar exposure. Her past medical history was irrelevant. Physical examination revealed 10–15 erythematous, firm nodules with a diameter of 2–5 mm, which were slightly painful on palpation. The lesions were located on both calves, although some elements extended to the posterior side of the thighs ( Fig. 1). General physical examination did not show any abnormalities. A biopsy specimen from one of the elements showed a normal epidermis and, in the upper dermis, a slight inflammatory infiltrate of mononuclear cells, with the presence of splits between collagen fibers ( Fig. 2). Alcian blue stain at pH 2.5 revealed the existence of mucinous material in these spaces ( Fig. 3). An electron microscopic study did not show any abnormalities. 1 Clinical appearance of the lesions 2 Histopathologic picture (hematoxylin and eosin, ×40) 3 Alcian blue stain showing the presence of mucin in the dermis (Alcian blue, ×100) The patient was diagnosed as having papular mucinosis. The following studies were normal or negative: complete cell blood count, serum biochemistry, serum protein electrophoresis, serum immunoelectrophoresis, serologic test for human immunodeficiency virus (HIV), hepatitis B and C viruses, and syphilis, antinuclear antibodies, and thyroid hormone levels. No treatment was carried out.

show abstract

AIDS and the Skin

Bunker¹,

Gotch²

2004

Rook's Textbook of Dermatology

View full text Add to dashboard Cite

Lichen myxoedematosus associated with human immunodeficiency virus infection - report of two cases and review of the literature

Cited by 11 publications

References 11 publications

Kikuchi disease associated with Still disease

Kikuchi disease associated with Still disease

Atypical acral persistent papular mucinosis

AIDS and the Skin

Contact Info

Product

Resources

About