Lichen sclerosis: clinicopathological study of 60 cases from Lebanon

Knio, Z.; Kurban, Mazen; Abbas, Ossama

doi:10.1111/ijd.13336

Cited by 14 publications

(9 citation statements)

References 24 publications

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“…In a study by Knio et al, perineural inflammation in histopathology was observed in 22/60 cases (33.8%), which is a novel finding in LS that might help in differentiating it from close LS mimics such as lichen planus 47 …”

Section: Histopathologymentioning

confidence: 88%

Extragenital lichen sclerosus: A comprehensive review

Arif¹,

Fatima

Sami³

2022

Aust J Dermatology

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Lichen sclerosus (LS) is a chronic inflammatory mucocutaneous disease of unknown aetiology. About 85% of total cases of LS are genital cases, while extragenital form is seen in only 15-20% of cases. Extragenital LS (EGLS) can occur simultaneously with genital form; however, in 6% of the cases, only extragenital form has been described. Genetic, autoimmune, infectious, environmental and hormonal factors are implicated in its aetiology. Extragenital LS presents as asymptomatic white opalescent papules, which cluster in plaques and slowly progress over time resulting in parchment-like skin usually involving upper trunk, neck and shoulders. Lesions are frequently accompanied by purpura/ haemorrhagic spots. The relationship with morphoea has been a topic of debate.Association with several autoimmune diseases has been observed. Diagnosis is usually based on clinical and dermoscopic examination and further supported by histopathological findings. LS needs to be differentiated from several other dermatological conditions such as discoid lupus erythematosus, vitiligo, mycosis fungoides (hypopigmented variant), lichen planus, graft-versus-host disease and morphoea depending upon the stage of the disease. Generally, extragenital LS is believed to lack carcinogenic potential. However, case reports with possible malignant transformation have been described. In this article, the authors have described a concise review of the extragenital form of LS.

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Section: Histopathologymentioning

confidence: 88%

Extragenital lichen sclerosus: A comprehensive review

Arif¹,

Fatima

Sami³

2022

Aust J Dermatology

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“…In review performed by Fistarol & Itin ( 6 ), the authors reported anogenital LS is clearly more frequent among female patients compared to male patients and shows a remarkable predilection for prepubertal girls and post-menopausal women. Recently, Knio et al ( 20 ) demonstrated in clinicopathologic study that among 60 patients with LS (genital and extragenital) 70% were women. Attili and Attili ( 21 ) did not found predilection for any gender in a clinicopathologic study of lips LS, however, we observed that oral LS demonstrated a slight predilection for the female gender ( Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

“…In general, histopathologic characteristics of oral LS are not highly different from the characteristics of skin and anogenital LS. Knio et al ( 20 ) indicated genital LS lesions were more likely to present epithelial hyperplasia, while extragenital lesions were mostly associated to epithelial atrophy. However, the main histologic feature of LS is the band of hyalinized collagen fibers immediately below the epithelium, which might show variable density, organization and thickness.…”

Section: Discussionmentioning

confidence: 99%

Uncommon oral manifestation of lichen sclerosus: critical analysis of cases reported from 1957 to 2016

Tomo¹,

Santos²,

Queiroz³

et al. 2017

Med Oral

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BackgroundLichen sclerosus is a mucocutaneous autoimmune disease which might be initiated by infectious pathogens as Borrelia Bugrdorferi and HPV. This disease shows destructive potential and is rarely diagnosed in oral mucosa. The purpose of this paper is to evaluate the characteristics of cases described in literature from 1957 to 2016, looking to provide valuable evidence about clinicopathologic features of this disease.Material and MethodsA MedLine search was performed aiming to find oral lichen sclerosus cases in literature and discuss its demographical and pathological characteristics as well as treatment methods performed for these cases.Results34 oral lichen sclerosus cases with histological confirmation and one clinicopathologic study linked with this disease were found in literature. Oral lichen sclerosus affected most commonly female patients, were asymptomatic and not associated to skin or genital lesions. Furthermore, affected patients in a range of 7 – 70-years old (Average age = 31.81).ConclusionsOral lichen sclerosus is a rare pathologic process with slight predilection for prepubertal girls, for which topical corticosterois have demonstrated satisfactory therapeutic value. Key words:Lichen sclerosus et atrophicous, skin diseases, mouth disease, autoimmune diseases, mouth.

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“…Also, other studies examined autoantibodies in a number of patients with LS; however, anti-SS-A antibody was not detected [2,3]. In a recent report Extra-genital lichen sclerosus in a patient with Extra-genital lichen sclerosus in a patient with anti-SS-A antibody anti-SS-A antibody from Lebanon, nine out of 60 LS patients (15%) had at least one associated autoimmune disease, among which five cases of localized scleroderma, three cases of autoimmune thyroid disease, and one case of SLE were observed [5], but none had SjS. In conclusion, to our knowledge, there have been no reports on associated cases of LS and SjS; however, our patient is under follow-up to examine whether SjS will develop in the future.…”

Section: Sirmentioning

confidence: 99%