Lichen planus of uterine cervix - the first report of a novel site of occurrence: a case report

Gupta, Ruchika; Bansal, Bhavna; Singh, Sompal; Yadav, Indra; Gupta, Kusum; Kudesia, Madhur

doi:10.1186/1757-1626-2-9306

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…It has been discussed that the chronic inflammation plays a role in the malignant transformation of LP by analogy to ulcerative colitis and colorectal carcinoma [102]. Malignant transformation to squamous cell carcinoma is also described in penile, anal and vulvovaginal LP as well as in esophageal LP [90,91,103,104,105,106,107,108], as it was observed in another case at our hospital that developed an esophageal carcinoma within a chronic LP of the esophagus. With the chronic course of LP, especially in its hypertrophic variant, and an incidence of 9-26% in pediatric LP, it is very important to keep the risk of malignant transformation in mind, particularly in those patients [109,110].…”

Section: Discussionmentioning

confidence: 99%

Oral, Esophageal and Cutaneous Lichen Ruber Planus Controlled with Alitretinoin: Case Report and Review of the Literature

Kolios¹,

Maggio²,

Gubler

et al. 2013

Dermatology

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Background: Therapy-resistant lichen planus (LP) can be a challenging condition for dermatologists. There are some case reports about successful treatments with alitretinoin of cutaneous and oral, but not of esophageal LP. Objective: We present the unique case of a patient with cutaneous, oral and esophageal LP which was refractory to classical treatment options (topical clobetasol propionate and pimecrolimus, intramuscular triamcinolone acetonide); because of systemic side effects the patient did not tolerate systemic acitretin dosed up to 25 mg daily. Methods: Oral alitretinoin was used at a dose of 30 mg daily. Results: Both oral and skin changes as well as dysphagia completely resolved within 4 weeks without any severe side effects and the drug was used for 6 months. No papules, intraoral striae or dysphagia recurred during the 6 months of treatment. After 4 months the patient relapsed with mucosal patches so that a second cycle was initiated for 6 months where oral LP lesions resolved after 4 weeks also (with sporadic mild headache). Conclusion: Further studies are needed to better understand the impact of alitretinoin in LP. Our observation suggests alitretinoin as a new, well-tolerated treatment option for esophageal LP after failed response to conventional treatments.

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Section: Discussionmentioning

confidence: 99%

Oral, Esophageal and Cutaneous Lichen Ruber Planus Controlled with Alitretinoin: Case Report and Review of the Literature

Kolios¹,

Maggio²,

Gubler

et al. 2013

Dermatology

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“…Among the different clinical subtypes of mucosal LP, atrophic-erosive LP is the most frequent in the course of oro-vaginal-vulvar LP (OVVLP). This condition is extremely painful, resulting in irreversible scarring, and if left untreated can rarely progress to squamous cell carcinoma [4]. Currently, there are no evidence-based guidelines on the management of LP.…”

Section: Introductionmentioning

confidence: 99%

Unwarranted hysterectomy in a case of oro-vaginal-vulvar lichen planus in a young woman: a case report

2021

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Background Lichen planus is a rare autoimmune disease primarily affecting the skin and mucous membranes of the oral mucosa, vulva, and vagina. Diagnosis is difficult and often delayed as the clinicians do not associate the oral symptoms with the genital symptoms. This has a negative impact on the out-of-pocket expenditure and quality of life of the patients. We report this case, as only anecdotal cases have been reported so far from a developing country such as India. We highlight the unindicated hysterectomy that the patient had undergone because of lack of awareness regarding this condition. Our case report also highlights the importance of the multidisciplinary team approach to optimize outcomes and avoid unnecessary morbidity to such patients. Case presentation We report a North-Indian patient with oro-vaginal-vulvar lichen planus who presented to us with complaints of recurrent vulvovaginal symptoms for the last 5 years. She had been previously treated with multiple courses of antibiotics, antifungals, and topical steroids over the course of 3 years and finally offered laparoscopic-assisted vaginal hysterectomy (LAVH) by a private practitioner but got no relief. She also had complained of oral symptoms in the form of a burning sensation after eating spicy food, but did not seek any treatment for this. After multidisciplinary team discussion, a final diagnosis of oro-vaginal-vulvar lichen planus was made at our institute based on the clinical and histopathological findings. The patient was immediately started on oral prednisolone to which she responded with improvement in her symptoms. Conclusion Lichen planus is a chronic painful condition with significant impact on the quality of life. Women often suffer for several years before an accurate diagnosis is made. Treatment is challenging and needs to be individualized with a multidisciplinary approach to prevent progressive anatomical distortion and associated morbidity.

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Noninfectious Dermatoses of the Vulva

Luzar

Calonje

2012

Pathology of the Vulva and Vagina

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Lichen planus of uterine cervix - the first report of a novel site of occurrence: a case report

Cited by 6 publications

References 11 publications

Oral, Esophageal and Cutaneous Lichen Ruber Planus Controlled with Alitretinoin: Case Report and Review of the Literature

Oral, Esophageal and Cutaneous Lichen Ruber Planus Controlled with Alitretinoin: Case Report and Review of the Literature

Unwarranted hysterectomy in a case of oro-vaginal-vulvar lichen planus in a young woman: a case report

Noninfectious Dermatoses of the Vulva

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