A 37-year-old woman, with non-relevant medical history, presented with fever, asthenia, dysgeusia, anosmia, burning tongue sensation, and dry mouth for 3 days. PCR test of nasopharyngeal swab was positive to SARS-CoV-2, confirming the diagnosis of COVID-19.She was sent to social isolation at home and medicated with dexamethasone and dipyrone. On the 9th day, the patient searched for dental tele-assistance due to the worsening of burning sensation in the borders of the tongue and soft palate. We asked her to send us photographs of these locations (Figure 1), in which it is possible to observe a diffuse erythema and discrete depapillation with red spots in the borders of tongue, but no lesion on the palate. In front of this mucositis condition, we oriented the patient regarding hydration and prescribed chlorhexidine 0.12% mouthwashes 3×/day. Two weeks after the first COVID-19 symptoms onset, the patient is asymptomatic.

Hereditary palmoplantar keratoderma (PPK) is a heterogeneous group of disorders characterized by hyperkeratosis of the palm and the sole skin. Hereditary PPK are divided into four groups -diffuse, focal, striate and punctate PPK -according to the clinical patterns of the hyperkeratotic lesions. Each group includes simple PPK, without associated features, and PPK with associated features, such as involvement of nails, teeth and other organs. PPK have been classified by a clinically based descriptive system. In recent years, many causative genes of PPK have been identified, which has confirmed and/or rearranged the traditional classifications. It is now important to diagnose PPK by a combination of the traditional morphological classification and genetic testing. In this review, we focus on PPK without associated features and introduce their morphological features, genetic backgrounds and new findings from the last decade.

Ehlers-Danlos syndrome (EDS) is a clinically and genetically heterogeneous disorder. Using a customized targeted exome-sequencing system we identified nonsense mutations in TNXB in a patient who had recurrent gastrointestinal perforation due to tissue fragility. This case highlights the utility of targeted exome sequencing for the diagnosis of congenital diseases showing genetic heterogeneity, and the importance of attention to gastrointestinal perforation in patients with tenascin-X deficient type EDS.

This study indicates fluorescence visualization is capable of improve inexperienced professionals' efficacy for early detecting oral lesions more prone to be dysplastic and oral potentially malignant disorders.