Lichen planopilaris: Epidemiology and prevalence of subtypes – a retrospective analysis in 104 patients

Meinhard, Johanna; Stroux, Andrea; Lünnemann, Lena; Vogt, Annika; Blume-Peytavi, Ulrike

doi:10.1111/ddg.12264

Cited by 60 publications

(85 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nadir görülen bir hastalık olup, tüm alopesilerin %1,25'ini, sikatrisyel alopesilerin ise %25'ini oluşturur 2,3 . Hastalığın klasik LPP, Graham-Little sendromu ve frontal fibrozan alopesi (FFA) olmak üzere 3 klinik formu vardır 1,4 .…”

Section: Introductionunclassified

“…Hastalığın klasik LPP, Graham-Little sendromu ve frontal fibrozan alopesi (FFA) olmak üzere 3 klinik formu vardır 1,4 . Klasik LPP, skalpte dağınık şekilde ortaya çıkan, perifolliküler eritem ve/veya mor-kahverengi likenoid papüller ile spinöz folliküler hiperkeratozun eşlik ettiği kısmi saç kayıpları ile karakterizedir 1,2,[4][5][6] . Zamanla lezyonlarda skar, atrofi ve depigmentasyon gelişir 5,6 .…”

Section: Introductionunclassified

“…Çoğunlukla kaş dökülmesinin de eşlik ettiği, frontotemporal saç çizgisinde geriye çekilme ve yeni oluşan saç çizgisinde perifolliküler eritem ile folliküler hiperkeratoz tipiktir [8][9][10][11] . LPP'nin patogenezi tam olarak aydınlatılamamıştır 1,2 . Ancak, erektör pili kasının kıl follikülünün fibröz kök kılıfına tutunma noktası olan ve "bulge" adı verilen bölgedeki folliküler epitelyal kök hücrelerin bilinmeyen bir nedene bağlı olarak oluşan otoimmün hasarının rol oynadığı öne sürülmüştür 12 .…”

Section: Introductionunclassified

“…Ancak çalışmamızın geriye dönük olması ve kontrol grubu bulunmaması nedeniyle LPP ile otoimmün hastalıklarla birliktelik veya ilaç kullanımı arasında herhangi bir ilişki olup olmadığını belirlemek mümkün olmadı. Birbirinden farklı klinik tablolara sahip olmalarına rağmen, benzer histopatolojik özellikler göstermeleri nedeniyle FFA, LPP'nin klinik bir varyantı olarak kabul edilmektedir 1,2,4,9,19 . Bununla birlikte yapılan bir çalışmada FFA'da histopatolojik olarak daha fazla apoptoz ve daha az enflamatuvar infiltrasyon izlendiği gözlenmiş ancak bu farkın hastalığın evresiyle ilişkili olabileceği belirtilmiştir 21 .…”

Section: Introductionunclassified

See 3 more Smart Citations

Lichen planopilaris: Demographic, clinical and histopathological characteristics and treatment outcomes of 25 cases

Özcan¹,

Seckın²,

Güleç³

et al. 2015

TURKDERM

View full text Add to dashboard Cite

Background and Design: Lichen planopilaris (LPP) is a type of cicatricial alopecia characterized by autoreactive lymphocytic destruction of the hair follicle. We aimed to evaluate the demographic, clinical and histopathological features, and treatment outcomes of patients with LPP. Materials and Methods: Medical reports of 25 patients, who have been diagnosed with LPP according to the clinical and histopathological findings between January 2006 and June 2012, were retrospectively reviewed. The transverse and vertical sections of scalp biopsy specimens were re-evaluated by a pathologist, and the findings were noted. Results: Of the 25 patients, 18 were female and 7 were male, the mean age was 49.8±12.4 years. Eighteen patients had been diagnosed with classic LPP and 7 patients with frontal fibrosing alopecia (FFA). The alopecia has begun in postmenopausal period in 5 patients with FFA. Alopecia was associated with pruritus, pain and/or burning in 19 patients. Extra-scalp involvement was observed in 11 patients. The most common clinical findings were follicular hyperkeratosis (92%), perifollicular erythema (48%), perifollicular lichenoid papules, and positive hair-pull test (44%). Dermatoscopic examination was performed in 14 patients, and most commonly, absence of follicular openings (100%), perifollicular scales (92.9%) and perifollicular erythema (50%) were noted. The most common diagnostic histopathological findings were follicular vacuolar and lichenoid degeneration (88%) and vacuolar and lichenoid interface changes (56%). Twenty-three patients who were started on treatment received topical, intramuscular and intralesional corticosteroids, topical minoxidil, oral tetracycline, cyclosporine A, and hydroxychloroquine either alone or in combination. Progression of alopecia was prevented and the symptoms and/or signs were reduced in 12 (75%) of 16 patients whose follow-up data were available. Conclusion: LPP can be diagnosed accurately through a detailed clinical examination, dermatoscopy and histopathological examination. The symptoms and/or signs can be reduced and progression of the disease can be prevented with treatment.

