Lichenoid contact reaction to eugenol presenting as oral lichen planus

Behzad, Melika; Michl, Christiane; Arweiler, Nicole Birgit; Pfützner, Wolfgang

doi:10.1007/s40629-014-0027-z

Cited by 9 publications

(8 citation statements)

References 25 publications

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“…In light of TRPA1 upregulation in OLP, it may eventually become important that TRPA1 is known to mediate contact hypersensitivity (Tóth et al , ). Furthermore, its agonists (cinnamaldehyde, menthol, eugenol as food flavorings) can cause lichen planus‐like lesions (lichenoid reaction) in the oral mucosa (Schlosser, ; Behzad et al , ).…”

Section: Discussionmentioning

confidence: 99%

“…Although no direct link has been established, literature data could eventually suggest a possible implication of TRPA1 in OLP: (i) plant‐derived TRPA1 agonists such as cinnemaldehyde can cause lichenoid (OLP‐like) lesions (Schlosser, ; Behzad et al , ); (ii) avoiding spicy foods and mint or cinnamon flavored oral hygiene products can alleviate OLP (Schlosser, ; Olson et al , ); and (iii) anti‐inflammatory and nociceptive curcuminoids used in OLP therapy may rapidly desensitize TRPA1 (Leamy et al , ; Ming‐Tatt et al , ; Olson et al , ).…”

Section: Introductionmentioning

confidence: 99%

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TRPA1 receptor is upregulated in human oral lichen planus

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

TRPA1 receptor is upregulated in human oral lichen planus

et al. 2016

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“…The patient had no positive reaction to any of the tested substances at either 48 or 72 h after testing. Since it is often used in combination with zinc oxide in dentistry, eugenol as a single substance was tested and the reaction was positive to eugenol after 72 h, a fact that revealed that eugenol caused delayed-type sensitization [96].…”

Section: Eugenolmentioning

confidence: 99%

Essential Oils and Their Single Compounds in Cosmetics—A Critical Review

2018

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Essential oils are widely incorporated in cosmetic products, perfumes and related household products due to the variety of their properties but mainly due to their pleasant odour. The composition of these volatile natural complex mixtures may vary depending on the quality of plant material from which they were obtained and the extraction method by which they were derived. These factors are also important in ensuring the safe use of essential oils in personal care products. As they contain compounds with varied chemical structure and effects, skin sensitivity and irritations as well as other symptoms may arise after their application. Although essential oils are considered as safe and nontoxic when used at low concentrations, available scientific literature indicates that essential oils and their compounds may possess a strong allergy potential. This review focuses on side effects and allergy contact dermatitis caused by selected essential oils and their single compounds in cosmetic products, summarizing data from the most recent scientific literature.

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“…Burning sensations orally and contact allergy to eugenol are well known. [6][7][8] In the present case, the bulk of eugenol exposure was from eating cinnamon every morning and chewing cloves during the day, as the mouthwash was not used on a daily basis. The patient was told to avoid all identified exposures.…”

Section: Discussionmentioning

confidence: 91%

“…In this case, eugenol was found in the patient's mouthwash and, quite surprisingly, also constituted a daily part of her diet. Burning sensations orally and contact allergy to eugenol are well known . In the present case, the bulk of eugenol exposure was from eating cinnamon every morning and chewing cloves during the day, as the mouthwash was not used on a daily basis.…”

Section: Discussionmentioning

confidence: 99%