show abstract

Section: Introductionunclassified

See 2 more Smart Citations

Lichen planopilaris: Demographic, clinical and histopathological characteristics and treatment outcomes of 25 cases

Özcan¹,

Seckın²,

Güleç³

et al. 2015

TURKDERM

View full text Add to dashboard Cite

show abstract

“…Like LPP, [14] an accelerated association between FFA and disease, exceptionally thyroid, has been illustrious [3,15] but, there square measure variety of areas within which FFA seems to fluctuate from classical LPP. First of all, FFA influences predominantly females: in two tremendous circumstances sequence, male to feminine (M:F) ratio ranged from 1:289 to 1:31, whereas in LPP, M:F has been calculable at between 1:1.8 to 1:49 [16]. Lichen planus moving alternative websites (cutaneous, nail, mucosal) is seen additional usually in association with LPP (28-50%) [17,18] than with FFA (1.6-9.9%) [3,9,15] lack of facial and hair concomitant with LPP is suggested in 7-10% ( Figure 1) [16,18].…”

Section: Introductionmentioning

confidence: 99%

Frontal Fibrosing Alopecia

Holmes¹

2017

Pigmentary Disorders

View full text Add to dashboard Cite

Frontal fibrosing alopecia, described simply over two decades in the past, has come to be probably the most normally noticeable causes of scarring phalacrosis at several skilled hair clinics. Regarded a medical variant of lichen planopilaris (LPP), its uncommon components and associations that distinguish it from LPP. Despite the fact that largely affecting post-menopausal ladies, a small however growing number of guys and premenopausal ladies are affected. The spectrum of the ailment has accelerated from involvement of the frontal hairline and eyebrows, to potentially affecting the whole hairline, facial and body hair. Genetic and environmental motives were implicated however the aetiology remains uncertain. A range of cures had been used in management of the, however medical trials are required to set up effectiveness.

show abstract

Prevalence and Treatment Patterns in Patients With Lichen Planopilaris

Pelet del Toro,

Strunk,

Garg

et al. 2024

JAMA Dermatol

View full text Add to dashboard Cite

ImportanceLichen planopilaris (LPP) is a form of scarring alopecia associated with progressive, permanent hair loss. Symptoms range from burning pain to itching, also carrying substantial psychological morbidity. Yet, disease characteristics, pathophysiology, and effective treatment data are limited, making treatment a challenge.ObjectiveTo describe the prevalence and dermatologist-prescribed treatment patterns of LPP among US adults.Design, Setting, and ParticipantsThis cross-sectional study used the Explorys database. The prevalence analysis used a 15% random sample and identified US adults with LPP diagnoses between 2017 and 2019. The LPP treatment analysis included all patients with LPP diagnoses between 2016 and 2020 and a dermatologist encounter in the first year after diagnosis. Data were analyzed from January 2023 to April 2023.Main Outcomes and MeasuresThe main outcomes of the prevalence analysis were the crude and standardized prevalence estimates of US adults with LPP across age, sex, and racial groups. The main outcomes of the treatment analysis were the frequency of LPP treatments within 1 year of diagnosis, and the number of patients who continued treatment beyond 1 year, switched treatments, and combined treatments.ResultsAmong 1 466 832 eligible patients analyzed for prevalence, 241 patients had an LPP diagnosis (222 [92.1%] female; median [IQR] age, 64 [54-73] years). Standardized overall prevalence was 13.4 per 100 000 (95% CI, 11.7-15.1). In the treatment analysis, 991 patients had an LPP diagnosis (907 [91.5%] female; median (IQR) age, 60 [47-69] years). Most received at least 1 type of medication (635 [64.1%]), most frequently intralesional corticosteroids (370 [37.3%]) and topical corticosteroids (342 [34.5%]), followed by doxycycline (104 [10.5%]) and hydroxychloroquine (72 [7.3%]). Treatment continued beyond 1 year in 71 of 200 patients (35.5%) prescribed intralesional corticosteroids and 7 of 29 patients (24.1%) prescribed hydroxychloroquine. Treatment switching at 1 year occurred in 32 of 254 patients (12.6%) first prescribed an intralesional corticosteroid and in 44 of 194 (22.7%) first prescribed a topical corticosteroid. Combinations of 2 or 3 treatment types were given to 137 (13.8%) and 74 (7.5%) patients, respectively.Conclusions and RelevanceThis cross-sectional study reported prevalence and treatment patterns for US adults with LPP in a representative sample. Most patients with LPP received treatment, and many received multiple treatment types and switched treatments, suggesting further research into medication selection offers clinical benefit.

show abstract

Lichen planopilaris: Epidemiology and prevalence of subtypes – a retrospective analysis in 104 patients

Cited by 60 publications

References 30 publications

Lichen planopilaris: Demographic, clinical and histopathological characteristics and treatment outcomes of 25 cases

Lichen planopilaris: Demographic, clinical and histopathological characteristics and treatment outcomes of 25 cases

Frontal Fibrosing Alopecia

Prevalence and Treatment Patterns in Patients With Lichen Planopilaris

Contact Info

Product

Resources

About